Glrb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Glrb
glycine receptor, beta subunit
MGI:95751

40 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Glrb^em1(IMPC)Tcp/Glrb⁺ C57BL/6NCrl-Glrb^em1(IMPC)Tcp/Tcp	decreased circulating alkaline phosphatase level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased freezing behavior	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased heart weight	J:211773
	increased neutrophil cell number	J:211773
	increased spleen weight	J:211773
Glrb^em1(IMPC)Tcp/Glrb^em1(IMPC)Tcp C57BL/6NCrl-Glrb^em1(IMPC)Tcp/Tcp	preweaning lethality, complete penetrance	J:211773
Glrb^spa-Alb/Glrb^spa-Alb C57BL/6Fla-H2-T18^a	abnormal gait	J:64454
	abnormal motor capabilities/coordination/movement	J:64454
	impaired righting response	J:64454
	muscle hypertonia	J:64454
	preweaning lethality, complete penetrance	J:64454
	tremors	J:64454
Glrb^spa/Glrb⁺ B6C3Fe a/a-Glrb^spa/J	impaired acrosome reaction	J:107699
Glrb^spa/Glrb⁺ B6C3Fe a/a-Glrb^spa/J	impaired fertilization	J:107699
Glrb^spa/Glrb^spa B6C3Fe a/a-Glrb^spa/J	impaired acrosome reaction	J:107699
Glrb^spa/Glrb^spa B6C3Fe a/a-Glrb^spa/J	impaired fertilization	J:107699
Glrb^spa/Glrb^spa involves: C3HeB/FeLe * C57BL/6 * C57BL/6J * DBA/2	hyperekplexia	J:60037
	impaired righting response	J:60037
	limb grasping	J:60037
	muscle hypertonia	J:60037
	reduced male fertility	J:60037
	tremors	J:60037
Glrb^spa/Glrb^spa Not Specified	abnormal adrenal cortex morphology	J:5196
	abnormal brain dura mater morphology	J:5196
	abnormal dorsal root ganglion morphology	J:5196
	abnormal gait	J:13079
	abnormal intervertebral disk morphology	J:5196
	abnormal maternal nurturing	J:13079
	abnormal posture	J:13079
	abnormal Purkinje cell morphology	J:5196
	abnormal spinal cord morphology	J:5196
	abnormal spinal cord ventral horn morphology	J:5196
	abnormal spinal nerve morphology	J:5196
	abnormal vertebral column morphology	J:5196
	decreased body size	J:5196
	edema	J:5196
	enlarged adrenal glands	J:5196
	fragile skeleton	J:5196
	hemorrhage	J:5196
	hyperekplexia	J:33924
	impaired righting response	J:13079
	impaired swimming	J:13079
	increased startle reflex	J:33924
	muscle spasm	J:5196, J:13079
	postnatal lethality, incomplete penetrance	J:13079
	reduced male fertility	J:13079
	short stride length	J:13079
	tremors	J:5196

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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