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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gli2
GLI-Kruppel family member GLI2
MGI:95728
117 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ankmy2tm1b(EUCOMM)Hmgu/Ankmy2tm1b(EUCOMM)Hmgu
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N 		abnormal embryonic neuroepithelial layer differentiation J:297055
embryonic lethality prior to organogenesis J:297055
exencephaly J:297055
incomplete rostral neuropore closure J:297055
Cdk20tm1.1Jegg/Cdk20tm1.1Jegg
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N 		abnormal dorsal-ventral axis patterning J:243907
abnormal neural tube morphology J:243907
En1tm2(cre)Gld/En1+
Gli1tm2Alj/Gli1tm2Alj
Gli2tm1Alj/Gli2tm6Alj
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:108507
abnormal cerebellum development J:108507
abnormal cerebellum morphology J:108507
Gli1tm1Alj/Gli1+
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal lung morphology J:60986
small lung J:60986
Gli1tm1Alj/Gli1tm1Alj
Gli2tm1Alj/Gli2+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal digestive system morphology J:60986
abnormal external male genitalia morphology J:60986
abnormal floor plate morphology J:60986
abnormal gait J:60986
abnormal left lung morphology J:60986
abnormal lung morphology J:60986
abnormal motor neuron morphology J:60986
abnormal notochord morphology J:60986
abnormal right lung accessory lobe morphology J:60986
abnormal right lung cranial lobe morphology J:60986
cryptorchism J:60986
decreased body size J:60986
impaired righting response J:60986
neonatal lethality, incomplete penetrance J:60986
small lung J:60986
Gli1tm1Alj/Gli1tm1Alj
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal digit morphology J:60986
abnormal lung morphology J:60986
abnormal motor neuron morphology J:60986
abnormal telencephalon morphology J:60986
absent pituitary gland J:60986
lethality throughout fetal growth and development, incomplete penetrance J:60986
perinatal lethality, complete penetrance J:60986
small lung J:60986
Gli1tm2Alj/Gli1+
Gli2tm1Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster 		small lung J:79392
Gli1tm2Alj/Gli1+
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3Xt
involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster 		abnormal motor neuron morphology J:87948
abnormal neuron differentiation J:87948
abnormal neuronal precursor cell number J:87948
abnormal neuronal precursor proliferation J:87948
abnormal spinal cord morphology J:87948
abnormal ventral interneuron 3 morphology J:87948
abnormal ventral interneuron morphology J:87948
absent floor plate J:87948
decreased motor neuron number J:87948
Gli1tm2Alj/Gli1tm2Alj
Gli2tm1Alj/Gli2+
involves: 129 * Black Swiss * Swiss Webster 		abnormal floor plate morphology J:79392
persistence of notochord tissue J:79392
small lung J:79392
Gli1tm2Alj/Gli1tm2Alj
Gli2tm1Alj/Gli2tm1Alj
involves: 129/Sv * Black Swiss * Swiss Webster 		impaired lung lobe morphogenesis J:79392
polydactyly J:79392
small lung J:79392
Gli1tm2Alj/Gli1tm2Alj
Gli2tm3.1(Gli1)Alj/Gli2tm3.1(Gli1)Alj
involves: 129/Sv * Black Swiss * Swiss Webster 		normal nervous system phenotype J:79392
Gli1tm2Alj/Gli1tm2Alj
Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
involves: 129S6/SvEvTac * Swiss Webster 		abnormal ventral interneuron 3 morphology J:87948
absent floor plate J:87948
Gli2tm1(cre/ERT2)Tipe/Gli2+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
involves: 129X1/SvJ 		abnormal bronchioalveolar stem cell morphology J:264185
abnormal pulmonary alveolus morphology J:264185
decreased type II pneumocyte number J:264185
emphysema J:264185
overexpanded pulmonary alveolus J:264185
Gli2tm1Alj/Gli2+
Gli3Xt/Gli3Xt
involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster 		increased neuronal precursor cell number J:87948
Gli2tm1Alj/Gli2+
Gli3Xt-J/Gli3+
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		polydactyly J:38381
Gli2tm1Alj/Gli2+
Gli3Xt-J/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		abnormal skeleton morphology J:38381
fusion of vertebral arches J:38381
polyphalangy J:38381
Gli2tm1Alj/Gli2+
Kif7tm1.2Hui/Kif7tm1.2Hui
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * CD-1 		abnormal neural tube morphology J:152259
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt-J/Gli3+
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		abnormal cartilage development J:38381
abnormal digit morphology J:38381
abnormal long bone morphology J:38381
abnormal skeleton morphology J:38381
abnormal vertebrae development J:38381
mandible hypoplasia J:38381
polydactyly J:38381
short femur J:38381
short fibula J:38381
short humerus J:38381
short radius J:38381
short tibia J:38381
short ulna J:38381
split sternum J:38381
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt-J/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		embryonic lethality, complete penetrance J:38381
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt-J/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster 		abnormal ventral interneuron 0 morphology J:92067
abnormal ventral interneuron 1 morphology J:92067
abnormal ventral interneuron 2 morphology J:92067
abnormal ventral interneuron 3 morphology J:92067
abnormal ventral interneuron morphology J:92067
decreased motor neuron number J:92067
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3+
involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster 		increased neuronal precursor cell number J:87948
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal lung bud morphology J:49603
abnormal lung development J:49603
abnormal lung morphology J:49603
abnormal tracheal cartilage morphology J:49603
esophageal atresia J:49603
pulmonary hypoplasia J:49603
trachea stenosis J:49603
tracheoesophageal fistula J:49603
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3Xt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal endoderm development J:49603
abnormal esophagus development J:49603
abnormal foregut morphology J:49603
abnormal lung development J:49603
abnormal trachea development J:49603
absent esophagus J:49603
absent lungs J:49603
absent trachea J:49603
embryonic lethality during organogenesis, incomplete penetrance J:49603
Gli2tm1Alj/Gli2tm1Alj
Ift122sopb/Ift122sopb
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal neural tube morphology J:168317
Gli2tm1Alj/Gli2tm1Alj
Kif7maki/Kif7maki
Tg(Hlxb9-GFP)1Tmj/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal neural tube morphology J:151965
absent floor plate J:151965
Gli2tm1Alj/Gli2tm1Alj
Pax6Sey/Pax6Sey
involves: 129S1/Sv * 129X1/SvJ 		abnormal neuron differentiation J:112802
Gli2tm1Alj/Gli2tm1Alj
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal brain development J:79392
abnormal spinal cord morphology J:79392
abnormal ventral interneuron 3 morphology J:79392
embryonic lethality during organogenesis, complete penetrance J:79392
exencephaly J:79392
increased motor neuron number J:79392
normal nervous system phenotype J:79392
Gli2tm1Blnw/Gli2tm1Blnw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal maxillary dental arch morphology J:145182
abnormal maxillary frontal process morphology J:145182
abnormal neural tube closure J:145182
abnormal neural tube morphology J:145182
exencephaly J:145182
polydactyly J:145182
prenatal lethality, complete penetrance J:145182
Gli2tm1Blnw/Gli2tm1Blnw
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal cellular phenotype J:145182
normal nervous system phenotype J:145182
Gli2tm2.1Alj/Gli2+
Gli3Xt-J/Gli3Xt-J
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		abnormal mammary gland bud morphology J:112460
Gli2tm2.1Alj/Gli2+
Shhtm1Chg/Shhtm1Chg
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal spinal cord morphology J:73074
abnormal telencephalon development J:73074
decreased embryo size J:73074
Gli2tm2.1Alj/Gli2tm2.1Alj
Gli3Xt-J/Gli3+
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		normal reproductive system phenotype J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj
Gli3Xt-J/Gli3Xt-J
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		embryonic lethality during organogenesis, complete penetrance J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj
Shhtm1Chg/Shhtm1Chg
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal spinal cord interneuron morphology J:73074
absent floor plate J:73074
cyclopia J:73074
decreased motor neuron number J:73074
Gli2tm2.1Alj/Gli2tm2.1Alj
Tmem107schlei/Tmem107schlei
involves: 129S6/SvEvTac * C3HeB/FeJ * C57BL/6J 		abnormal floor plate morphology J:186552
Gli2tm2.1Alj/Gli2tm3(Gli1)Alj
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		no abnormal phenotype detected J:73074
Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		normal nervous system phenotype J:73074
progressive hair loss J:73074
normal respiratory system phenotype J:73074
Gli2tm2.1Alj/Gli2tm3.1(Gli1)Alj
Shhtm1Chg/Shhtm1Chg
either: (involves: 129) or (involves: 129 * Black Swiss) 		abnormal diencephalon morphology J:73074
abnormal ventral interneuron 3 morphology J:73074
absent floor plate J:73074
decreased motor neuron number J:73074
megacephaly J:73074
Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		bradykinesia J:73074
decreased body size J:73074
impaired limb coordination J:73074
postnatal lethality, incomplete penetrance J:73074
premature death J:73074
progressive hair loss J:73074
Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
involves: 129S6/SvEvTac * Black Swiss * Swiss Webster 		normal reproductive system phenotype J:112460
Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Gli3Xt-J/Gli3+
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		abnormal mammary gland bud morphology J:112460
Gli2tm3.1(Gli1)Alj/Gli2+
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		progressive hair loss J:73074
Gli2tm3.1(Gli1)Alj/Gli2+
Gli3Xt-J/Gli3+
either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ) 		male infertility J:73074
polydactyly J:73074
premature death J:73074
progressive hair loss J:73074
Gli2tm3.1(Gli1)Alj/Gli2tm3.1(Gli1)Alj
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		normal nervous system phenotype J:73074
preweaning lethality, complete penetrance J:73074
Gli2tm3.1Blnw/Gli2tm3.1Blnw
Ptch1tm1Mps/?
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6 		abnormal neural tube morphology J:186503
Gli2tm4.1(Gli2)Alj/Gli2tm4.1(Gli2)Alj
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) 		no abnormal phenotype detected J:73074
Gli2tm5(GLI3)Alj/Gli2tm1Alj
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal neural tube morphology J:87948
absent floor plate J:87948
Gli2tm5(GLI3)Alj/Gli2tm5(GLI3)Alj
involves: Swiss Webster 		abnormal floor plate morphology J:87948
abnormal neuron specification J:87948
abnormal ventral interneuron 3 morphology J:87948
Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
involves: Swiss Webster 		abnormal neuron specification J:87948
postnatal lethality, complete penetrance J:87948
Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Gli3Xt/Gli3Xt
involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster 		abnormal ventral interneuron 3 morphology J:87948
absent floor plate J:87948
normal limbs/digits/tail phenotype J:87948
Gli3Xt-J/Gli3Xt-J
Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+
Ihhtm1Amc/Ihhtm1Amc
Tg(Col2a1-cre)3Amc/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ 		abnormal long bone diaphysis morphology J:154905
decreased body size J:154905
perinatal lethality, complete penetrance J:154905
short limbs J:154905
normal skeleton phenotype J:154905
Gt(ROSA)26Sortm1(Gli2)Jmao/Gt(ROSA)26Sor+
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		normal digestive/alimentary phenotype J:199664
Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+
Ihhtm1Amc/Ihhtm1Amc
involves: 129S1/Sv * 129X1/SvJ 		abnormal long bone epiphyseal plate proliferative zone J:154905
abnormal long bone hypertrophic chondrocyte zone J:154905
abnormal osteoblast differentiation J:154905
disorganized long bone epiphyseal plate J:154905
Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+
Ihhtm1Amc/Ihhtm1Amc
Tg(Col2a1-cre)3Amc/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal long bone epiphyseal plate proliferative zone J:154905
abnormal long bone hypertrophic chondrocyte zone J:154905
abnormal osteoblast differentiation J:154905
abnormal perichondrium morphology J:154905
disorganized long bone epiphyseal plate J:154905
perinatal lethality, complete penetrance J:154905
normal skeleton phenotype J:154905
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory