About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gli3
GLI-Kruppel family member GLI3
MGI:95729
185 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Bmp4tm1Blh/Bmp4+
Gli3Xt-J/Gli3+
involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd 		abnormal autopod morphology J:42445
polydactyly J:42445
Cdk20tm1.1Jegg/Cdk20tm1.1Jegg
Gli3Xt-J/Gli3+
involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N 		abnormal neural tube morphology J:243907
Cdk20tm1.1Jegg/Cdk20tm1.1Jegg
Gli3Xt-J/Gli3Xt-J
involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N 		normal embryo phenotype J:243907
En1tm2(cre)Wrst/?
Gli3tm1Alj/Gli3tm1Alj
Smotm2Amc/Smotm2Amc
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		abnormal cerebellar foliation J:137136
abnormal cerebellum morphology J:137136
abnormal hindbrain morphology J:137136
abnormal rhombomere morphology J:137136
abnormal tectum morphology J:137136
enlarged cerebral aqueduct J:137136
enlarged tectum J:137136
normal nervous system phenotype J:137136
small cerebellum J:137136
thin external granule cell layer J:137136
Fgf8tm1.4Mrt/Fgf8+
Gli3tm1.1Alj/Gli3tm1.1Alj
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 		absent inferior colliculus J:137136
enlarged tectum J:137136
normal nervous system phenotype J:137136
Gas1tm2Fan/Gas1tm2Fan
Gli3Xt-J/Gli3Xt-J
involves: 129/Sv * C3H/HeJ * C57BL/6J 		polydactyly J:121554
Gli1tm1Alj/Gli1tm1Alj
Gli3Xt-J/Gli3+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		polydactyly J:60986
Gli1tm2Alj/Gli1+
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3Xt
involves: 101/H * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster 		abnormal motor neuron morphology J:87948
abnormal neuron differentiation J:87948
abnormal neuronal precursor cell number J:87948
abnormal neuronal precursor proliferation J:87948
abnormal spinal cord morphology J:87948
abnormal ventral interneuron 3 morphology J:87948
abnormal ventral interneuron morphology J:87948
absent floor plate J:87948
decreased motor neuron number J:87948
Gli2tm1Alj/Gli2+
Gli3Xt/Gli3Xt
involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster 		increased neuronal precursor cell number J:87948
Gli2tm1Alj/Gli2+
Gli3Xt-J/Gli3+
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		polydactyly J:38381
Gli2tm1Alj/Gli2+
Gli3Xt-J/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		abnormal skeleton morphology J:38381
fusion of vertebral arches J:38381
polyphalangy J:38381
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt-J/Gli3+
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		abnormal cartilage development J:38381
abnormal digit morphology J:38381
abnormal long bone morphology J:38381
abnormal skeleton morphology J:38381
abnormal vertebrae development J:38381
mandible hypoplasia J:38381
polydactyly J:38381
short femur J:38381
short fibula J:38381
short humerus J:38381
short radius J:38381
short tibia J:38381
short ulna J:38381
split sternum J:38381
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt-J/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1 		embryonic lethality, complete penetrance J:38381
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt-J/Gli3Xt-J
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster 		abnormal ventral interneuron 0 morphology J:92067
abnormal ventral interneuron 1 morphology J:92067
abnormal ventral interneuron 2 morphology J:92067
abnormal ventral interneuron 3 morphology J:92067
abnormal ventral interneuron morphology J:92067
decreased motor neuron number J:92067
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3+
involves: 101/H * 129S1/Sv * 129X1/SvJ * C3H/HeH * C57BL * CBA/H * Swiss Webster 		increased neuronal precursor cell number J:87948
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal lung bud morphology J:49603
abnormal lung development J:49603
abnormal lung morphology J:49603
abnormal tracheal cartilage morphology J:49603
esophageal atresia J:49603
pulmonary hypoplasia J:49603
trachea stenosis J:49603
tracheoesophageal fistula J:49603
Gli2tm1Alj/Gli2tm1Alj
Gli3Xt/Gli3Xt
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal endoderm development J:49603
abnormal esophagus development J:49603
abnormal foregut morphology J:49603
abnormal lung development J:49603
abnormal trachea development J:49603
absent esophagus J:49603
absent lungs J:49603
absent trachea J:49603
embryonic lethality during organogenesis, incomplete penetrance J:49603
Gli2tm2.1Alj/Gli2+
Gli3Xt-J/Gli3Xt-J
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		abnormal mammary gland bud morphology J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj
Gli3Xt-J/Gli3+
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		normal reproductive system phenotype J:112460
Gli2tm2.1Alj/Gli2tm2.1Alj
Gli3Xt-J/Gli3Xt-J
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		embryonic lethality during organogenesis, complete penetrance J:112460
Gli2tm3(Gli1)Alj/Gli2tm3(Gli1)Alj
Gli3Xt-J/Gli3+
involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster 		abnormal mammary gland bud morphology J:112460
Gli2tm3.1(Gli1)Alj/Gli2+
Gli3Xt-J/Gli3+
either: (involves: 129S6/SvEvTac * C3H/HeJ) or (involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ) 		male infertility J:73074
polydactyly J:73074
premature death J:73074
progressive hair loss J:73074
Gli2tm5.1(GLI3)Alj/Gli2tm5.1(GLI3)Alj
Gli3Xt/Gli3Xt
involves: 101/H * C3H/HeH * C57BL * CBA/H * Swiss Webster 		abnormal ventral interneuron 3 morphology J:87948
absent floor plate J:87948
normal limbs/digits/tail phenotype J:87948
Gli3add/Gli3Xt
involves: 101/H * C3H/HeH * C57BL/6 * CBA/H * SJL 		abnormal digit development J:11318
polydactyly J:11318
Gli3Mos1/Gli3+
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J 		belly spot J:136642
belted J:136642
hypopigmentation J:136642
Gli3TgBR/Gli3+
ScribCrc/ScribCrc
involves: C57BL/6J * NMRI 		abnormal innervation J:77245
Gli3TgBR/Gli3Xt
involves: 101/H * C3H/HeH * C57BL/6J * CBA/H 		abnormal skeleton morphology J:77245
polydactyly J:77245
Gli3tm1.1Alj/Gli3Xt
involves: 101/H * 129S6/SvEvTac * C3H/HeH * C57BL/6 * CBA/H 		abnormal cerebellar Purkinje cell layer J:137136
abnormal cerebellum morphology J:137136
abnormal hindbrain morphology J:137136
abnormal inferior colliculus morphology J:137136
abnormal midbrain morphology J:137136
abnormal rhombomere morphology J:137136
abnormal superior colliculus morphology J:137136
enlarged cerebral aqueduct J:137136
enlarged tectum J:137136
reduced cerebellar foliation J:137136
Gli3tm1.2Zllr/Gli3+
Pkdcctm1.2Azun/Pkdcctm1.2Azun
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal scapula morphology J:199462
decreased length of long bones J:199462
delayed endochondral bone ossification J:199462
short humerus J:199462
short tibia J:199462
Gli3tm1.2Zllr/Gli3tm1.2Zllr
Pkdcctm1.2Azun/Pkdcctm1.2Azun
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cartilage development J:199462
abnormal scapula morphology J:199462
absent fibula J:199462
absent tibia J:199462
delayed endochondral bone ossification J:199462
polydactyly J:199462
Gli3tm1Alj/Gli3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA 		abnormal cephalic neural fold morphology J:183402
abnormal forebrain development J:183402
abnormal olfactory epithelium morphology J:183402
decreased embryonic neuroepithelial cell proliferation J:183402
exencephaly J:183402
Gli3tm1Alj/Gli3tm1Alj
Nkx3-2tm1(cre)Wez/Nkx3-2+
Smotm2Amc/Smotm2Amc
involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ 		abnormal digestive system morphology J:199664
Gli3tm1Urt/Gli3tm1Urt
Sufutm1.1Blnw/Sufutm1.1Blnw
involves: 129 * C57BL/6 * CD-1 * FVB/N 		normal nervous system phenotype J:161408
Gli3tm2Blnw/Gli3+
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal autopod morphology J:121609
abnormal digit morphology J:121609
abnormal limb morphology J:121609
abnormal phalanx morphology J:121609
absent tibia J:121609
polydactyly J:121609
short tibia J:121609
synostosis J:121609
Gli3Xt-J/Gli3+
Sox10tm1Weg/Sox10+
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ 		belly spot J:136642
belted J:136642
hypopigmentation J:136642
Gli3Xt-J/Gli3+
Tulp3hhkr/Tulp3+
involves: C3H/HeH * C3H/HeJ * C57BL/6 		polydactyly J:147584
Gli3Xt-J/Gli3+
Tulp3hhkr/Tulp3hhkr
involves: C3H/HeH * C3H/HeJ * C57BL/6 		polydactyly J:147584
Gli3Xt-J/Gli3+
Rr26tm1Svok/Rr26+
involves: 129X1/SvJ * C3H/HeJ 		polydactyly J:207959
Gli3Xt-J/Gli3+
Rr26tm1Svok/Rr26tm1Svok
involves: 129X1/SvJ * C3H/HeJ 		polydactyly J:207959
Gli3Xt-J/Gli3+
Spoptm1c(KOMP)Mbp/Spoptm1c(KOMP)Mbp
Tg(Prrx1-cre)1Cjt/0
involves: C3H/HeJ * C57BL/6J * C57BL/6N * SJL/J 		normal skeleton phenotype J:239074
Gli3Xt-J/Gli3Xt-J
Gt(ROSA)26Sortm2(Gli2*)Flng/Gt(ROSA)26Sor+
Ihhtm1Amc/Ihhtm1Amc
Tg(Col2a1-cre)3Amc/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ 		abnormal long bone diaphysis morphology J:154905
decreased body size J:154905
perinatal lethality, complete penetrance J:154905
short limbs J:154905
normal skeleton phenotype J:154905
Gli3Xt-J/Gli3Xt-J
Hand2tm1.1Zllr/Hand2tm1.2Zllr
Tg(Prrx1-cre)1Cjt/0
involves: 129 * BALB/cJ * C3H/HeJ * C57BL/6 * SJL 		abnormal autopod morphology J:159210
abnormal forelimb stylopod morphology J:159210
abnormal forelimb zeugopod morphology J:159210
abnormal limb development J:159210
postaxial polydactyly J:159210
preaxial polydactyly J:159210
Gli3Xt-J/Gli3Xt-J
Ihhtm1Amc/Ihhtm1Amc
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ 		abnormal bone marrow cavity morphology J:154905
abnormal perichondrium morphology J:154905
Gli3Xt-J/Gli3Xt-J
Skitm1Cco/Ski+
involves: C3H * C57BL/6 		abnormal skeleton development J:80205
polydactyly J:80205
Gli3Xt-J/Gli3Xt-J
Tbx15de-H/Tbx15+
involves: C3H * C57BL/6J 		abnormal scapula morphology J:101708
scapular bone foramen J:101708
Gli3Xt-J/Gli3Xt-J
Tbx15de-H/Tbx15de-H
involves: C3H * C57BL/6J 		small acromion J:101708
small scapula J:101708
Gli3Xt-J/Gli3Xt-J
Tmem107schlei/Tmem107schlei
involves: C3H/HeJ * C3HeB/FeJ * C57BL/6J 		abnormal floor plate morphology J:186552
Gli3Xt-J/Gli3Xt-J
Tulp3hhkr/Tulp3+
involves: C3H/HeH * C3H/HeJ * C57BL/6 		polysyndactyly J:147584
Gli3Xt-J/Gli3Xt-J
Tulp3hhkr/Tulp3hhkr
involves: C3H/HeH * C3H/HeJ * C57BL/6 		lethality throughout fetal growth and development, complete penetrance J:147584
Gli3Xt/Gli3+
involves: 101/H * 129 * C3H/HeH * C57BL/6 		abnormal digit morphology J:121609
abnormal phalanx morphology J:121609
absent tibia J:121609
polydactyly J:121609
Gli3Xt/Gli3Xt
involves: 101/H * 129 * C3H/HeH * C57BL/6 * CBA/H 		abnormal digit morphology J:121609
polydactyly J:121609
Gli3Xt/Gli3Xt
involves: 101/H * C3H/HeH * C57BL/6 * CBA/H 		abnormal cerebellar Purkinje cell layer J:137136
abnormal cerebellum morphology J:137136
abnormal cerebral hemisphere morphology J:19818
abnormal choroid plexus morphology J:19818
abnormal folding of telencephalic vesicles J:19818
abnormal forebrain morphology J:19818
abnormal hindbrain morphology J:137136
abnormal inferior colliculus morphology J:137136
abnormal lateral ventricle morphology J:19818
abnormal midbrain morphology J:137136
abnormal rhombomere morphology J:137136
abnormal superior colliculus morphology J:137136
abnormal telencephalon development J:19818
absent olfactory bulb J:19818
delayed neural tube closure J:19818
enlarged cerebral aqueduct J:137136
enlarged tectum J:137136
incomplete rostral neuropore closure J:19818
normal nervous system phenotype J:19818
reduced cerebellar foliation J:137136
Gli3Xt/Gli3Xt
involves: 101/H * C3H/HeH * CBA/H 		abnormal anterior cardinal vein morphology J:5049
abnormal axial skeleton morphology J:5049
abnormal brain morphology J:5049
abnormal cerebellum morphology J:5049
abnormal cerebral hemisphere morphology J:5049
abnormal cranial ganglia morphology J:5049
abnormal cranium morphology J:5049
abnormal epidermal layer morphology J:5049
abnormal eye development J:5049
abnormal forebrain morphology J:5049
abnormal forehead morphology J:5049
abnormal hindbrain morphology J:5049
abnormal hindlimb morphology J:5049
abnormal inner ear development J:5049
abnormal interfrontal bone morphology J:5049
abnormal kidney morphology J:5049
abnormal limb bone morphology J:5049
abnormal limb bud morphology J:5049
abnormal long bone morphology J:5049
abnormal maxilla morphology J:5049
abnormal medulla oblongata morphology J:5049
abnormal metacarpal bone morphology J:5049
abnormal metatarsal bone morphology J:5049
abnormal midbrain morphology J:5049
abnormal nasal cartilage morphology J:5049
abnormal nasal cavity morphology J:5049
abnormal nasal placode morphology J:5049
abnormal nasal septum morphology J:5049
abnormal neural tube morphology J:5049
abnormal neurocranium morphology J:5049
abnormal nose morphology J:5049
abnormal olfactory epithelium morphology J:5049
abnormal olfactory nerve morphology J:5049
abnormal olfactory tract morphology J:5049
abnormal optic chiasm morphology J:5049
abnormal optic cup morphology J:5049
abnormal optic stalk morphology J:5049
abnormal optic vesicle formation J:5049
abnormal orbitosphenoid bone morphology J:5049
abnormal otic capsule morphology J:5049
abnormal otic vesicle development J:5049
abnormal pericardium morphology J:5049
abnormal phalanx morphology J:5049
abnormal pharyngeal arch morphology J:5049
abnormal pubis morphology J:5049
abnormal rhombomere morphology J:5049
abnormal spine curvature J:5049
abnormal sternum morphology J:5049
abnormal superior semicircular canal morphology J:5049
abnormal telencephalon development J:5049
absent lateral semicircular canal J:5049
absent olfactory bulb J:5049
absent pineal gland J:5049
absent radius J:5049
absent tibia J:5049
acoria J:5049
anophthalmia J:5049
bowed fibula J:5049
decreased nipple number J:5049
delayed neural tube closure J:5049
ectopic adrenal gland J:5049
ectopic ovary J:5049
embryonic lethality during organogenesis, incomplete penetrance J:5049
enlarged first pharyngeal arch J:5049
eyelids fail to open J:5049
fused carpal bones J:5049
fused tarsal bones J:5049
fusion of vertebral arches J:5049
Harderian gland hyperplasia J:5049
hemorrhage J:5049
increased total retina thickness J:5049
microphthalmia J:5049
omphalocele J:5049
polydactyly J:5049
prenatal lethality, incomplete penetrance J:5049
retina fold J:5049
sacral vertebral fusion J:5049
short femur J:5049
short nasal septum J:5049
skin edema J:5049
syndactyly J:5049
thick apical ectodermal ridge J:5049
thick nasal septum J:5049
wavy neural tube J:5049
Gli3Xt/Gli3Xt
Glis1tm1Mnks/Glis1tm1Mnks
mixed 		abnormal brain morphology J:80052
polydactyly J:80052
Gli3Xt/?
Kif7maki/Kif7maki
Tg(Hlxb9-GFP)1Tmj/?
involves: 101/H * C3H/HeH * C57BL/6J * CBA/H * FVB/N 		abnormal neural tube morphology J:151965
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory