Gfap Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gfap
glial fibrillary acidic protein
MGI:95697

25 phenotypes from 10 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gfap^tm1Ito/Gfap^tm1Ito involves: 129P2/OlaHsd * C57BL/6J	abnormal excitatory postsynaptic potential	J:32098
	abnormal eye blink conditioning behavior	J:32098
	normal behavior/neurological phenotype	J:32098
	normal nervous system phenotype	J:32098
	reduced long-term depression	J:32098
Gfap^tm1Ldtk/Gfap^tm1Ldtk involves: 129P2/OlaHsd * C57BL/6	abnormal astrocyte morphology	J:77630
	abnormal blood vessel morphology	J:77630
	abnormal blood-brain barrier function	J:77630
	abnormal brain white matter morphology	J:77630
	abnormal myelination	J:77630
	abnormal oligodendrocyte morphology	J:77630
	abnormal oligodendrocyte physiology	J:77630
	decreased corpus callosum size	J:77630
	non-obstructive hydrocephaly	J:77630
Gfap^tm1Mes/Gfap^tm1Mes either: (involves: 129S7/SvEvBrd * 129X1/SvJ) or (involves: 129S7/SvEvBrd * C57BL/6)	abnormal astrocyte morphology	J:64290
	enhanced long-term potentiation	J:64290
	increased susceptibility to injury	J:48767
Gfap^tm1Pkny/Gfap^tm1Pkny involves: 129P2/OlaHsd * C57BL/6J	abnormal astrocyte morphology	J:25093, J:125659
	normal behavior/neurological phenotype	J:25093
	normal cellular phenotype	J:125659
	normal digestive/alimentary phenotype	J:25093
	normal nervous system phenotype	J:25093, J:125659
Gfap^tm2Ito/Gfap^tm2Ito either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	normal nervous system phenotype	J:78341
Gfap^tm2Mes/Gfap⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N	abnormal astrocyte morphology	J:114689
	abnormal brain iron level	J:114689
	decreased body size	J:114689
	gliosis	J:114689
	increased susceptibility to pharmacologically induced seizures	J:114689
Gfap^tm2Mes/Gfap^tm2Mes involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N	abnormal astrocyte morphology	J:114689
	decreased body weight	J:114689
	gliosis	J:114689
Gfap^tm3Ito/Gfap^tm3Ito either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal astrocyte morphology	J:78341
Gfap^tm3Mes/Gfap⁺ involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N	abnormal astrocyte morphology	J:114689
	decreased body size	J:114689
	gliosis	J:114689
Gfap^tm3Mes/Gfap^tm3Mes involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N	abnormal astrocyte morphology	J:114689
	decreased body weight	J:114689
	gliosis	J:114689
Gfap^tm4Ito/Gfap^tm4Ito either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal astrocyte morphology	J:78341
	abnormal CNS glial cell morphology	J:78341
Gfap^tm5Ito/Gfap^tm5Ito involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:99896

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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