Grin2a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
MGI:95820

23 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grin2a^tm1.1Jpleo/Grin2a^tm1.1Jpleo involves: 129S4/SvJae * C57BL/6 * FVB/N	abnormal spatial working memory	J:235504
	decreased anxiety-related response	J:235504
	decreased exploration in new environment	J:235504
	normal nervous system phenotype	J:235504
Grin2a^tm1.1Ppao/Grin2a^tm1.1Ppao involves: 129 * C57BL/6	abnormal excitatory postsynaptic currents	J:175900
	allodynia	J:175900
	normal behavior/neurological phenotype	J:175900
	decreased chemical nociceptive threshold	J:175900
	decreased chemically-elicited antinociception	J:175900
	decreased thermal nociceptive threshold	J:175900
Grin2a^tm1.1Tnkw/Grin2a^tm1.1Tnkw involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	abnormal depression-related behavior	J:155360
	abnormal excitatory postsynaptic currents	J:155360
	normal behavior/neurological phenotype	J:155360
	normal nervous system phenotype	J:155360
	reduced NMDA-mediated synaptic currents	J:155360
Grin2a^tm1Mim/Grin2a^tm1Mim B6.Cg-Grin2a^tm1Mim	increased startle reflex	J:89405
Grin2a^tm1Mim/Grin2a^tm1Mim involves: C57BL/6 * CBA	abnormal spatial learning	J:22295
	jumpy	J:22295
	reduced long-term potentiation	J:22295
	reduced NMDA-mediated synaptic currents	J:22295
Grin2a^tm1Nak/Grin2a^tm1Nak involves: 129S/SvEv	abnormal excitatory postsynaptic currents	J:66455
	abnormal miniature excitatory postsynaptic currents	J:66455
	normal behavior/neurological phenotype	J:66455
	decreased vertical activity	J:66455
	normal nervous system phenotype	J:66455
Grin2a^tm1Rsp/Grin2a^tm1Rsp involves: 129S1/Sv * 129X1/SvJ	decreased anxiety-related response	J:197485
	decreased kindling response	J:45446
	impaired contextual conditioning behavior	J:45446
	impaired coordination	J:45446
	normal nervous system phenotype	J:45446
	reduced long-term potentiation	J:45446, J:197485
Tg(Camk2a-Grin2a)1Jzt/? involves: C57BL/6	impaired cued conditioning behavior	J:223086
Tg(Camk2a-Grin2a)1Jzt/? involves: C57BL/6	impaired long-term object recognition memory	J:223086

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24