H2-D1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2-D1
histocompatibility 2, D region locus 1
MGI:95896

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Unc/B2m^tm1Unc H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe involves: 129P2/OlaHsd * C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:41077
H2-Ab1^g7-em1Dvs/H2-Ab1^g7-em1Dvs H2-D1^b-em5Dvs/H2-D1^b-em5Dvs H2-K1^d-em1Dvs/H2-K1^d-em1Dvs NOD/ShiLtDvs-H2-K1^d-em1Dvs H2-Ab1^g7-em1Dvs H2-D1^em5Dvs/Dvs	abnormal T cell subpopulation ratio	J:257229
	decreased alpha-beta T cell number	J:257229
	decreased CD4-positive, alpha-beta T cell number	J:257229
	decreased susceptibility to autoimmune diabetes	J:257229
H2-D1^b-em5Dvs/H2-D1^b-em5Dvs H2-K1^d-em1Dvs/H2-K1^d-em1Dvs NOD/ShiLtDvs-H2-K1^d-em1Dvs H2-D1^b-em5Dvs/Dvs	abnormal T cell subpopulation ratio	J:257229
	decreased susceptibility to autoimmune diabetes	J:257229
H2-D1^b-em5Dvs/H2-D1^b-em5Dvs H2-K1^d-em1Dvs/H2-K1^d-em1Dvs Tg(HLA-A/H2-D/B2M)1Dvs/? NOD/ShiLtDvs-H2-K1^d-em1Dvs H2-D1^b-em5Dvs Tg(HLA-A/H2-D/B2M)1Dvs/Dvs	autoimmune response	J:257229
	increased susceptibility to autoimmune diabetes	J:257229
	insulitis	J:257229
H2-D1^b-em5Dvs/H2-D1^b-em5Dvs H2-K1^d-em1Dvs/H2-K1^d-em1Dvs Tg(HLA-B39/H2-D/B2m)2Dvs/? NOD/ShiLtDvs-H2-K1^d-em1Dvs H2-D1^b-em5Dvs Tg(HLA-B39/H2-D/B2M)2Dvs/Dvs	autoimmune response	J:257229
	increased susceptibility to autoimmune diabetes	J:257229
	insulitis	J:257229
H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe B6.129P-H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe	abnormal cytotoxic T cell physiology	J:118960
H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe involves: 129P2/OlaHsd * C57BL/6	abnormal glutamate-mediated receptor currents	J:148342
	absent CD8-positive, alpha-beta T cells	J:57703
	decreased CD8-positive, alpha-beta T cell number	J:54709
	decreased susceptibility to Riboviria infection induced morbidity/mortality	J:54709
	enhanced coordination	J:148342
	enhanced paired-pulse facilitation	J:148342
	increased CD4-positive, alpha-beta T cell number	J:54709
	increased synaptic depression	J:148342
	normal nervous system phenotype	J:148342
H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe Klra1^tm1.1Wyok/Klra1^tm1.1Wyok involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac	normal hematopoietic system phenotype	J:252851
H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe Klra1^tm1.1Wyok/Klra1^tm1.1Wyok Tg(H2-D^d)28Bee/0 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2	abnormal NK cell physiology	J:252851
	normal hematopoietic system phenotype	J:252851
H2-D1^b-tm1Bpe/H2-D1^b-tm1Bpe H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe X/Yaa BXSB.129P2(B6)-H2-K1^b-tm1Bpe H2-D1^b-tm1Bpe/Dcr	increased susceptibility to systemic lupus erythematosus	J:179430
	premature death	J:179430

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24