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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hat1
histone aminotransferase 1
MGI:96013
48 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hat1tm1.1Mrpa/Hat1+
B6.Cg-Hat1tm1.1Mrpa 		abnormal double-strand DNA break repair J:296531
abnormal interventricular septum morphology J:296531
decreased abdominal adipose tissue amount J:296531
decreased birth body size J:296531
decreased body weight J:296531
decreased fat cell size J:296531
decreased skeletal muscle mass J:296531
decreased subcutaneous adipose tissue amount J:296531
decreased total body fat amount J:296531
early cellular replicative senescence J:296531
hindlimb paralysis J:296531
increased histiocytic sarcoma incidence J:296531
increased kidney tumor incidence J:296531
increased liver tumor incidence J:296531
increased spleen neoplasm incidence J:296531
increased tumor incidence J:296531
lordokyphosis J:296531
muscle degeneration J:296531
muscular atrophy J:296531
oxidative stress J:296531
premature aging J:296531
premature death J:296531
skeletal muscle atrophy J:296531
skeletal muscle degeneration J:296531
weight loss J:296531
Hat1tm1.1Mrpa/Hat1tm1.1Mrpa
B6.Cg-Hat1tm1.1Mrpa 		abnormal double-strand DNA break repair J:296531
abnormal mitochondrial physiology J:296531
decreased fibroblast proliferation J:296531
disorganized mitochondrial cristae J:296531
early cellular replicative senescence J:296531
increased mitochondrial size J:296531
oxidative stress J:296531
Hat1tm1.1Mrpa/Hat1tm1.1Mrpa
involves: C57BL/6J 		abnormal craniofacial morphology J:199077
abnormal cranium morphology J:199077
abnormal lung development J:199077
abnormal lung interstitium morphology J:199077
abnormal mandible morphology J:199077
abnormal mitosis J:199077
abnormal nose morphology J:199077
abnormal respiratory system physiology J:199077
abnormal vertebrae morphology J:199077
absent mandible J:199077
decreased birth body size J:199077
decreased fibroblast proliferation J:199077
increased bone mineral density J:199077
neonatal lethality, complete penetrance J:199077
perinatal lethality, complete penetrance J:199077
prenatal lethality, incomplete penetrance J:199077
primary atelectasis J:199077
respiratory failure J:199077
thick lung-associated mesenchyme J:199077
thick pulmonary interalveolar septum J:199077
Hat1tm1Mrpa/Hat1+
involves: C57BL/6 		no abnormal phenotype detected J:199077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory