Gnb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gnb1
guanine nucleotide binding protein (G protein), beta 1
MGI:95781

37 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gnb1^em1(IMPC)Bay/Gnb1⁺ C57BL/6N-Gnb1^em1(IMPC)Bay/Bay	abnormal retina outer nuclear layer morphology	J:211773
	decreased anxiety-related response	J:211773
	decreased total retina thickness	J:211773
	hyperactivity	J:211773
	increased bone mineral content	J:211773
	increased vertical activity	J:211773
Gnb1^em1(IMPC)Bay/Gnb1^em1(IMPC)Bay C57BL/6N-Gnb1^em1(IMPC)Bay/Bay	facial cleft	J:211773
	preweaning lethality, complete penetrance	J:211773
Gnb1^em1Dgold/Gnb1⁺ C57BL/6NJ-Gnb1^em1Dgold	abnormal locomotor behavior	J:346983
	abnormal long-term spatial reference memory	J:346983
	abnormal maternal behavior	J:346983
	abnormal spike wave discharge	J:346983
	normal behavior/neurological phenotype	J:346983
	decreased body size	J:346983
	decreased body weight	J:346983
	decreased locomotor activity	J:346983
	decreased vocalization	J:346983
	impaired righting response	J:346983
	impaired spatial learning	J:346983
	minimal clonic seizures	J:346983
Gnb1^em1Dgold/Gnb1⁺ involves: 129P2/OlaHsd * C57BL/6NJ * FVB	abnormal locomotor behavior	J:346983
	abnormal spike wave discharge	J:346983
	normal behavior/neurological phenotype	J:346983
	decreased body size	J:346983
	decreased body weight	J:346983
	decreased vocalization	J:346983
	normal embryo phenotype	J:346983
	impaired righting response	J:346983
Gnb1^em1Dgold/Gnb1^em1Dgold C57BL/6NJ-Gnb1^em1Dgold	prenatal lethality, complete penetrance	J:346983
Gnb1^em2Dgold/Gnb1⁺ C57BL/6NJ-Gnb1^em2Dgold	normal behavior/neurological phenotype	J:346983
	normal embryo phenotype	J:346983
	normal mortality/aging	J:346983
Gnb1^em2Dgold/Gnb1^em2Dgold C57BL/6NJ-Gnb1^em2Dgold	prenatal lethality, complete penetrance	J:346983
Gnb1^{Gt(prvSStrap)4B8Yiw}/Gnb1^{Gt(prvSStrap)4B8Yiw} involves: 129P2/OlaHsd * C57BL/6J	abnormal brain morphology	J:157907
	abnormal cortical ventricular zone morphology	J:157907
	abnormal embryonic neuroepithelium morphology	J:157907
	abnormal neural plate morphology	J:157907
	abnormal neuron differentiation	J:157907
	abnormal neuronal precursor proliferation	J:157907
	abnormal suckling behavior	J:157907
	decreased brain size	J:157907
	decreased cell proliferation	J:157907
	exencephaly	J:157907
	lethality throughout fetal growth and development, incomplete penetrance	J:157907
	perinatal lethality, incomplete penetrance	J:157907
	respiratory failure	J:157907
	thin cerebral cortex	J:157907

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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