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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp2
low density lipoprotein receptor-related protein 2
MGI:95794
114 phenotypes from 6 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxg1tm1(cre)Skm/Foxg1+
Lrp2tm1Tew/Lrp2tm1Tew
involves: 129P2/OlaHsd 		abnormal dendrite morphology J:238249
abnormal eye morphology J:238249
abnormal intraocular pressure J:238249
abnormal lens morphology J:238249
abnormal optic nerve morphology J:238249
abnormal placement of pupils J:238249
abnormal posterior eye segment morphology J:238249
abnormal retina bipolar cell morphology J:238249
abnormal retina pigment epithelium morphology J:238249
abnormal retina pigmentation J:238249
abnormal sclera morphology J:238249
absent corpus callosum J:238249
decreased cell proliferation J:238249
decreased retina ganglion cell number J:238249
decreased total retina thickness J:238249
high myopia J:238249
increased retina apoptosis J:238249
macrophthalmia J:238249
ocular hypotelorism J:238249
sclera thinning J:238249
thin retina inner nuclear layer J:238249
thin retina inner plexiform layer J:238249
thin retina outer nuclear layer J:238249
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Lrp2tm1Tew/Lrp2tm1Tew
involves: C57BL/6J * CBA/J 		normal vision/eye phenotype J:238249
Lrp227SH/Lrp227SH
involves: A/J * C57BL/6N 		abnormal brain morphology J:186668
abnormal cerebellum fissure morphology J:186668
abnormal eye morphology J:186668
abnormal forebrain morphology J:186668
abnormal lateral ventricle morphology J:186668
abnormal olfactory bulb morphology J:186668
absent nasal septum J:186668
anophthalmia J:186668
cleft palate J:186668
holoprosencephaly J:186668
round forehead J:186668
small olfactory bulb J:186668
Lrp2b2b1625.2Clo/Lrp2b2b1625.2Clo
C57BL/6J-Lrp2b2b1625.2Clo 		omphalocele J:175213
persistent truncus arteriosus type i J:175213
vascular ring J:175213
Lrp2b2b2671Clo/Lrp2b2b2671Clo
C57BL/6J-Lrp2b2b2671Clo 		abnormal aortic arch morphology J:175213
abnormal myocardium compact layer morphology J:175213
anophthalmia J:175213
heart left ventricle hypertrophy J:175213
heart right ventricle hypertrophy J:175213
hydronephrosis J:175213
kidney cyst J:175213
kinked tail J:175213
micrognathia J:175213
microphthalmia J:175213
muscular ventricular septal defect J:175213
perimembraneous ventricular septal defect J:175213
persistent truncus arteriosus J:175213
right aortic arch J:175213
short snout J:175213
thymus hypoplasia J:175213
umbilical hernia J:175213
ventricular septal defect J:175213
Lrp2m267Asp/Lrp2m267Asp
involves: C57BL/6J * FVB/N 		abnormal circulating mineral level J:166387
abnormal selenium level J:166387
decreased glutathione peroxidase activity J:166387
exencephaly J:166387
impaired coordination J:166387
increased urine protein level J:166387
increased urine selenium level J:166387
Lrp2m267Asp/Lrp2m267Asp
Tg(Rr291-lacZ)#Mekk/0
involves: C57BL/6J * FVB/N 		abnormal cerebral cortex morphology J:136795
abnormal diencephalon morphology J:136795
abnormal olfactory bulb morphology J:136795
choroid plexus hyperplasia J:136795
Lrp2tm1Her/Lrp2+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal ear physiology J:134797
impaired hearing J:134797
increased or absent threshold for auditory brainstem response J:134797
Lrp2tm1Her/Lrp2tm1Her
either: (involves: 129S7/SvEvBrd * CD-1) or (involves: 129/SvEmcTer * 129S7/SvEvBrd * C57BL/6N) 		abnormal response/metabolism to endogenous compounds J:115189
abnormal testis development J:115189
abnormal testis morphology J:115189
dilated uterus J:115189
increased circulating dihydrotestosterone level J:115189
increased circulating testosterone level J:115189
unilateral cryptorchism J:115189
vaginal septum J:115189
Lrp2tm1Her/Lrp2tm1Her
involves: 129S7/SvEvBrd 		abnormal choroid plexus morphology J:34835
abnormal embryonic neuroepithelium morphology J:34835
abnormal forebrain development J:34835
abnormal proximal convoluted tubule morphology J:34835, J:108230
abnormal respiratory system physiology J:34835
abnormal telencephalon morphology J:34835
abnormal urine homeostasis J:108230
abnormal viscerocranium morphology J:34835
absent corpus callosum J:34835
absent olfactory bulb J:34835
anophthalmia J:34835
atelectasis J:34835
cyanosis J:34835
decreased embryo size J:34835
delayed neural tube closure J:34835
emphysema J:34835
exencephaly J:34835
flat forehead J:34835
holoprosencephaly J:34835
increased apoptosis J:34835
increased urine microglobulin level J:108230
increased urine protein level J:108230, J:184259
microphthalmia J:34835
overexpanded pulmonary alveolus J:34835
perinatal lethality, complete penetrance J:34835
respiratory failure J:34835
short snout J:34835
small embryonic telencephalon J:34835
Lrp2tm1Her/Lrp2tm1Her
involves: 129S7/SvEvBrd * C57BL/6 		abnormal hearing physiology J:134797
abnormal strial marginal cell morphology J:134797
impaired hearing J:134797
increased or absent threshold for auditory brainstem response J:134797
increased susceptibility to age-related hearing loss J:134797
perinatal lethality, incomplete penetrance J:134797
Lrp2tm1Her/Lrp2tm1Her
involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ 		abnormal selenium level J:211934
normal behavior/neurological phenotype J:211934
decreased glutathione peroxidase activity J:211934
normal growth/size/body region phenotype J:211934
increased urine selenium level J:211934
Lrp2tm1Tew/Lrp2tm1Tew
Not Specified 		decreased bone mineral content J:81496
normal homeostasis/metabolism phenotype J:81496
normal nervous system phenotype J:81496
Lrp2tm1Tew/Lrp2tm1Tew
Meox2tm1(cre)Sor/Meox2+
involves: 129S4/SvJaeSor 		abnormal renal reabsorption J:164025
Lrp2tm1Tew/Lrp2tm1Tew
Tg(APOE-cre)VITew/0
Not Specified 		abnormal bone mineralization J:81496
abnormal bone remodeling J:81496
abnormal urine homeostasis J:81496
abnormal vitamin D level J:81496
decreased bone mineral content J:81496
decreased circulating calcium level J:81496
increased bone resorption J:81496
increased circulating parathyroid hormone level J:81496
increased urine protein level J:81496
osteomalacia J:81496
Lrp2tm1Tew/Lrp2tm1Tew
Tg(GFAP-cre)25Mes/0
involves: FVB/N 		normal vision/eye phenotype J:238249
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory