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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gja1
gap junction protein, alpha 1
MGI:95713
232 phenotypes from 21 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gja1Gt(ROSANBetageo)15C3Masn/Gja1Gt(ROSANBetageo)15C3Masn
involves: 129P2/OlaHsd
abnormal heart development J:123502
perinatal lethality, complete penetrance J:123502
Gja1M1Jrt/Gja1+
involves: C3H/HeJ * C57BL/6J
abnormal bone marrow cell morphology/development J:101733
abnormal cardiac muscle contractility J:101733
abnormal cranium morphology J:101733
abnormal digit morphology J:101733
abnormal granulosa cell morphology J:146211
abnormal impulse conducting system conduction J:101733
abnormal incisor morphology J:101733
abnormal iris morphology J:101733
abnormal lactation J:146211
abnormal myocardium layer morphology J:101733
abnormal ovary morphology J:146211
abnormal phalanx morphology J:101733
abnormal proerythroblast morphology J:101733
abnormal tooth morphology J:101733
normal behavior/neurological phenotype J:101733
brittle teeth J:101733
cardiac fibrosis J:101733
cornea opacity J:101733
decreased body size J:101733
decreased bone marrow cell number J:101733
decreased granulosa cell proliferation J:146211
decreased heart left ventricle muscle contractility J:101733
decreased heart right ventricle muscle contractility J:101733
decreased litter size J:146211
decreased mature ovarian follicle number J:146211
decreased superovulation rate J:146211
normal hearing/vestibular/ear phenotype J:101733
heart inflammation J:101733
increased granulosa cell apoptosis J:146211
irregularly shaped pupil J:101733
patent cardiac foramen ovale J:101733
premature death J:101733
prolonged PR interval J:101733
prolonged QRS complex duration J:101733
reduced enamel thickness J:101733
reduced female fertility J:146211
syndactyly J:101733
ventricular premature beat J:101733
Gja1M1Jrt/Gja1+
involves: C3H/HeJ * C57BL/6J * FVB/N
abnormal craniofacial bone morphology J:101733
abnormal impulse conducting system conduction J:101733
abnormal ovary morphology J:101733
decreased body size J:101733
decreased bone mineral content J:101733
decreased bone mineral density J:101733
decreased bone strength J:101733
decreased heart rate J:101733
delayed bone ossification J:101733
irregular heartbeat J:101733
prolonged P wave J:101733
prolonged PR interval J:101733
prolonged QRS complex duration J:101733
Gja1tm1.1Gfi/Gja1+
Not Specified
abnormal coronary artery morphology J:108525
Gja1tm1.1Gfi/Gja1tm1.1Gfi
Not Specified
abnormal cardiac outflow tract development J:108525
abnormal heart right ventricle outflow tract morphology J:108525
abnormal nervous system development J:108525
abnormal trabecula carnea morphology J:108525
decreased heart right ventricle wall thickness J:108525
perinatal lethality J:108525
Gja1tm1.1Kwi/Gja1+
involves: 129P2/OlaHsd
abnormal neutrophil physiology J:129091
Gja1tm1.1Kwi/Gja1tm1.1Kwi
involves: 129P2/OlaHsd
neonatal lethality, complete penetrance J:78662
Gja1tm1.1Kwi/Gja1tm4Kwi
involves: 129P2/OlaHsd * C57BL/6
normal integument phenotype J:95050
postnatal lethality, incomplete penetrance J:95050
Gja1tm1Clo/Gja1+
Not Specified
no abnormal phenotype detected J:253159
Gja1tm1Clo/Gja1tm1Clo
Not Specified
no abnormal phenotype detected J:253159
Gja1tm1Dlg/Gja1tm1Dlg
involves: 129S7/SvEvBrd * C57BL/6
no abnormal phenotype detected J:71092
Gja1tm1Dlg/Gja1tm1Dlg
Tg(GFAP-cre)1Kdmc/0
involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6J
abnormal behavior J:156098
abnormal brain morphology J:156098
abnormal cerebellar cortex morphology J:156098
abnormal cerebellar granule layer morphology J:156098
abnormal cerebellar lobule formation J:156098
abnormal cerebellar Purkinje cell layer J:156098
abnormal cerebellum external granule cell layer morphology J:156098
abnormal cerebellum morphology J:156098
abnormal cortical ventricular zone morphology J:156098
abnormal dentate gyrus morphology J:156098
abnormal gait J:156098
abnormal hippocampus morphology J:156098
abnormal motor capabilities/coordination/movement J:156098
abnormal postnatal subventricular zone morphology J:156098
abnormal radial glial cell morphology J:156098
ataxia J:156098
decreased body size J:156098
delaminated cerebellar granule layer J:156098
delaminated Purkinje cell layer J:156098
ectopic cerebellar granule cells J:156098
enlarged brain ventricles J:156098
enlarged lateral ventricles J:156098
poor grooming J:156098
premature death J:156098
small cerebellum J:156098
small hippocampus J:156098
thin external granule cell layer J:156098
Gja1tm1Dlg/Gja1tm1Dlg
Tg(Tek-cre)1Ywa/0
involves: 129S7/SvEvBrd * C57BL/6
abnormal blood homeostasis J:71092
abnormal cardiovascular system physiology J:71092
abnormal circulating hormone level J:71092
decreased heart rate J:71092
decreased systemic arterial systolic blood pressure J:71092
hypotension J:71092
Gja1tm1Gfi/Gja1tm1.1Gfi
Tg(Pax3-cre)1Joe/0
involves: 129/Sv * C57BL/6 * FVB/N * SJL
abnormal coronary artery morphology J:108525
abnormal heart development J:108525
abnormal heart right ventricle outflow tract morphology J:108525
abnormal nervous system development J:108525
abnormal trabecula carnea morphology J:108525
decreased birth body size J:108525
decreased birth weight J:108525
decreased heart right ventricle wall thickness J:108525
postnatal lethality, incomplete penetrance J:108525
Gja1tm1Gfi/Gja1tm1Gfi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6J * CBA/J * FVB/N
abnormal ascending aorta and coronary artery attachment J:108525
Gja1tm1Gfi/Gja1tm1Gfi
Myl2tm1(cre)Krc/Myl2+
Not Specified
premature death J:91971
Gja1tm1Gfi/Gja1tm1Gfi
Tg(Myh6-cre)2182Mds/0
Not Specified
increased heart rate J:91971
premature death J:91971
Gja1tm1Kdr/Gja1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal coronary artery morphology J:112454
abnormal impulse conducting system conduction J:39599
prolonged QRS complex duration J:39599
Gja1tm1Kdr/Gja1tm1.1Kwi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
neonatal lethality, complete penetrance J:78662
Gja1tm1Kdr/Gja1tm1Kdr
involves: 129S1/Sv * 129X1/SvJ
abnormal breathing pattern J:24121
abnormal cardiac outflow tract development J:24121
abnormal heart right ventricle outflow tract morphology J:24121
abnormal pulmonary gas exchange J:24121
abnormal pulmonary valve morphology J:24121
abnormal trabecula carnea morphology J:24121
abnormal vascular smooth muscle physiology J:212895
cyanosis J:24121
edema J:24121
neonatal lethality, complete penetrance J:24121
Gja1tm1Kdr/Gja1tm1Kdr
involves: 129S1/Sv * 129X1/SvJ * C57BL
abnormal alisphenoid bone morphology J:65866
abnormal cranium morphology J:65866
abnormal neurocranium morphology J:65866
abnormal occipital bone morphology J:65866
abnormal osteoblast differentiation J:65866
abnormal osteoblast physiology J:65866
abnormal parietal bone morphology J:65866
abnormal rib morphology J:65866
abnormal thoracic cage morphology J:65866
abnormal tooth development J:65866
abnormal zygomatic arch morphology J:65866
decreased tympanic ring size J:65866
delayed bone ossification J:65866
delayed endochondral bone ossification J:65866
delayed intramembranous bone ossification J:65866
interparietal bone hypoplasia J:65866
pointed snout J:65866
short zygomatic bone J:65866
small cranium J:65866
small frontal bone J:65866
small lower incisors J:65866
small mandible J:65866
small maxilla J:65866
small nasal bone J:65866
small neurocranium J:65866
small snout J:65866
thin parietal bone J:65866
Gja1tm1Kdr/Gja1tm1Kdr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal cardiovascular system physiology J:39599
abnormal suckling behavior J:39599
Gja1tm1Kdr/Gja1tm1Kdr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
decreased germ cell number J:54458
impaired ovarian folliculogenesis J:54458
small ovary J:54458
small testis J:54458
Gja1tm1Kdr/Gja1tm1Kdr
involves: 129S1/Sv * 129X1/SvJ * CD-1
decreased male germ cell number J:71071
Gja1tm1Kdr/Gja1tm1Kdr
Tg(CMV-Gja1)BClo/0
involves: 129S1/Sv * 129X1/SvJ * SJL/J * SWR/J
abnormal blood circulation J:40388
abnormal heart morphology J:40388
heart right ventricle hypertrophy J:40388
postnatal lethality J:40388
Gja1tm1Kdr/Gja1tm1Kwi
Tg(Tek-cre)5326Sato/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
no abnormal phenotype detected J:78662
Gja1tm1Kwi/Gja1+
Tg(KRT5-cre)5132Jlj/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
abnormal lymphatic vessel morphology J:188626
absent lymphatic vessels J:188626
lethality throughout fetal growth and development, complete penetrance J:188626
lymphedema J:188626
Gja1tm1Kwi/Gja1tm1Kwi
involves: 129P2/OlaHsd
normal cardiovascular system phenotype J:102342
Gja1tm1Kwi/Gja1tm1Kwi
involves: 129P2/OlaHsd * C57BL/6 * CBA
abnormal muscle regeneration J:94694
Gja1tm1Kwi/Gja1tm1Kwi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * C57BL/6 * CBA
no abnormal phenotype detected J:110142
Gja1tm1Kwi/Gja1tm1Kwi
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal Sertoli cell morphology J:122838
abnormal spermatid morphology J:122838
abnormal spermatogonia morphology J:122838
arrest of spermatogenesis J:122838
azoospermia J:122838
decreased male germ cell number J:122838
decreased testis weight J:122838
increased Leydig cell number J:122838
increased Sertoli cell number J:122838
male infertility J:122838
normal reproductive system phenotype J:122838
small seminiferous tubules J:122838
small testis J:122838
Gja1tm1Kwi/Gja1tm1Kwi
Tg(S100b-cre)20Ito/0
involves: 129P2/OlaHsd * C57BL/6
abnormal glial cell physiology J:159160
normal behavior/neurological phenotype J:159160
normal nervous system phenotype J:159160
Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
involves: 129P2/OlaHsd
abnormal impulse conducting system conduction J:102342
abnormal neutrophil physiology J:129091
increased heart rate J:102342
irregular heartbeat J:102342
Gja1tm1Kwi/Gja1tm5(cre/ERT)Kwi
involves: 129P2/OlaHsd * C57BL/6
impaired skin barrier function J:85065
Gja1tm2Clo/Gja1+
Not Specified
no abnormal phenotype detected J:253159
Gja1tm2Clo/Gja1tm2Clo
Not Specified
no abnormal phenotype detected J:253159
Gja1tm3.1Clo/Gja1tm3.1Clo
B6.Cg-Gja1tm1.1Clo
abnormal vascular smooth muscle cell proliferation J:212895
abnormal vascular wound healing J:212895
Gja1tm3Gfi/Gja1+
involves: 129S1/Sv * 129X1/SvJ * CD-1
abnormal heart electrocardiography waveform feature J:130575
abnormal impulse conducting system conduction J:130575
abnormal myocardial fiber physiology J:130575
normal cardiovascular system phenotype J:130575
decreased QRS amplitude J:130575
preweaning lethality, incomplete penetrance J:130575
syndactyly J:130575
ventricular tachycardia J:130575
Gja1tm3Gfi/Gja1tm3Gfi
involves: 129S1/Sv * 129X1/SvJ * CD-1
preweaning lethality, complete penetrance J:130575
Gja1tm4Kwi/Gja1tm4Kwi
involves: 129P2/OlaHsd * C57BL/6
abnormal epidermis stratum corneum morphology J:95050
abnormal epidermis stratum granulosum morphology J:95050
abnormal heart shape J:95050
abnormal ovarian follicle morphology J:95050
abnormal skin condition J:95050
absent corpus luteum J:95050
absent mature ovarian follicles J:95050
decreased heart rate J:95050
dilated heart left ventricle J:95050
female infertility J:95050
impaired luteinization J:95050
impaired skin barrier function J:95050
postnatal lethality, incomplete penetrance J:95050
prolonged QT interval J:95050
small heart J:95050
Gja1tm6(Gjb3)Kwi/Gja1tm6(Gjb3)Kwi
involves: 129P2/OlaHsd * C57BL/6
no abnormal phenotype detected J:106509
Gja1tm7(Gja2)Kwi/Gja1+
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal mammary gland growth during pregnancy J:126511
decreased heart rate J:126511
Gja1tm7(Gja2)Kwi/Gja1tm7(Gja2)Kwi
involves: 129P2/OlaHsd * C57BL/6 * SJL
abnormal atrioventricular bundle conduction J:126511
abnormal cardiovascular system physiology J:126511
abnormal ovarian follicle number J:126511
abnormal spermatocyte morphology J:126511
abnormal spermatogenesis J:126511
absent corpus luteum J:126511
azoospermia J:126511
decreased body weight J:126511
decreased heart rate J:126511
decreased testis weight J:126511
female infertility J:126511
impaired ovarian folliculogenesis J:126511
male infertility J:126511
ovary cyst J:126511
postnatal growth retardation J:126511
postnatal lethality, incomplete penetrance J:126511
prenatal lethality, incomplete penetrance J:126511
prolonged QRS complex duration J:126511
shortened QT interval J:126511
small heart J:126511
small ovary J:126511
Gja1tm8.1Kwi/Gja1+
involves: 129S2/SvPas * BALB/c * C57BL/6
lethality throughout fetal growth and development, incomplete penetrance J:132032
Gja1tm8Kwi/Gja1+
Tg(Nes-cre)1Kln/0
