Hspa5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hspa5
heat shock protein 5
MGI:95835

54 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hspa5^baffled/Hspa5^baffled FVB.Cg-Hspa5^baffled	abnormal axon extension	J:191772
	abnormal axon fasciculation	J:191772
	abnormal axon morphology	J:191772
	abnormal brain internal capsule morphology	J:191772
	abnormal brain white matter morphology	J:191772
	abnormal cerebellum morphology	J:191772
	abnormal cerebral cortex morphology	J:191772
	abnormal corpus callosum morphology	J:191772
	abnormal cortical intermediate zone morphology	J:191772
	abnormal neuron differentiation	J:191772
	abnormal neuron proliferation	J:191772
	abnormal stratification in cerebral cortex	J:191772
	decreased body size	J:191772
	decreased surfactant secretion	J:191772
	forebrain hypoplasia	J:191772
	neonatal lethality, complete penetrance	J:191772
	normal nervous system phenotype	J:191772
	respiratory failure	J:191772
Hspa5^baffled/Hspa5^baffled Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N	abnormal axon extension	J:168258
	abnormal axon fasciculation	J:168258
	abnormal cerebral cortex morphology	J:168258
	abnormal cortical intermediate zone morphology	J:168258
	abnormal hippocampus morphology	J:168258
	abnormal telencephalon morphology	J:168258
	cleft palate	J:168258
	hematoma	J:168258
	neonatal lethality, complete penetrance	J:168258
	respiratory distress	J:168258
	small kidney	J:168258
	small olfactory bulb	J:168258
Hspa5^{tm1.1(KOMP)Vlcg}/Hspa5⁺ C57BL/6N-Hspa5^{tm1.1(KOMP)Vlcg}/J	decreased circulating chloride level	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased heart weight	J:211773
Hspa5^{tm1.1(KOMP)Vlcg}/Hspa5^{tm1.1(KOMP)Vlcg} C57BL/6N-Hspa5^{tm1.1(KOMP)Vlcg}/J	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Hspa5^tm1.1Alee/Hspa5^tm1.1Alee involves: 129 * C57BL/6 * FVB/N	abnormal blastocyst morphology	J:111416
	abnormal inner cell mass apoptosis	J:111416
	absent inner cell mass proliferation	J:111416
	embryonic lethality at implantation, complete penetrance	J:111416
	empty decidua capsularis	J:111416
	failure of blastocyst to hatch from the zona pellucida	J:111416
Hspa5^tm1Alee/Hspa5^tm1Alee involves: 129 * C57BL/6	no abnormal phenotype detected	J:111416
Hspa5^tm1Alee/Hspa5^tm1Alee Tg(Pbsn-cre)4Prb/0 involves: 129 * C57BL/6 * DBA/2	normal reproductive system phenotype	J:142106
Hspa5^tm1Aoe/Hspa5⁺ B6.129-Hspa5^tm1Aoe	abnormal renal tubule morphology	J:130961
	dilated renal tubule	J:130961
	increased susceptibility to injury	J:130961
	renal interstitial fibrosis	J:130961
	renal tubule atrophy	J:130961
Hspa5^tm1Aoe/Hspa5^tm1Aoe involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal alveolar lamellar body morphology	J:131209
	abnormal pulmonary alveolus epithelial cell morphology	J:131209
	abnormal surfactant secretion	J:131209
	abnormal type II pneumocyte morphology	J:131209
	atelectasis	J:131209
	cyanosis	J:131209
	decreased fetal size	J:131209
	neonatal lethality, complete penetrance	J:131209
	pallor	J:131209
	pulmonary alveolar hemorrhage	J:131209
	respiratory distress	J:131209

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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