Tle5 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tle5
TLE family member 5, transcriptional modulator
MGI:95806

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(CAG-Aes,-ALPP)1Lbe/0 Tg(CAG-Tle1,-ALPP)1Lbe/0 involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal tumor susceptibility	J:106684
	decreased lung tumor incidence	J:106684
Tg(RP23-352G18)1Coppa/0 C57BL/6-Tg(RP23-352G18)1Coppa	decreased circulating glucose level	J:229077
	decreased susceptibility to diet-induced non-insulin dependent diabetes	J:229077
	decreased susceptibility to diet-induced obesity	J:229077
	improved glucose tolerance	J:229077
	increased insulin sensitivity	J:229077
Tle5^tm1.1Mmt/Tle5^tm1.1Mmt Apc^tm1Mmt/Apc⁺ Tg(Vil1-cre/ERT2)23Syr/0 involves: 129S2/SvPas * C57BL/6 * DBA * SJL	increased colon adenocarcinoma incidence	J:168065
	increased metastatic potential	J:168065
	increased small intestine adenocarcinoma incidence	J:168065
Tle5^tm1Grid/Tle5^tm1Grid Notch1^tm1Grid/Notch1⁺ involves: 129S1/Sv * C57BL/6J	postnatal growth retardation	J:29516
Tle5^tm1Grid/Tle5^tm1Grid Runx2^tm1Mjo/Runx2⁺ involves: 129S1/Sv * C57BL/6	abnormal fontanelle morphology	J:92187
	abnormal long bone hypertrophic chondrocyte zone	J:92187
	abnormal skeleton development	J:92187
	clavicle hypoplasia	J:92187
	decreased body weight	J:92187
	decreased bone mineral density	J:92187
	decreased long bone epiphyseal plate size	J:92187
	decreased width of hypertrophic chondrocyte zone	J:92187
	disproportionate dwarf	J:92187
	female infertility	J:92187
	male infertility	J:92187
	postnatal growth retardation	J:92187

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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