H2-K1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2-K1
histocompatibility 2, K1, K region
MGI:95904

20 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
H2-K1^b-tm1Bpe/H2-K1^b-tm1Bpe involves: 129P2/OlaHsd * C57BL/6	decreased CD8-positive, alpha-beta T cell number	J:54709
	increased CD4-positive, alpha-beta T cell number	J:54709
H2-K1^d-em4Dvs/H2-K1^d-em4Dvs NOD/ShiLtDvs-H2-K1^d-em4Dvs/Dvs	abnormal immune system physiology	J:257229
	decreased susceptibility to autoimmune diabetes	J:257229
H2-K1^d-em5Dvs/H2-K1^d-em5Dvs NOD/ShiLtDvs-H2-K1^d-em5Dvs/Dvs	abnormal immune system physiology	J:257229
	decreased susceptibility to autoimmune diabetes	J:257229
H2-K1^d-em7Dvs/H2-K1^d-em7Dvs NOD/ShiLtDvs-H2-K1^d-em7Dvs/Dvs	abnormal immune system physiology	J:257229
	decreased susceptibility to autoimmune diabetes	J:257229
Tg(CKMM-tTA)A3Rhvh/0 Tg(tetO-H2-K1)#Papl/0 B6.Cg-Tg(CKMM-tTA)A3Rhvh Tg(tetO-H2-K1)#Papl	abnormal circulating enzyme level	J:205907
	abnormal cytokine level	J:205907
	abnormal skeletal muscle morphology	J:205907
	abnormal spine curvature	J:205907
	cachexia	J:205907
	decreased body weight	J:205907
	decreased locomotor activity	J:205907
	increased anti-nuclear antigen antibody level	J:205907
	increased autoantibody level	J:205907
	increased circulating creatine kinase level	J:205907
	normal mortality/aging	J:205907
	muscle weakness	J:205907
	myositis	J:205907
	perinatal lethality, complete penetrance	J:205907
	skeletal muscle fiber atrophy	J:205907
	skeletal muscle fiber degeneration	J:205907

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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