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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Glra1
glycine receptor, alpha 1 subunit
MGI:95747
50 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Glra1m1Cpai/Glra1m1Cpai
involves: 129 * C57BL/6 		abnormal CNS synaptic transmission J:248717
abnormal inhibitory postsynaptic currents J:248717
abnormal miniature inhibitory postsynaptic currents J:248717
abnormal motor capabilities/coordination/movement J:248717
abnormal tail movements J:248717
decreased body size J:248717
decreased miniature inhibitory postsynaptic current amplitude J:248717
decreased miniature inhibitory postsynaptic current frequency J:248717
impaired coordination J:248717
impaired righting response J:248717
limb grasping J:248717
muscle spasm J:248717
premature death J:248717
tremors J:248717
Glra1m1Cpai/Glra1spd-ot
involves: 129 * C57BL/6 * C57BL/6J 		preweaning lethality, complete penetrance J:248717
Glra1m1Cpai/Glra1spd
involves: 129 * A/HeJ * C57BL/6 		abnormal motor capabilities/coordination/movement J:248717
Glra1nmf11/Glra1nmf11
C57BL/6J-Glra1nmf11/J 		abnormal eye electrophysiology J:78134
abnormal gait J:78134
decreased white adipose tissue amount J:78134
premature death J:78134
seizures J:78134
small spleen J:78134
thymus atrophy J:78134
tremors J:78134
Glra1spd-ot9J/Glra1spd-ot9J
B6.Cg-Glra1spd-ot9J/GrsrJ 		decreased body size J:234690
preweaning lethality, complete penetrance J:234690
tonic-clonic seizures J:234690
Glra1spd-ot/Glra1spd-ot
C57BL/6J-Glra1spd-ot Mpzl3rc 		postnatal lethality, incomplete penetrance J:13463
tremors J:13463
Glra1spd-ot/Glra1spd-ot
involves: C57BL/6J 		abnormal nervous system electrophysiology J:107942
abnormal pulmonary respiratory rate J:107942
decreased neuron number J:107942
muscle spasm J:107942
normal nervous system phenotype J:132622
postnatal lethality J:107942
Glra1spd/Glra1+
B6C3Fe a/a-Glra1spd/J 		impaired acrosome reaction J:107699
impaired fertilization J:107699
Glra1spd/Glra1spd
B6C3Fe a/a-Glra1spd/J 		abnormal gait J:9027
abnormal posture J:9027
hyperactivity J:20373
impaired acrosome reaction J:107699
impaired fertilization J:107699
impaired righting response J:9027
limb grasping J:9027
male infertility J:9027
muscle hypertonia J:20373
tremors J:9027
Glra1spd/Glra1spd
involves: A/HeJ 		abnormal startle reflex J:33924
hyperekplexia J:33924
increased startle reflex J:33924
Glra1tm1.1Geh/Glra1tm1.1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL 		abnormal righting response J:177105
decreased body weight J:177105
impaired coordination J:177105
increased startle reflex J:177105
increased susceptibility to pharmacologically induced seizures J:177105
tremors J:177105
Glra1tm1Betz/Glra1tm1Betz
B6.129P2-Glra1tm1Betz 		abnormal cone electrophysiology J:117236
abnormal gait J:117236
abnormal inhibitory postsynaptic currents J:117236
abnormal single cell response J:117236
decreased body weight J:117236
impaired righting response J:117236
increased b-wave amplitude J:117236
increased startle reflex J:117236
limb grasping J:117236
normal mortality/aging J:117236
muscle hypertonia J:117236
normal reproductive system phenotype J:117236
short stride length J:117236
tremors J:117236
Glra1tm1Rah/Glra1+
involves: 129X1/SvJ * C57BL/6J 		abnormal channel response J:85341
normal behavior/neurological phenotype J:85341
increased startle reflex J:85341
limb grasping J:85341
Glra1tm1Rah/Glra1tm1Rah
involves: 129X1/SvJ * C57BL/6J 		postnatal lethality, complete penetrance J:85341
seizures J:85341
Glra1tm2.1Geh/Glra1tm2.1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL 		abnormal righting response J:177106
ataxia J:177106
decreased body weight J:177106
impaired coordination J:177106
increased startle reflex J:177106
increased susceptibility to pharmacologically induced seizures J:177106
tremors J:177106
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/03/2024
MGI 6.24 		The Jackson Laboratory