Grin2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
MGI:95821

59 phenotypes from 11 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Grin2b^em1Weya/Grin2b^em1Weya Not Specified	abnormal miniature excitatory postsynaptic currents	J:334279
	abnormal nervous system physiology	J:334279
	normal behavior/neurological phenotype	J:334279
	normal growth/size/body region phenotype	J:334279
	increased coping response	J:334279
	increased dendritic spine density	J:334279
	normal nervous system phenotype	J:334279
Grin2b^tm1.1Jlbr/Grin2b^tm1.1Jlbr Neurod6^tm1(cre)Kan/Neurod6⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal suckling behavior	J:178913
	increased locomotor activity	J:178913
	social withdrawal	J:178913
Grin2b^tm1.1Jlbr/Grin2b^tm1.1Jlbr Tg(Camk2a-cre)T29-1Stl/0 involves: 129S6/SvEvTac * BALB/c * C57BL/6	abnormal associative learning	J:159387
	abnormal excitatory postsynaptic currents	J:159387
	abnormal excitatory postsynaptic potential	J:159387
	abnormal learning/memory/conditioning	J:159387
	abnormal spatial learning	J:159387
	absent long-term depression	J:159387
	decreased dendritic spine density	J:159387
	decreased excitatory postsynaptic current amplitude	J:159387
	decreased physiological sensitivity to xenobiotic	J:159387
	impaired swimming	J:159387
	increased thigmotaxis	J:159387
	reduced long-term depression	J:159387
	reduced long-term potentiation	J:159387
	short excitatory postsynaptic current decay time	J:159387
Grin2b^tm1.1Jwhe/Grin2b^tm1.1Jwhe B6JBomTac.129P2-Grin2b^tm1.1Jwhe	abnormal temporal memory	J:181943
	normal behavior/neurological phenotype	J:181943
	normal nervous system phenotype	J:181943
	reduced long-term potentiation	J:181943
Grin2b^{tm1e.1(KOMP)Wtsi}/Grin2b⁺ C57BL/6N-Grin2b^{tm1e.1(KOMP)Wtsi}/Tcp	decreased locomotor activity	J:211773
	enlarged heart	J:211773
	increased mean platelet volume	J:211773
	increased startle reflex	J:211773
Grin2b^{tm1e.1(KOMP)Wtsi}/Grin2b^{tm1e.1(KOMP)Wtsi} C57BL/6N-Grin2b^{tm1e.1(KOMP)Wtsi}/Tcp	preweaning lethality, incomplete penetrance	J:211773
Grin2b^tm1Ksak/Grin2b^tm1Ksak Grik4^tm1(cre)Ksak/Grik4⁺ C57BL/6-Grin2b^tm1Ksak Grik4^tm1(cre)Ksak	abnormal dendrite morphology	J:152455
	abnormal synapse morphology	J:152455
	absence of NMDA-mediated synaptic currents	J:152455
	normal nervous system phenotype	J:152455
	reduced long-term potentiation	J:152455
Grin2b^tm1Mim/Grin2b⁺ B6.Cg-Grin2b^tm1Mim	increased prepulse inhibition	J:89405
Grin2b^tm1Mim/Grin2b⁺ B6.Cg-Grin2b^tm1Mim	increased startle reflex	J:89405
Grin2b^tm1Mim/Grin2b^tm1Mim involves: C57BL/6 * CBA	abnormal AMPA-mediated synaptic currents	J:178913
	absence of NMDA-mediated synaptic currents	J:31622
	absent gastric milk in neonates	J:31622
	absent long-term depression	J:31622
	absent suckling reflex	J:31622
	disorganized barrel cortex	J:31622
	neonatal lethality, complete penetrance	J:31622
Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-cre)1Gsc/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	abnormal discrimination learning	J:186311
	abnormal excitatory postsynaptic currents	J:186311
	abnormal excitatory postsynaptic potential	J:186311
	abnormal learning/memory/conditioning	J:186311
	abnormal miniature excitatory postsynaptic currents	J:186311
	abnormal motor coordination/balance	J:186311
	abnormal NMDA-mediated synaptic currents	J:186311
	abnormal object recognition memory	J:186311
	abnormal spatial learning	J:186311
	abnormal spatial reference memory	J:186311
	abnormal spatial working memory	J:186311
	decreased anxiety-related response	J:186311
	decreased body weight	J:186311
	hyperactivity	J:186311
	normal nervous system phenotype	J:186311
	reduced long-term potentiation	J:186311
Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-cre)2Gsc/0 involves: 129S1/Sv * 129X1/SvJ * FVB/N	perinatal lethality, complete penetrance	J:186311
Grin2b^tm1Rsp/Grin2b⁺ involves: 129S1/Sv * 129X1/SvJ	decreased anxiety-related response	J:197485
	impaired coordination	J:197485
	reduced long-term potentiation	J:197485
Grin2b^tm1Rsp/Grin2b^tm1Rsp involves: 129S1/Sv * 129X1/SvJ	abnormal NMDA-mediated synaptic currents	J:45446
Grin2b^tm1Rsp/Grin2b^tm1Rsp involves: 129S1/Sv * 129X1/SvJ	neonatal lethality, complete penetrance	J:45446
Grin2b^tm1Tya/Grin2b^tm1Tya involves: C57BL/6J	abnormal cued conditioning behavior	J:119025
	abnormal nervous system physiology	J:119025
	impaired synaptic plasticity	J:119025
	normal nervous system phenotype	J:119025
Grin2b^tm2Mim/Grin2b^tm2Mim involves: C57BL/6 * CBA	abnormal CNS synaptic transmission	J:76019
	abnormal excitatory postsynaptic potential	J:76019
	abnormal long-term depression	J:76019
	postnatal lethality, complete penetrance	J:76019
Tg(Camk2a-Grin2b)1Jzt/? involves: C57BL/6	enhanced contextual conditioning behavior	J:223086
	enhanced cued conditioning behavior	J:223086
	enhanced long-term object recognition memory	J:223086
	fast extinction of fear memory	J:223086

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