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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
MGI:95819
119 phenotypes from 24 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Emx1tm1(cre)Ito/Emx1+
Grin1tm1Stl/Grin1tm2Stl
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6 		abnormal postnatal growth J:64064
abnormal primary somatosensory cortex morphology J:80900
abnormal somatosensory cortex morphology J:64064
absent barrels in primary somatosensory cortex J:64064, J:80900
decreased body weight J:64064
reduced NMDA receptor mediated synaptic activity in barrel cortex J:64064
Grik4tm1(cre)Mim/Grik4+
Grin1tm1Mim/Grin1tm1Mim
involves: C57BL/6N 		abnormal brain wave pattern J:144994
abnormal nervous system electrophysiology J:144994
abnormal postural reflex J:144994
increased susceptibility to pharmacologically induced seizures J:144994
normal nervous system phenotype J:144994
tonic-clonic seizures J:144994
Grin1Rgsc174/Grin1+
(D2.B6-Grin1Rgsc174 x C57BL/6J)F1 		normal behavior/neurological phenotype J:160947
Grin1Rgsc174/Grin1+
C57BL/6J-Grin1Rgsc174 		abnormal behavioral response to xenobiotic J:160947
abnormal neuron physiology J:160947
abnormal physiological response to xenobiotic J:160947
abnormal social investigation J:160947
normal behavior/neurological phenotype J:160947
hyperactivity J:160947
increased exploration in new environment J:160947
Grin1Rgsc174/Grin1+
involves: C57BL/6JJcl * DBA/2JJcl 		hyperactivity J:133634
impaired passive avoidance behavior J:133634
Grin1Rgsc174/Grin1Rgsc174
C57BL/6J-Grin1Rgsc174 		abnormal neuron physiology J:160947
perinatal lethality, incomplete penetrance J:160947
postnatal lethality, incomplete penetrance J:160947
Grin1tm1.1Ese/Grin1tm1.1Ese
involves: C57BL/6 		abnormal glutamate-mediated receptor currents J:153043
abnormal miniature excitatory postsynaptic currents J:153043
abnormal social investigation J:153043
decreased prepulse inhibition J:153043
decreased vertical activity J:153043
reduced AMPA-mediated synaptic currents J:153043
reduced long-term potentiation J:153043
Grin1tm1.1Phs/Grin1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal maternal grooming J:75497
abnormal maternal nurturing J:75497
abnormal nest building behavior J:75497
abnormal pup retrieval J:75497
abnormal social/conspecific interaction behavior J:75497
absent maternal crouching J:75497
hyperactivity J:75497
premature death J:75497
pup cannibalization J:75497
Grin1tm1.1Phs/Grin1tm1.1Phs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal breathing pattern J:75497
abnormal nervous system electrophysiology J:75497
abnormal NMDA-mediated synaptic currents J:75497
absent gastric milk in neonates J:75497
aphagia J:75497
cyanosis J:75497
neonatal lethality, complete penetrance J:75497
normal nervous system phenotype J:75497
respiratory distress J:75497
Grin1tm1.1Slab/Grin1+
involves: 129P2/OlaHsd * C57BL/6J 		hyperactivity J:82670
neonatal lethality, complete penetrance J:82670
respiratory distress J:82670
Grin1tm1a(EUCOMM)Wtsi/Grin1+
C57BL/6N-Grin1tm1a(EUCOMM)Wtsi/Wtsi 		thrombocytopenia J:175295
Grin1tm1Bhk/Grin1tm1Bhk
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2 		abnormal auditory brainstem response J:203256
abnormal hearing electrophysiology J:203256
abnormal social investigation J:203256
abnormal spatial working memory J:203256
decreased prepulse inhibition J:203256
decreased vocalization J:203256
increased grooming behavior J:203256
increased locomotor activity J:203256
increased startle reflex J:203256
limb grasping J:203256
reduced male mating frequency J:203256
Grin1tm1Bhk/Grin1tm1Bhk
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal huddling behavior J:57125
abnormal motor capabilities/coordination/movement J:57125
abnormal social investigation J:57125
abnormal social/conspecific interaction behavior J:57125
decreased aggression towards mice J:91878
decreased body weight J:57125
decreased prepulse inhibition J:91878
increased locomotor activity J:57125
increased startle reflex J:91878
reduced male fertility J:57125
reduced male mating frequency J:57125
social withdrawal J:57125
stereotypic behavior J:57125
Grin1tm1Blt/Grin1tm1Blt
involves: 129P2/OlaHsd * C57BL/6 		abnormal locomotor behavior J:62289
abnormal nervous system physiology J:62289
abnormal spatial learning J:62289
decreased susceptibility to pharmacologically induced seizures J:62289
impaired coordination J:62289
increased startle reflex J:62289
reduced long-term potentiation J:62289
Grin1tm1c(EUCOMM)Wtsi/Grin1tm1c(EUCOMM)Wtsi
Tg(Slc6a4-cre)ET127Gsat/0
involves: C57BL/6 * C57BL/6N * FVB/N * SJL 		abnormal miniature excitatory postsynaptic currents J:193625
abnormal NMDA-mediated synaptic currents J:193625
decreased excitatory postsynaptic current amplitude J:193625
reduced NMDA-mediated synaptic currents J:193625
Grin1tm1c(EUCOMM)Wtsi/Grin1tm2.1Stl
Tg(Slc6a4-cre)ET127Gsat/0
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL 		abnormal miniature excitatory postsynaptic currents J:193625
abnormal NMDA-mediated synaptic currents J:193625
decreased excitatory postsynaptic current amplitude J:193625
reduced NMDA-mediated synaptic currents J:193625
Grin1tm1Cur/Grin1tm1.1Phs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal breathing pattern J:75497
abnormal pulmonary respiratory rate J:75497
absence of NMDA-mediated synaptic currents J:75497
absent gastric milk in neonates J:75497
aphagia J:75497
cyanosis J:75497
neonatal lethality, complete penetrance J:75497
respiratory distress J:75497
Grin1tm1Cur/Grin1tm1Cur
involves: 129S1/Sv * C57BL/6 		abnormal glutamate-mediated receptor currents J:66345
absence of NMDA-mediated synaptic currents J:66345
absent gastric milk in neonates J:66345
atelectasis J:66345
normal cardiovascular system phenotype J:66345
cyanosis J:66345
lung hemorrhage J:66345
normal nervous system phenotype J:66345
overexpanded pulmonary alveolus J:66345
perinatal lethality, complete penetrance J:66345
Grin1tm1Cur/Grin1tm2.1Phs
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		aphagia J:75497
neonatal lethality, complete penetrance J:75497
respiratory distress J:75497
Grin1tm1Jjwd/Grin1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal anxiety-related response J:209690
abnormal behavioral response to alcohol J:209690
abnormal conditioned taste aversion behavior J:209690
abnormal NMDA-mediated synaptic currents J:209690
decreased alcohol consumption J:209690
increased alcohol consumption J:209690
normal taste/olfaction phenotype J:209690
Grin1tm1Jjwd/Grin1tm1Jjwd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal NMDA-mediated synaptic currents J:209690
postnatal lethality, complete penetrance J:209690
Grin1tm1Nak/Grin1tm1Nak
involves: 129S/Sv * C57BL/6 * DBA/2 		abnormal glutamate-mediated receptor currents J:38582
abnormal suckling behavior J:38582
absent gastric milk in neonates J:38582
cyanosis J:38582
decreased susceptibility to neuronal excitotoxicity J:38582
neonatal lethality, complete penetrance J:38582
Grin1tm1Rpa/Grin1tm1.1Rpa
Not Specified 		abnormal excitatory postsynaptic currents J:145468
abnormal miniature excitatory postsynaptic currents J:145468
impaired conditioned place preference behavior J:145468
Grin1tm1Rpa/Grin1tm1.1Rpa
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv 		abnormal behavioral response to addictive substance J:145468
abnormal excitatory postsynaptic currents J:145468
abnormal miniature excitatory postsynaptic currents J:145468
impaired conditioned place preference behavior J:145468
increased miniature excitatory postsynaptic current amplitude J:145468
increased miniature excitatory postsynaptic current frequency J:145468
reduced long-term potentiation J:145468
Grin1tm1Rsp/Grin1tm1Rsp
Tg(Camk2a-tTA)1Mmay/?
Tg(tetO-cre)LC1Bjd/?
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 		abnormal long-term potentiation J:119834
abnormal spatial working memory J:119834
Grin1tm1Rsp/Grin1tm1Rsp
Tg(Gnrh1-cre)1Rsp/0
involves: C57BL/6 		absence of NMDA-mediated synaptic currents J:103818
normal reproductive system phenotype J:103818
Grin1tm1Rsp/Grin1tm1Rsp
Tg(Slc6a3-icre)9075Gsc/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal glutamate-mediated receptor currents J:139693
abnormal NMDA-mediated synaptic currents J:139693
impaired behavioral response to cocaine J:139693
Grin1tm1Rsp/Grin1tm1Rsp
Tg(Slc6a3-icre)9075Gsc/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal AMPA-mediated synaptic currents J:139693
abnormal glutamate-mediated receptor currents J:139693
abnormal NMDA-mediated synaptic currents J:139693
impaired behavioral response to cocaine J:139693
Grin1tm1Slab/Grin1tm1Slab
involves: 129P2/OlaHsd * C57BL/6J 		neonatal lethality, complete penetrance J:82670
Grin1tm1Stl/Grin1tm1Stl
either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6) 		abnormal brainstem morphology J:17384
abnormal suckling behavior J:17384
absence of NMDA-mediated synaptic currents J:17384
apnea J:17384
ataxia J:17384
cyanosis J:17384
neonatal lethality, complete penetrance J:17384
Grin1tm1Yql/Grin1tm1Yql
Rgs9tm1.1(cre)Yql/Rgs9+
involves: 129/Sv * BALB/c * C57BL/6 		abnormal excitatory postsynaptic currents J:115299
abnormal medium spiny neuron morphology J:115299
abnormal motor learning J:115299
abnormal NMDA-mediated synaptic currents J:115299
absent long-term depression J:115299
reduced long-term potentiation J:115299
Grin1tm1Yql/Grin1tm1Yql
Tg(Ppp1r2-cre)4127Nkza/0
involves: C57BL/6N 		abnormal liquid preference J:156785
abnormal nervous system electrophysiology J:156785
abnormal nest building behavior J:156785
abnormal sexual interaction J:156785
abnormal social investigation J:156785
abnormal spatial working memory J:156785
normal behavior/neurological phenotype J:156785
decreased prepulse inhibition J:156785
normal growth/size/body region phenotype J:156785
normal hearing/vestibular/ear phenotype J:156785
normal homeostasis/metabolism phenotype J:156785
increased anxiety-related response J:156785
increased locomotor activity J:156785
increased thigmotaxis J:156785
normal vision/eye phenotype J:156785
Grin1tm2.1Phs/Grin1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal food intake J:75497
abnormal motor capabilities/coordination/movement J:75497
decreased locomotor activity J:75497
impaired righting response J:75497
postnatal growth retardation J:75497
postnatal lethality, complete penetrance J:75497
Grin1tm2Blt/Grin1tm2Blt
involves: 129P2/OlaHsd * C57BL/6 		abnormal nervous system physiology J:62289
absent suckling reflex J:62289
decreased body weight J:62289
postnatal growth retardation J:62289
postnatal lethality, complete penetrance J:62289
Grin1tm2Phs/Grin1tm2Phs
involves: 129S1/Sv * 129X1/SvJ 		aphagia J:75497
decreased respiration J:75497
neonatal lethality, complete penetrance J:75497
Grin1tm2Slab/Grin1tm1.1Slab
involves: 129P2/OlaHsd * C57BL/6J 		abnormal brainstem morphology J:82670
abnormal nervous system electrophysiology J:82670
abnormal trigeminal nerve morphology J:82670
cyanosis J:82670
neonatal lethality, complete penetrance J:82670
respiratory distress J:82670
Grin1tm2Stl/Grin1tm2Stl
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal contextual conditioning behavior J:60730
abnormal excitatory postsynaptic currents J:37457
abnormal object recognition memory J:60730
abnormal olfactory discrimination memory J:60730
abnormal spatial learning J:37457
absence of NMDA-mediated synaptic currents J:37457
impaired social transmission of food preference J:60730
reduced long-term potentiation J:37457
Grin1tm2Stl/Grin1tm2Stl
Tg(Grik4-cre)G32-4Stl/0
involves: C57BL/6 		abnormal NMDA-mediated synaptic currents J:77718
abnormal single cell response J:77718
abnormal spatial learning J:77718
reduced long-term potentiation J:77718
Grin1tm2Stl/Grin1tm2Stl
Tg(Pomc-cre)1Lowl/0
involves: 129S4/SvJae * C57BL/6 * FVB 		abnormal discrimination learning J:122763
normal behavior/neurological phenotype J:122763
impaired synaptic plasticity J:122763
normal nervous system phenotype J:122763
Grin1tm2Stl/Grin1tm2Stl
Tg(Ppp1r2-cre)4127Nkza/0
involves: 129S4/SvJae * C57BL/6N 		normal behavior/neurological phenotype J:156785
normal nervous system phenotype J:156785
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11/12/2024
MGI 6.24 		The Jackson Laboratory