Gria1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
MGI:95808

57 phenotypes from 12 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gria1^em1(IMPC)H/Gria1^em1(IMPC)H C57BL/6N-Gria1^em1(IMPC)H/H	abnormal freezing behavior	J:211773
	abnormal gait	J:211773
	abnormal locomotor behavior	J:211773
	decreased exploration in new environment	J:211773
	decreased freezing behavior	J:211773
	decreased prepulse inhibition	J:211773
	hyperactivity	J:211773
	hypoalgesia	J:211773
	impaired contextual conditioning behavior	J:211773
	impaired cued conditioning behavior	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating iron level	J:211773
	increased circulating serum albumin level	J:211773
	increased mechanical nociceptive threshold	J:211773
Gria1^{em1(IMPC)Hmgu}/Gria1^{em1(IMPC)Hmgu} C57BL/6N-Gria1^{em1(IMPC)Hmgu}/Ieg	decreased bone mineral content	J:211773
	decreased exploration in new environment	J:211773
	decreased prepulse inhibition	J:211773
	decreased startle reflex	J:211773
	decreased vertical activity	J:211773
	hyperactivity	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased circulating amylase level	J:211773
Gria1^tm1Erk/Gria1^tm1Erk involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal locomotor behavior	J:101930
	abnormal response to new environment	J:75498
	abnormal sexual interaction	J:101930
	abnormal social investigation	J:101930
	normal behavior/neurological phenotype	J:75498
	decreased aggression towards male mice	J:101930
	normal homeostasis/metabolism phenotype	J:75498, J:101930
	hyperactivity	J:75498
	increased vertical activity	J:101930
Gria1^tm1Lex/Gria1^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	decreased glycosylated hemoglobin level	J:82809
	increased blood urea nitrogen level	J:82809
	increased locomotor activity	J:82809
Gria1^tm1Rlh/Gria1^tm1Rlh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal associative learning	J:135196
	abnormal long-term spatial reference memory	J:82443
	absent long-term depression	J:82443
	reduced long-term potentiation	J:82443
Gria1^tm1Rsp/Gria1^tm1Rsp B6.129-Gria1^tm1Rsp	abnormal nociception after inflammation	J:96597
	abnormal spinal cord morphology	J:96597
	decreased chemical nociceptive threshold	J:96597
	impaired synaptic plasticity	J:96597
	increased anxiety-related response	J:167264
	reduced AMPA-mediated synaptic currents	J:96597
Gria1^tm1Rsp/Gria1^tm1Rsp involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal behavioral response to xenobiotic	J:75498
	abnormal locomotor behavior	J:75498, J:101930
	abnormal response to new environment	J:75498
	abnormal serotonin level	J:101930
	abnormal sexual interaction	J:101930
	abnormal social investigation	J:101930
	normal behavior/neurological phenotype	J:55695
	decreased aggression towards male mice	J:101930
	decreased anxiety-related response	J:101930
	decreased behavioral withdrawal response	J:75498
	decreased body size	J:55695
	normal homeostasis/metabolism phenotype	J:75498, J:101930
	hyperactivity	J:75498
	increased exploration in new environment	J:101930
	increased vertical activity	J:101930
	normal nervous system phenotype	J:55695
	reduced AMPA-mediated synaptic currents	J:55695
	reduced long-term potentiation	J:55695
Gria1^tm1Rsp/Gria1^tm1Rsp involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal emotion/affect behavior	J:167264
Gria1^tm1Rsp/Gria1^tm1Rsp involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J	abnormal emotion/affect behavior	J:167264
	normal homeostasis/metabolism phenotype	J:167264
	hyperactivity	J:167264
	increased exploration in new environment	J:167264
	induced hyperactivity	J:167264
Gria1^tm2Rlh/Gria1^tm2Rlh B6.Cg-Gria1^tm2Rlh	abnormal dendrite morphology	J:141127
Gria1^tm2Rlh/Gria1^tm2Rlh involves: 129 * C57BL/6	normal nervous system phenotype	J:101578
Gria1^tm2Rsp/Gria1^tm2Rsp involves: 129S1/Sv * 129X1/SvJ	abnormal miniature excitatory postsynaptic currents	J:197912
Gria1^tm2Rsp/Gria1^tm2Rsp Tg(Pvalb-cre)1Mony/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal excitatory postsynaptic potential	J:136763
	abnormal nervous system electrophysiology	J:136763
	abnormal spatial working memory	J:136763
	normal behavior/neurological phenotype	J:136763
	impaired ability to fire action potentials	J:136763
	reduced AMPA-mediated synaptic currents	J:136763
Gria1^tm2Rsp/Gria1^tm2Rsp Tg(Slc6a3-icre)9075Gsc/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal glutamate-mediated receptor currents	J:139693
	enhanced conditioned place preference behavior	J:139693
Gria1^tm4Rlh/Gria1^tm4Rlh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	absent long-term depression	J:126784
Gria1^tm5Rlh/Gria1^tm5Rlh involves: 129 * C57BL/6	abnormal associative learning	J:135196
Gria1^tm6Rlh/Gria1^tm6Rlh involves: 129 * C57BL/6	no abnormal phenotype detected	J:135196
Gria1^tm7Rlh/Gria1^tm7Rlh involves: 129S6/SvEvTac * C57BL/6	abnormal long-term potentiation	J:172128
Gria1^tm7Rlh/Gria1^tm7Rlh involves: 129S6/SvEvTac * C57BL/6	normal nervous system phenotype	J:172128

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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