Grin2b Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
MGI:95821

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Grin2b^{tm1(GRIN2A/GRIN2B)Twr}/Grin2b^{tm1(GRIN2A/GRIN2B)Twr} involves: 129S7/SvEvBrd * C57BL/6	abnormal NMDA-mediated synaptic currents	J:116524
	normal behavior/neurological phenotype	J:116524
Grin2b^{tm1.1(Grin2a)Bjha}/Grin2b^{tm1.1(Grin2a)Bjha} involves: 129S6/SvEvTac * C57BL/6	abnormal AMPA-mediated synaptic currents	J:178913
	abnormal miniature excitatory postsynaptic currents	J:178913
	abnormal NMDA-mediated synaptic currents	J:178913
	abnormal social investigation	J:178913
	abnormal social/conspecific interaction behavior	J:178913
	abnormal suckling behavior	J:178913
	decreased body size	J:178913
	increased locomotor activity	J:178913
	perinatal lethality	J:178913
	social withdrawal	J:178913
Grin2b^tm1.1Nhk/Grin2b^tm1.1Nhk involves: 129P2/OlaHsd * C57BL/6J	abnormal operant conditioning behavior	J:197485
	decreased anxiety-related response	J:197485
	enhanced long-term potentiation	J:197485
	impaired coordination	J:197485
	normal nervous system phenotype	J:197485
	reduced long-term potentiation	J:197485
Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-Grin2c/itTA)12Rsp/0 Tg(tetO-cre)LC1Bjd/0 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	abnormal excitatory postsynaptic currents	J:186311
	abnormal NMDA-mediated synaptic currents	J:186311
	abnormal spatial learning	J:186311
	abnormal spatial working memory	J:186311
	normal behavior/neurological phenotype	J:186311
	decreased anxiety-related response	J:186311
	hyperactivity	J:186311

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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