Grb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grb2
growth factor receptor bound protein 2
MGI:95805

44 phenotypes from 6 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grb2^tm1.1Hua/Grb2^tm1.1Hua Tg(Lck-cre)1Jtak/0 involves: 129 * C57BL/6	abnormal T cell differentiation	J:161294
	decreased CD4-positive, alpha-beta T cell number	J:161294
	decreased CD8-positive, alpha-beta T cell number	J:161294
	decreased double-positive T cell number	J:161294
	decreased thymocyte number	J:161294
Grb2^{tm1a(EUCOMM)Wtsi}/Grb2^{tm1a(EUCOMM)Wtsi} B6Brd;B6Dnk;B6N-Tyr^c-Brd Grb2^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Grb2^tm1Lnit/Grb2^tm1Lnit Cd79a^tm1(cre)Reth/Cd79a⁺ involves: BALB/c * BALB/cJ	abnormal B cell differentiation	J:171222
	abnormal B cell physiology	J:171222
	abnormal memory B cell physiology	J:171222
	decreased B cell number	J:171222
	decreased follicular B cell number	J:171222
	decreased IgG3 level	J:171222
	decreased IgG level	J:171222
	decreased mature B cell number	J:171222
	decreased spleen germinal center number	J:171222
	decreased spleen germinal center size	J:171222
	decreased transitional stage T1 B cell number	J:171222
	decreased transitional stage T2 B cell number	J:171222
	increased B cell apoptosis	J:171222
	increased B cell proliferation	J:171222
	increased IgM level	J:171222
	increased plasma cell number	J:171222
Grb2^tm1Paw/Grb2⁺ involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:51424
Grb2^tm1Paw/Grb2⁺ involves: 129S1/Sv * 129X1/SvJ * BALB/c	decreased susceptibility to Retroviridae infection	J:122429
Grb2^tm1Paw/Grb2^tm1Paw involves: 129S1/Sv * 129X1/SvJ	abnormal endoderm development	J:51424
	absent inner cell mass proliferation	J:51424
	embryonic lethality between implantation and somite formation, complete penetrance	J:51424
Grb2^tm1Paw/Grb2^tm2Paw involves: 129S1/Sv * 129X1/SvJ	abnormal facial nerve morphology	J:69138
	abnormal heart development	J:69138
	abnormal otic vesicle development	J:69138
	abnormal vagus nerve morphology	J:69138
	absent second pharyngeal arch	J:69138
	decreased placental labyrinth size	J:69138
	embryonic lethality during organogenesis, complete penetrance	J:69138
	failure of chorioallantoic fusion	J:69138
Grb2^tm1Paw/Grb2^tm3.1Paw Tg(Nphs2-cre)1Seq/0 involves: 129S1/Sv * 129X1/SvJ	normal renal/urinary system phenotype	J:195444
Grb2^tm2Paw/Grb2^tm2Paw Not Specified	abnormal mandible morphology	J:69138
	absent gastric milk in neonates	J:69138
	cleft secondary palate	J:69138
	decreased body length	J:69138
	decreased placental labyrinth size	J:69138
	edema	J:69138
	hemorrhage	J:69138
	neonatal lethality, complete penetrance	J:69138
	palatal shelves fail to meet at midline	J:69138
Grb2^tm3.1Paw/Grb2^tm3.1Paw Tg(Nphs1-cre)2Seq/0 involves: 129S1/Sv * 129X1/SvJ	normal renal/urinary system phenotype	J:195444
Grb2^tm3.1Paw/Grb2^tm3.1Paw Tg(Nphs2-cre)1Seq/0 involves: 129S1/Sv * 129X1/SvJ	normal renal/urinary system phenotype	J:195444

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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