Gria2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gria2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
MGI:95809

20 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adarb1^tm1.1Skwa/Adarb1^tm1.1Skwa Gria2^tm1.1Phs/Gria2^tm1.1Phs Tg(SLC18A3-cre)KMisa/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal behavior/neurological phenotype	J:164294
	normal nervous system phenotype	J:164294
Adarb1^tm1Phs/Adarb1^tm1Phs Gria2^tm1.1Phs/Gria2⁺ involves: 129S1/Sv * 129X1/SvJ	postnatal lethality, incomplete penetrance	J:63273
Adarb1^tm1Phs/Adarb1^tm1Phs Gria2^tm1.1Phs/Gria2^tm1.1Phs involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:63273
Gria2^tm1Rod/Gria2⁺ Tg(SOD1G93A)1Gur/0 B6.Cg-Gria2^tm1Rod Tg(SOD1G93A)1Gur	decreased motor neuron number	J:104951
Gria2^tm1Rod/Gria2^tm1Rod Gria3^tm1Zpj/Y involves: 129/Sv * C57BL/6	abnormal excitatory postsynaptic potential	J:84336
	abnormal long-term depression	J:84336
	abnormal motor capabilities/coordination/movement	J:84336
	abnormal synaptic plasticity	J:84336
	decreased body size	J:84336
	decreased locomotor activity	J:84336
	enhanced long-term potentiation	J:84336
	normal nervous system phenotype	J:84336
	postnatal lethality, incomplete penetrance	J:84336
	tremors	J:84336
Gria2^tm1Rod/Gria2^tm1Rod Tg(SOD1G93A)1Gur/0 B6.Cg-Gria2^tm1Rod Tg(SOD1G93A)1Gur	abnormal AMPA-mediated synaptic currents	J:104951
	decreased grip strength	J:104951
	decreased motor neuron number	J:104951
	hindlimb paralysis	J:104951
	impaired coordination	J:104951
	premature death	J:104951
Tg(Gria2586N)238.2Rsp/0 Tg(SOD1G93A)1Gur/0 involves: C57BL/6Ico	impaired righting response	J:97818
	premature death	J:97818
	tremors	J:97818
	weight loss	J:97818

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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