involves: 129S2/SvPas * C57BL/6 * SJL
normal mortality/aging J:132032
Gja1tm8Kwi/Gja1+
Tg(Pgk1-cre)1Lni/0
involves: 129S2/SvPas * BALB/c * C57BL/6
abnormal cell physiology J:132032
abnormal craniofacial morphology J:132032
abnormal nasal bone morphology J:132032
abnormal skeleton morphology J:132032
abnormal tooth hard tissue morphology J:132032
abnormal trabecular bone morphology J:132032
abnormal zygomatic arch morphology J:132032
decreased bone mineral density J:132032
decreased trabecular bone mass J:132032
depressed nasal bridge J:132032
lethality throughout fetal growth and development, incomplete penetrance J:132032
microcephaly J:132032
reduced enamel thickness J:132032
small face J:132032
small mandible J:132032
sparse hair J:132032
syndactyly J:132032
Gja1tm8Kwi/Gja1+
Tg(Myh6-cre)2182Mds/0
involves: 129S2/SvPas * FVB/N
abnormal heart electrocardiography waveform feature J:132032
abnormal myocardial fiber physiology J:132032
abnormal R wave J:132032
normal cardiovascular system phenotype J:132032
irregular heartbeat J:132032
lethality throughout fetal growth and development, incomplete penetrance J:132032
premature death J:132032
prolonged QRS complex duration J:132032
ventricular tachycardia J:132032
Gja1tm10Kwi/Gja1tm10Kwi
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
abnormal cardiac outflow tract development J:194957
abnormal myocardial trabeculae morphology J:194957
normal cardiovascular system phenotype J:194957
neonatal lethality, complete penetrance J:194957
prolonged QRS complex duration J:194957
Gja1tm10Kwi/Gja1tm10Kwi
Tg(Myh6-icre/ERT2)#Wet/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
abnormal myocardial fiber physiology J:194957
atrioventricular block J:194957
normal cardiovascular system phenotype J:194957
irregular heartbeat J:194957
premature death J:194957
prolonged QRS complex duration J:194957
ventricular fibrillation J:194957
ventricular tachycardia J:194957
Gja1W45X/Gja1W45X
C57BL/6J-Gja1W45X
abnormal coronary artery morphology J:94456
abnormal coronary vein morphology J:94456
abnormal coronary vessel morphology J:94456
abnormal heart morphology J:94456
abnormal interventricular septum morphology J:94456
coronary artery aneurysm J:94456
coronary fistula J:94456
semilunar valve regurgitation J:94456
thick aortic valve J:94456
thick pulmonary valve J:94456
thick semilunar valve J:94456
thin myocardium compact layer J:94456
thin right ventricle myocardium compact layer J:94456
Tg(CMV-Gja1)BClo/0
involves: CD-1 * SJL/J * SWR/J
abnormal cell physiology J:40388
abnormal neural tube morphology J:40388
postnatal lethality J:40388
Tg(CMV-Gja1)BClo/0
involves: SJL/J * SWR/J
abnormal heart morphology J:40388
abnormal neural tube morphology J:40388
abnormal somatic nervous system morphology J:40388
delayed neural tube closure J:40388
pregnancy-related premature death J:40388
premature death J:40388
Tg(CMV-Gja1)BClo/Tg(CMV-Gja1)BClo
involves: SJL/J * SWR/J
abnormal coronary vessel morphology J:40388
abnormal facial nerve morphology J:40388
abnormal heart right ventricle outflow tract morphology J:40388
abnormal heart shape J:40388
abnormal heart ventricle morphology J:40388
abnormal hypoglossal nerve morphology J:40388
abnormal interventricular septum morphology J:40388
abnormal myocardial trabeculae morphology J:40388
abnormal myocardium layer morphology J:40388
abnormal neural plate morphology J:40388
abnormal neural tube morphology J:40388
abnormal oculomotor nerve morphology J:40388
abnormal somatic nervous system morphology J:40388
abnormal spinal nerve morphology J:40388
absent trochlear nerve J:40388
collapsed brain ventricles J:40388
decreased body size J:40388
delayed neural tube closure J:40388
dilated heart right ventricle J:40388
dilated vasculature J:40388
exencephaly J:40388
heart right ventricle outflow tract stenosis J:40388
incomplete rostral neuropore closure J:40388
postnatal lethality J:40388
pregnancy-related premature death J:40388
premature death J:40388
small trigeminal ganglion J:40388
thin right ventricle myocardium compact layer J:40388
ventricular aneurysm J:40388

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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory