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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gli2
GLI-Kruppel family member GLI2
MGI:95728
93 phenotypes from 7 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
En1tm2(cre)Gld/En1+
Gli2tm1Alj/Gli2tm6Alj
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar granule layer morphology J:108507
abnormal cerebellar lobule formation J:108507
abnormal cerebellar molecular layer J:108507
abnormal cerebellar Purkinje cell layer J:108507
abnormal cerebellum anterior vermis morphology J:108507
abnormal cerebellum external granule cell layer morphology J:108507
abnormal cerebellum vermis morphology J:108507
abnormal gait J:108507
decreased body size J:108507
impaired balance J:108507
normal nervous system phenotype J:108507
small cerebellum J:108507
thin external granule cell layer J:108507
tremors J:108507
Gli2tm1Alj/Gli2+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal neural tube morphology J:152259
Gli2tm1Alj/Gli2tm1Alj
either: (involves: 129S1/Sv * 129X1/Sv) or (involves: 129S1/Sv * 129X1/Sv * CD-1) 		abnormal basioccipital bone morphology J:38381
abnormal basisphenoid bone morphology J:38381
abnormal frontal bone morphology J:38381
abnormal head shape J:38381
abnormal long bone morphology J:38381
abnormal palatal shelf elevation J:38381
abnormal palatal shelf fusion at midline J:38381
abnormal parietal bone morphology J:38381
abnormal spine curvature J:38381
abnormal vertebral body morphology J:38381
absent intervertebral disk J:38381
absent lower incisors J:38381
absent maxillary shelf J:38381
absent palatine bone horizontal plate J:38381
absent presphenoid bone J:38381
absent tympanic ring J:38381
absent upper incisors J:38381
bowed radius J:38381
cleft secondary palate J:38381
decreased embryo size J:38381
delayed bone ossification J:38381
edema J:38381
increased rib number J:38381
microcephaly J:38381
perinatal lethality, complete penetrance J:38381
short femur J:38381
short fibula J:38381
short humerus J:38381
short limbs J:38381
short maxilla J:38381
short radius J:38381
short sternum J:38381
short tibia J:38381
short ulna J:38381
small mandible J:38381
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ 		abnormal neuron differentiation J:112802
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * FVB/N 		abnormal epiphyseal plate morphology J:153743
absent temporomandibular joint disk J:153743
decreased chondrocyte number J:153743
small mandibular condyloid process J:153743
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal esophageal smooth muscle morphology J:49603
abnormal esophagus development J:49603
abnormal foregut morphology J:49603
abnormal lung development J:49603
abnormal neural tube morphology J:152259
abnormal right lung morphology J:49603
abnormal tracheal cartilage morphology J:49603
decreased lung weight J:49603
decreased mesenchymal cell proliferation involved in lung development J:49603
esophagus hypoplasia J:49603
esophagus stenosis J:49603
increased type II pneumocyte number J:49603
pulmonary hypoplasia J:49603
small lung J:49603
small lung saccule J:49603
thick lung-associated mesenchyme J:49603
trachea hypoplasia J:49603
trachea stenosis J:49603
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:94461
perinatal lethality, complete penetrance J:94461
reduced cerebellar foliation J:94461
small cerebellum J:94461
thin external granule cell layer J:94461
Gli2tm1Alj/Gli2tm2.1Alj
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal notochord morphology J:73074
abnormal spinal cord morphology J:73074
abnormal ventral interneuron 3 morphology J:73074
absent floor plate J:73074
absent right lung accessory lobe J:73074
persistence of notochord tissue J:73074
small lung J:73074
Gli2tm1Alj/Gli2tm6.1Alj
involves: 129/Sv * C57BL/6 * SJL 		abnormal cerebellar foliation J:108507
abnormal developmental patterning J:108507
abnormal rostral-caudal axis patterning J:108507
hydrocephaly J:108507
perinatal lethality, complete penetrance J:108507
reduced cerebellar foliation J:108507
small cerebellum J:108507
thin external granule cell layer J:108507
Gli2tm1Alj/Gli2tm6Alj
Tg(Nes-cre)1Kln/0
involves: 129/Sv * C57BL/6 * SJL * Swiss Webster 		abnormal cerebellar foliation J:108507
Gli2tm2.1(Gli3)Blnw/Gli2tm2.1(Gli3)Blnw
involves: 129S6/SvEvTac * C57BL/6 		decreased body size J:169530
Gli2tm2.1Alj/Gli2tm2.1Alj
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		abnormal notochord morphology J:73074
abnormal spinal cord morphology J:73074
abnormal ventral interneuron 3 morphology J:73074
absent floor plate J:73074
absent right lung accessory lobe J:73074
persistence of notochord tissue J:73074
small lung J:73074
Gli2tm2.1Alj/Gli2tm2.1Alj
involves: 129S6/SvEvTac * Black Swiss * Swiss Webster 		perinatal lethality J:112460
normal reproductive system phenotype J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj
involves: 129S6/SvEvTac * C57BL/6 * Swiss Webster 		abnormal floor plate morphology J:169530
abnormal motor neuron morphology J:169530
Gli2tm6.1Alj/Gli2tm6.1Alj
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * SJL 		abnormal cerebellar foliation J:108507
abnormal developmental patterning J:108507
abnormal rostral-caudal axis patterning J:108507
hydrocephaly J:108507
perinatal lethality, complete penetrance J:108507
reduced cerebellar foliation J:108507
small cerebellum J:108507
thin external granule cell layer J:108507
Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+
involves: 129S7/SvEvBrd 		normal digestive/alimentary phenotype J:199664
Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+
Tg(Col2a1-cre)3Amc/0
involves: 129X1/SvJ 		abnormal cartilage development J:154905
abnormal long bone epiphyseal plate proliferative zone J:154905
decreased body size J:154905
decreased length of long bones J:154905
decreased width of hypertrophic chondrocyte zone J:154905
increased width of hypertrophic chondrocyte zone J:154905
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory