Grin2c Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grin2c
glutamate receptor, ionotropic, NMDA2C (epsilon 3)
MGI:95822

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cacna1a^tm1Kano/Cacna1a^tm1Kano Grin2c^tm2(icre)Mwa/Grin2c⁺ involves: C57BL/6N	normal nervous system phenotype	J:180582
Grin2a^tm1Mim/Grin2a^tm1Mim Grin2c^tm1Mwa/Grin2c^tm1Mwa involves: C57BL/6 * CBA	abnormal motor coordination/balance	J:92648
Grin2a^tm1Nak/Grin2a^tm1Nak Grin2c^tm1Nak/Grin2c^tm1Nak involves: 129S/SvEv	abnormal excitatory postsynaptic currents	J:66455
	abnormal miniature excitatory postsynaptic currents	J:66455
	normal behavior/neurological phenotype	J:66455
	decreased vertical activity	J:66455
	impaired balance	J:66455
	normal nervous system phenotype	J:66455
Grin2a^tm1Rsp/Grin2a^tm1Rsp Grin2c^tm1Rsp/Grin2c^tm1Rsp involves: 129S1/Sv * 129X1/SvJ	impaired contextual conditioning behavior	J:45446
	impaired coordination	J:45446
	normal nervous system phenotype	J:45446
Grin2b^tm1Mony/Grin2b^tm1Mony Tg(Camk2a-Grin2c/itTA)12Rsp/0 Tg(tetO-cre)LC1Bjd/0 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	abnormal excitatory postsynaptic currents	J:186311
	abnormal NMDA-mediated synaptic currents	J:186311
	abnormal spatial learning	J:186311
	abnormal spatial working memory	J:186311
	normal behavior/neurological phenotype	J:186311
	decreased anxiety-related response	J:186311
	hyperactivity	J:186311
Grin2c^{tm1(Grin2b)Ulme}/Grin2c^{tm1(Grin2b)Ulme} involves: 129X1/SvJ * C57BL/6	abnormal cerebellar molecular layer	J:94369
	impaired coordination	J:94369
	thin cerebellar granule layer	J:94369
	thin cerebellar molecular layer	J:94369

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24