Gria4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gria4
glutamate receptor, ionotropic, AMPA4 (alpha 4)
MGI:95811

31 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gja10^{tm2.1(cre)Kwi}/Gja10⁺ Gria4^tm1Mony/Gria4^tm1Mony involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal eye physiology	J:207456
	abnormal glutamate-mediated receptor currents	J:207456
Gria4^spkw1/Gria4⁺ involves: C3H/HeJ * C3HeB/FeJ	absence seizures	J:135814
Gria4^spkw1/Gria4^spkw1 C3Fe.C3-Gria4^spkw1	abnormal spike wave discharge	J:228536
Gria4^spkw1/Gria4^spkw1 C3H/HeJ	absence seizures	J:135814
Gria4^spkw1/Gria4^spkw1 involves: C3H/HeJ * C3HeB/FeJ	absence seizures	J:135814
Gria4^spkw1/Gria4^spkw1 involves: C3H/HeJ * C57BL/6J	absence seizures	J:98638
Gria4^spkw1/Gria4^tm1Dgen involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J	absence seizures	J:135814
Gria4^tm1.1Mony/Gria4^tm1.1Mony involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal action potential	J:136763
	abnormal AMPA-mediated synaptic currents	J:136763
	abnormal excitatory postsynaptic potential	J:136763
	abnormal inhibitory postsynaptic potential	J:136763
	abnormal nervous system electrophysiology	J:136763
	abnormal neuron physiology	J:136763
	abnormal object recognition memory	J:136763
	abnormal spatial working memory	J:136763
	decreased exploration in new environment	J:136763
	decreased vertical activity	J:136763
	impaired ability to fire action potentials	J:136763
Gria4^tm1Dgen/Gria4⁺ involves: 129P2/OlaHsd * C57BL/6J	absence seizures	J:135814
Gria4^tm1Dgen/Gria4^tm1Dgen involves: 129P2/OlaHsd * C57BL/6	abnormal seizure response to pharmacological agent	J:101679
	increased locomotor activity	J:101679
	increased thermal nociceptive threshold	J:101679
Gria4^tm1Dgen/Gria4^tm1Dgen involves: 129P2/OlaHsd * C57BL/6J	absence seizures	J:135814
Gria4^tm1Rlh/Gria4^tm1Rlh involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal nervous system phenotype	J:99813
Gria4^tm1Yfkk/Gria4^tm1Yfkk B6.129S-Gria4^tm1Yfkk	abnormal social investigation	J:178206
	abnormal spatial reference memory	J:178206
	normal behavior/neurological phenotype	J:178206
	decreased body weight	J:178206
	decreased grip strength	J:178206
	decreased prepulse inhibition	J:178206
	decreased startle reflex	J:178206
	decreased vertical activity	J:178206
	enhanced spatial working memory	J:178206
	increased anxiety-related response	J:178206
	increased physiological sensitivity to xenobiotic	J:178206
	increased vertical activity	J:178206
	induced hyperactivity	J:178206
	normal nervous system phenotype	J:178206

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