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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
MGI:95809
76 phenotypes from 15 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gria2em1(IMPC)H/Gria2+
C57BL/6NTac-Gria2em1(IMPC)H/H 		decreased grip strength J:211773
increased circulating alanine transaminase level J:211773
prolonged QRS complex duration J:211773
Gria2em1(IMPC)H/Gria2em1(IMPC)H
C57BL/6NTac-Gria2em1(IMPC)H/H 		preweaning lethality, complete penetrance J:211773
Gria2tm1.1Bvis/Gria2tm1.1Bvis
Tg(Camk2a-cre)T29-1Stl/0
129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl 		abnormal learning/memory/conditioning J:223717
abnormal long-term spatial reference memory J:223717
enhanced long-term potentiation J:223717
impaired contextual conditioning behavior J:223717
impaired spatial learning J:223717
Gria2tm1.1Phs/Gria2tm1.1Phs
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 		normal nervous system phenotype J:50929
Gria2tm1Lex/Gria2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6 		abnormal circadian sleep/wake cycle J:82809
decreased exploration in new environment J:82809
decreased grip strength J:82809
decreased locomotor activity J:82809
Gria2tm1Phs/Gria2tm1Phs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal nervous system electrophysiology J:50929
normal nervous system phenotype J:50929
Gria2tm1Rlh/Gria2tm1Rlh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		impaired synaptic plasticity J:99813
Gria2tm1Rod/Gria2+
B6.129-Gria2tm1Rod/J 		abnormal AMPA-mediated synaptic currents J:104951
increased susceptibility to neuronal excitotoxicity J:104951
Gria2tm1Rod/Gria2tm1Rod
B6.129-Gria2tm1Rod/J 		abnormal AMPA-mediated synaptic currents J:104951
abnormal limb posture J:104951
abnormal response to novel object J:104951
decreased grip strength J:104951
decreased locomotor activity J:104951
impaired coordination J:104951
increased susceptibility to neuronal excitotoxicity J:104951
Gria2tm1Rod/Gria2tm1Rod
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal reflex J:64275
abnormal response to novel object J:64275
decreased body size J:64275
decreased body weight J:64275
decreased exploration in new environment J:64275
decreased grooming behavior J:64275
enhanced long-term potentiation J:64275
impaired coordination J:64275
postnatal lethality, incomplete penetrance J:64275
Gria2tm1Rsp/Gria2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal AMPA-mediated synaptic currents J:30145
abnormal cell physiology J:30145
abnormal emotion/affect behavior J:30145
abnormal grooming behavior J:30145
hippocampal neuron degeneration J:30145
increased locomotor activity J:30145
jumpy J:30145
paraparesis J:30145
postnatal growth retardation J:30145
postnatal lethality, complete penetrance J:30145
seizures J:30145
tonic-clonic seizures J:30145
Gria2tm1Sans/Gria2tm1Sans
involves: 129S/SvEv 		normal hearing/vestibular/ear phenotype J:98870
Gria2tm2.1Rsp/Gria2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal AMPA-mediated synaptic currents J:51845
abnormal hippocampus CA3 region morphology J:51845
abnormal motor capabilities/coordination/movement J:51845
decreased body weight J:51845
postnatal lethality, complete penetrance J:51845
seizures J:51845
Gria2tm2Rlh/Gria2tm2Rlh
involves: 129S1/Sv * 129X1/SvJ 		absent long-term depression J:107573
Gria2tm2Rsp/Gria2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal AMPA-mediated synaptic currents J:51845
premature death J:51845
Gria2tm2Rsp/Gria2+
Tg(Camk2a-cre)1Gsc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal brain interneuron morphology J:111689
abnormal CNS glial cell morphology J:111689
abnormal neuron differentiation J:111689
loss of hippocampal neurons J:111689
seizures J:111689
Gria2tm2Rsp/Gria2+
Tg(Camk2a-cre)1Gsc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * NMRI 		abnormal olfactory discrimination memory J:103689
Gria2tm2Rsp/Gria2+
Tg(Gria2*586N)238.2Rsp/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal AMPA-mediated synaptic currents J:51845
abnormal hippocampus CA3 region morphology J:51845
abnormal motor capabilities/coordination/movement J:51845
premature death J:51845
seizures J:51845
Gria2tm2Rsp/Gria2tm2Rsp
involves: 129S1/Sv * 129X1/SvJ 		abnormal AMPA-mediated synaptic currents J:51845
abnormal excitatory postsynaptic potential J:51845
abnormal hippocampus CA3 region morphology J:51845
decreased body weight J:51845
lethargy J:51845
postnatal growth retardation J:51845
postnatal lethality, complete penetrance J:51845
Gria2tm3.1Rsp/Gria2tm3.1Rsp
involves: CD-1 		abnormal nociception after inflammation J:96597
abnormal spinal cord morphology J:96597
abnormal touch/ nociception J:96597
decreased chemical nociceptive threshold J:96597
enhanced AMPA-mediated synaptic currents J:96597
hyperalgesia J:96597
impaired synaptic plasticity J:96597
Gria2tm3Rsp/Gria2tm3Rsp
Tg(Camk2a-cre)1Gsc/0
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N 		abnormal AMPA-mediated synaptic currents J:111689
abnormal brain interneuron morphology J:111689
abnormal excitatory postsynaptic currents J:111689
abnormal excitatory postsynaptic potential J:111689
abnormal neuron differentiation J:111689
abnormal paired-pulse facilitation J:111689
abnormal spatial reference memory J:111689
abnormal spatial working memory J:111689
normal behavior/neurological phenotype J:111689
loss of hippocampal neurons J:111689
Gria2tm3Rsp/Gria2tm3Rsp
Tg(Camk2a-cre)1Gsc/0
involves: C57BL/6 * FVB/N 		abnormal learning/memory/conditioning J:103689
abnormal olfactory discrimination memory J:103689
abnormal spatial learning J:103689
impaired coordination J:103689
increased anxiety-related response J:103689
increased exploration in new environment J:103689
Gria2tm3Rsp/Gria2tm3Rsp
Tg(Gnrh1-cre)1Rsp/0
involves: C57BL/6 		abnormal AMPA-mediated synaptic currents J:103818
abnormal pup retrieval J:103818
abnormal sexual interaction J:103818
decreased aggression towards male mice J:103818
decreased mounting behavior J:103818
increased anxiety-related response J:103818
reduced male mating frequency J:103818
normal reproductive system phenotype J:103818
Gria2tm3Rsp/Gria2tm3Rsp
Tg(Slc6a3-icre)9075Gsc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal glutamate-mediated receptor currents J:139693
Tg(Gria2*586N)238.2Rsp/0
Not Specified 		abnormal AMPA-mediated synaptic currents J:51845
abnormal amygdala morphology J:97818
abnormal reflex J:97818
abnormal spinal cord ventral horn morphology J:97818
abnormal ventromedial hypothalamic nucleus morphology J:97818
decreased body weight J:97818
decreased locomotor activity J:97818
decreased spinal cord ventral horn cell number J:97818
gliosis J:97818
increased anxiety-related response J:97818
motor neuron degeneration J:51845, J:97818
short stride length J:97818
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory