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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gli3
GLI-Kruppel family member GLI3
MGI:95729
171 phenotypes from 20 alleles in 33 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
En1tm2(cre)Wrst/?
Gli3tm1Alj/Gli3tm1Alj
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		abnormal cerebellar foliation J:137136
abnormal hindbrain morphology J:137136
abnormal rhombomere morphology J:137136
abnormal tectum morphology J:137136
enlarged cerebral aqueduct J:137136
enlarged tectum J:137136
normal nervous system phenotype J:137136
Gli3add/Gli3add
involves: C57BL/6 * SJL 		abnormal digit development J:11318
Gli3Mos1/Gli3+
involves: BALB/cJ * C57BL/6J 		belly spot J:136642
hypopigmentation J:136642
Gli3Mos1/Gli3+
Tg(Dct-lacZ)A12Jkn/0
involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA 		abnormal melanoblast morphology J:136642
Gli3Mos1/Gli3Mos1
involves: BALB/cJ * C57BL/6J 		abnormal melanoblast morphology J:136642
embryonic lethality J:136642
Gli3Mos1/Gli3Mos1
Tg(Dct-lacZ)A12Jkn/0
involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA 		abnormal melanoblast morphology J:136642
abnormal telencephalon development J:136642
Gli3Mos1/Gli3Xt-J
involves: BALB/cJ * C3H/HeJ * C57BL/6J 		postnatal lethality J:136642
Gli3Pdn/Gli3+
involves: Jcl:ICR 		abnormal digit morphology J:12736
polydactyly J:12736
Gli3Pdn/Gli3Pdn
involves: Jcl:ICR 		abnormal cerebral cortex morphology J:43330
abnormal cerebral hemisphere morphology J:38885
abnormal digit morphology J:12736
abnormal hippocampal fornix morphology J:17581
abnormal hippocampus development J:17581, J:38885
abnormal hippocampus pyramidal cell layer J:17581
abnormal hypothalamus morphology J:17581
abnormal neuronal migration J:43330
abnormal olfactory nerve morphology J:17581, J:38885
abnormal radial glial cell morphology J:43330
abnormal stratification in cerebral cortex J:38885
abnormal thalamus morphology J:17581
absent anterior commissure J:17581, J:38885
absent corpus callosum J:17581, J:38885
absent hippocampal commissure J:38885
absent olfactory bulb J:17581, J:38885, J:43330
absent pineal gland J:17581
cleft palate J:12736
encephalomeningocele J:17581
exencephaly J:12736
eyelids open at birth J:12736
hydrocephaly J:17581, J:38885
polydactyly J:12736
postnatal lethality J:12736
short fibula J:12736
short tibia J:12736
split sternal manubrium J:12736
spongiform encephalopathy J:17581, J:38885
synostosis J:12736
thin cerebral cortex J:43330
Gli3TgBR/Gli3+
involves: C57BL/6J 		hydrocephaly J:77245
preaxial polydactyly J:77245
Gli3TgBR/Gli3TgBR
involves: C57BL/6J 		abnormal craniofacial morphology J:77245
abnormal limb morphology J:77245
abnormal skeleton morphology J:77245
absent optic nerve J:77245
anophthalmia J:77245
exencephaly J:77245
herniated abdominal wall J:77245
microphthalmia J:77245
perinatal lethality J:77245
polydactyly J:77245
respiratory distress J:77245
Gli3tm1.1Alj/Gli3tm1.1Alj
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebellar Purkinje cell layer J:137136
abnormal cerebellum morphology J:137136
abnormal hindbrain morphology J:137136
abnormal inferior colliculus morphology J:137136
abnormal midbrain morphology J:137136
abnormal midbrain-hindbrain boundary morphology J:137136
abnormal superior colliculus morphology J:137136
enlarged cerebral aqueduct J:137136
enlarged tectum J:137136
reduced cerebellar foliation J:137136
Gli3tm1.1Zllr/Gli3tm1.2Zllr
Hoxa13tm1.1(cre)Makm/Hoxa13+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		polydactyly J:184012
Gli3tm1.2Zllr/Gli3tm1.2Zllr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal endochondral bone ossification J:199462
absent tibia J:199462
hemimelia J:199462
polydactyly J:199462
Gli3tm1.2Zllr/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J * NMRI 		abnormal brain morphology J:184012
abnormal eye morphology J:184012
polydactyly J:184012
Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		normal digestive/alimentary phenotype J:199664
normal mortality/aging J:199664
Gli3tm1Alj/Gli3tm1Alj
Tg(Nes-cre)1Kln/?
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal midbrain-hindbrain boundary morphology J:137136
enlarged tectum J:137136
normal nervous system phenotype J:137136
Gli3tm1Blnw/Gli3tm1Blnw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		polydactyly J:118340
Gli3tm1Blnw/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 		polydactyly J:118340
postnatal lethality, complete penetrance J:118340
Gli3tm1Urt/Gli3+
either: 129P2/OlaHsd-Gli3Tm1Urt or (involves: 129P2/OlaHsd * C57BL/6) 		polydactyly J:76496
Gli3tm1Urt/Gli3tm1Urt
involves: 129P2/OlaHsd 		normal pigmentation phenotype J:136642
Gli3tm1Urt/Gli3tm1Urt
involves: 129P2/OlaHsd * C57BL/6 		abnormal basisphenoid bone morphology J:76496
abnormal bone mineralization J:76496
abnormal colon morphology J:76496
abnormal intestine morphology J:76496
abnormal kidney morphology J:76496
abnormal laryngeal cartilage morphology J:76496
abnormal limb morphology J:199480
abnormal nail morphology J:76496
abnormal palatine bone horizontal plate morphology J:76496
abnormal spine curvature J:76496
abnormal vertebrae morphology J:76496
absent adrenal gland J:76496
absent epiglottis J:76496
anal atresia J:76496
basisphenoid bone foramen J:76496
bowed radius J:76496
bowed tibia J:76496
bowed ulna J:76496
camptomelia J:76496
embryonic growth retardation J:76496
enlarged cranium J:76496
failure of endochondral bone ossification J:199480
interdigital webbing J:76496
neonatal lethality, complete penetrance J:76496
polydactyly J:76496
polysyndactyly J:199480
short limbs J:76496
short tibia J:199480
single kidney J:76496
small basisphenoid bone J:76496
syndactyly J:76496
vertebral fusion J:76496
Gli3tm1Urt/Gli3tm2Blnw
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		polydactyly J:121609
Gli3tm2Blnw/Gli3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		polydactyly J:121609
Gli3tm2Blnw/Gli3tm2Blnw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal digit morphology J:121609
abnormal phalanx morphology J:121609
absent tibia J:121609
perinatal lethality, complete penetrance J:121609
polydactyly J:121609
short tibia J:121609
synostosis J:121609
Gli3tm3.1Blnw/Gli3+
Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL 		abnormal autopod morphology J:199480
abnormal forelimb zeugopod morphology J:199480
abnormal hindlimb morphology J:199480
bowed radius J:199480
bowed ulna J:199480
brachydactyly J:199480
decreased autopod size J:199480
failure of endochondral bone ossification J:199480
oligodactyly J:199480
short femur J:199480
short fibula J:199480
short forelimb J:199480
short humerus J:199480
short radius J:199480
short scapula J:199480
short tibia J:199480
short ulna J:199480
syndactyly J:199480
Gli3tm3.1Blnw/Gli3tm3.1Blnw
involves: 129S6/SvEvTac * C57BL/6 * SJL 		no abnormal phenotype detected J:199480
Gli3tm3.1Blnw/Gli3tm3.1Blnw
Tg(Prrx1-cre)1Cjt/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL 		abnormal autopod morphology J:199480
abnormal forelimb zeugopod morphology J:199480
abnormal limb morphology J:199480
absent radius J:199480
absent ulna J:199480
adactyly J:199480
failure of endochondral bone ossification J:199480
oligodactyly J:199480
perinatal lethality, incomplete penetrance J:199480
short fibula J:199480
short forelimb J:199480
short hindlimb J:199480
short humerus J:199480
short limbs J:199480
short scapula J:199480
short tibia J:199480
Gli3Xt-2H/Gli3+
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
Gli3Xt-2H/Gli3Xt-2H
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
abnormal phalanx morphology J:5053
polydactyly J:5053
Gli3Xt-3H/Gli3+
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053, J:5123
abnormal facial morphology J:5123
abnormal hallux morphology J:5053, J:5123
abnormal interfrontal bone morphology J:5123
abnormal sternum morphology J:5123
belly spot J:5123
brachyphalangia J:5053
polysyndactyly J:5053
short sternum J:5123
sternebra fusion J:5123
syndactyly J:5123
Gli3Xt-3H/Gli3Xt-3H
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
bilateral cleft upper lip J:5123
bleb J:5123
brachyphalangia J:64111
edema J:5123
exencephaly J:5123
polydactyly J:64111
prenatal lethality J:64111
unilateral cleft upper lip J:5123
Gli3Xt-4H/Gli3+
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
Gli3Xt-4H/Gli3Xt-4H
involves: 101/H * C3H/HeH 		embryonic lethality before implantation, complete penetrance J:5053
Gli3Xt-5H/Gli3+
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
Gli3Xt-5H/Gli3Xt-5H
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
abnormal phalanx morphology J:5053
polydactyly J:5053
Gli3Xt-6H/Gli3+
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
Gli3Xt-6H/Gli3Xt-6H
involves: 101/H * C3H/HeH 		abnormal digit morphology J:5053
abnormal phalanx morphology J:5053
polydactyly J:5053
Gli3Xt-7H/Gli3Xt-7H
mixed 		abnormal digit morphology J:5053
Gli3Xt-J/Gli3+
C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J 		polydactyly J:27442
Gli3Xt-J/Gli3+
involves: 129/Sv * C3H/HeJ * C57BL/6 		polyphalangy J:121609
Gli3Xt-J/Gli3+
involves: C3H * CD-1 		abnormal embryonic autopod plate morphology J:4086
polydactyly J:38381
Gli3Xt-J/Gli3+
involves: C3H/HeJ 		polydactyly J:207959
Gli3Xt-J/Gli3+
involves: C3H/HeJ * C57BL/6J * C57BL/6NHsd 		polydactyly J:42445
Gli3Xt-J/Gli3Xt-J
B6.C3-Gli3Xt-J/J 		abnormal embryonic tissue morphology J:109476
abnormal epidermis stratum basale morphology J:109476
abnormal lambdoid suture morphology J:163175
abnormal left lung morphology J:42454
abnormal mammary gland bud morphology J:109476
abnormal mammary line morphology J:109476
abnormal neurocranium morphology J:163175
abnormal right lung accessory lobe morphology J:42454
abnormal right lung caudal lobe morphology J:42454
abnormal right lung middle lobe morphology J:42454
decreased lung weight J:42454
edema J:42454
embryonic lethality during organogenesis, incomplete penetrance J:42454
increased embryo size J:42454
increased forebrain size J:163175
premature lambdoid suture closure J:163175
small lung J:42454
wide metopic suture J:163175
wide sagittal suture J:163175
Gli3Xt-J/Gli3Xt-J
involves: 129/Sv * C3H/HeJ * C57BL/6 		abnormal digit morphology J:121609
abnormal phalanx morphology J:121609
absent tibia J:121609
polydactyly J:121609
Gli3Xt-J/Gli3Xt-J
involves: 129/Sv * C3H/HeJ * C57BL/6J 		polydactyly J:121554
Gli3Xt-J/Gli3Xt-J
involves: C3H * CD-1 		abnormal brain morphology J:4086
abnormal craniofacial development J:4086
abnormal cranium morphology J:38381
abnormal ear position J:4086
abnormal embryonic autopod plate morphology J:4086
abnormal eye development J:4086
abnormal long bone morphology J:38381
abnormal maxilla morphology J:38381
abnormal sternum morphology J:38381
abnormal tooth development J:38381
abnormal vertebral arch morphology J:38381
abnormal vibrissa morphology J:4086
abnormal vibrissa number J:4086
absent neurocranium J:38381
cleft palate J:38381
edema J:4086
exencephaly J:4086
incomplete rostral neuropore closure J:4086
increased diameter of humerus J:38381
increased diameter of radius J:38381
increased diameter of ulna J:38381
perinatal lethality, complete penetrance J:4086
polydactyly J:4086, J:38381
prenatal lethality, incomplete penetrance J:4086
short humerus J:38381
short radius J:38381
short tibia J:38381
short ulna J:38381
syndactyly J:4086
Gli3Xt-J/Gli3Xt-J
involves: C3H/HeJ 		polydactyly J:159210
Gli3Xt-J/Gli3Xt-J
involves: C3H/HeJ * C57BL/6 		abnormal left lung morphology J:42454
abnormal mammary gland bud morphology J:112460
abnormal right lung accessory lobe morphology J:42454
abnormal right lung caudal lobe morphology J:42454
normal mortality/aging J:42454
small lung J:42454
Gli3Xt-J/Gli3Xt-J
involves: C3H/HeJ * CD-1 		abnormal sternum morphology J:152259
abnormal xiphoid process morphology J:152259
edema J:152259
exencephaly J:152259
polydactyly J:152259
Gli3Xt-J/Gli3Xt-J
involves: C3H/HeJ * NMRI 		polydactyly J:184012
Gli3Xt-J/Gli3Xt-J
Tg(TCF/Lef1-lacZ)34Efu/0
involves: C3H/HeJ * C57BL/6 		abnormal mammary gland embryonic development J:112460
abnormal mammary placode morphology J:112460
Gt(ROSA)26Sortm3(Gli3)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6J * CBA * SJL/J * Swiss Webster 		decreased bone mineral density J:143454
polydactyly J:143454
short limbs J:143454
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory