H2-DMa Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

H2-DMa
histocompatibility 2, class II, locus DMa
MGI:95921

18 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
H2-DMa^tm1Doi/H2-DMa^tm1Doi involves: 129S2/SvPas * C57BL/6	abnormal professional antigen presenting cell physiology	J:31624
H2-DMa^tm1Doi/H2-DMa^tm1Doi involves: 129S2/SvPas * C57BL/6	normal immune system phenotype	J:31624
H2-DMa^tm1Liz/H2-DMa^tm1Liz involves: BALB/cJ	abnormal antigen presentation via MHC class II	J:113714
	abnormal CD4-positive, alpha beta T cell morphology	J:113714
	abnormal professional antigen presenting cell physiology	J:111565, J:113714
	defective assembly of class II molecules	J:113714
H2-DMa^tm1Lkrl/H2-DMa^tm1Lkrl involves: 129P2/OlaHsd	abnormal antigen presentation	J:31786
	abnormal CD4-positive, alpha-beta T cell physiology	J:31786
	abnormal positive T cell selection	J:31786
	abnormal professional antigen presenting cell physiology	J:31786
	decreased CD4-positive, alpha-beta T cell number	J:31786
H2-DMa^tm1Luc/H2-DMa^tm1Luc B6.129S4-H2-Dma^tm1Luc	abnormal antigen presentation	J:125654
	abnormal T-helper 1 physiology	J:125654
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:125654
	decreased susceptibility to type IV hypersensitivity reaction	J:125654
H2-DMa^tm1Luc/H2-DMa^tm1Luc involves: 129S4/SvJae	abnormal antigen presentation via MHC class II	J:31625
	abnormal CD4-positive, alpha-beta T cell physiology	J:31625
	abnormal level of surface class II molecules	J:45185
	abnormal positive T cell selection	J:125548
	decreased body size	J:31625
	decreased CD4-positive, alpha-beta T cell number	J:31625, J:45185
	decreased interferon-gamma secretion	J:45185
	increased susceptibility to bacterial infection	J:45185
	premature death	J:31625
H2-DMa^tm1Luc/H2-DMa^tm1Luc involves: 129S4/SvJae * C57BL/6	abnormal antigen presentation	J:72243
H2-DMa^tm1Luc/H2-DMa^tm1Luc involves: 129S4/SvJae * C57BL/6	decreased susceptibility to experimental autoimmune encephalomyelitis	J:72243
H2-DMa^tm2Liz/H2-DMa^tm2Liz involves: C57BL/6 * C57BL/10 * C57BR * CBA	abnormal antigen presentation via MHC class II	J:111565
	abnormal professional antigen presenting cell physiology	J:111565
	decreased T cell proliferation	J:111565

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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