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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
H2-Ea
histocompatibility 2, class II antigen E alpha
MGI:95900
32 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
brain inflammation J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
brain inflammation J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
involves: 129S2/SvPas * C57BL/6
normal nervous system phenotype J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
abnormal axon morphology J:189816
abnormal cytokine secretion J:189816
abnormal motor capabilities/coordination/movement J:189816
axon degeneration J:189816
brain inflammation J:189816
CNS inflammation J:189816
increased CD4-positive, alpha-beta T cell number J:189816
increased inflammatory response J:189816
increased interferon-gamma secretion J:189816
increased interleukin-17 secretion J:189816
increased susceptibility to experimental autoimmune encephalomyelitis J:189816
increased T-helper 1 cell number J:189816
increased T-helper 17 cell number J:189816
neuron degeneration J:189816
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)loKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
involves: 129S2/SvPas * C57BL/6
brain inflammation J:189816
increased susceptibility to experimental autoimmune encephalomyelitis J:189816
Tg(Igk-Eik-H2-Ead)1Flv/0
Tg(Tcra1H3.1,Tcrb1H3.1)1Vire/0
involves: C57BL/6 * SJL
decreased double-positive T cell number J:124574
thymus hypoplasia J:124574
Tg(Ins2-CD80)3B7Flv/0
Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri/0
involves: C57BL/6 * CBA/Ca * SJL
abnormal pancreatic islet morphology J:93555
dehydration J:93555
increased susceptibility to autoimmune diabetes J:93555
insulitis J:93555
premature death J:93555
weight loss J:93555
Tg(Ins2-CD86)12B70Flv/0
Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri/0
involves: C57BL/6 * CBA/Ca * SJL
abnormal cytokine secretion J:93555
decreased pancreatic beta cell number J:93555
dehydration J:93555
increased circulating glucose level J:93555
increased susceptibility to autoimmune diabetes J:93555
insulitis J:93555
premature death J:93555
weight loss J:93555
Tg(Ins2-H2-Ead,Ins2-H2-Eb1b)187-7Bri/0
involves: C57BL/6 * SJL
decreased insulin secretion J:127706
decreased susceptibility to autoimmune diabetes J:93555
hyperglycemia J:127706
increased circulating glucose level J:93555, J:127706
increased circulating triglyceride level J:127706
ketoaciduria J:127706
polydipsia J:127706
polyuria J:127706

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory