About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hbb
hemoglobin beta chain complex
MGI:96020
109 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Not Specified 		abnormal erythrocyte morphology J:134980
abnormal kidney corticomedullary boundary morphology J:134980
abnormal Kupffer cell morphology J:134980
abnormal liver morphology J:134980
abnormal spleen white pulp morphology J:134980
anemia J:137709
anisocytosis J:134980
decreased erythrocyte cell number J:134980
decreased hematocrit J:134980
decreased hemoglobin content J:134980
decreased urine osmolality J:134980
enlarged spleen J:134980
extramedullary hematopoiesis J:134980
focal hepatic necrosis J:134980
increased liver iron level J:134980
increased spleen red pulp amount J:134980
kidney vascular congestion J:134980
liver vascular congestion J:134980
poikilocytosis J:134980
polychromatophilia J:134980
reticulocytosis J:134980
spleen vascular congestion J:134980
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4+
involves: 129 * BALB/c * C57BL/6J 		abnormal erythrocyte physiology J:227339
abnormal liver morphology J:227339
abnormal lung morphology J:227339
abnormal pulmonary circulation J:227339
abnormal renal tubule morphology J:227339
enlarged spleen J:227339
hepatic necrosis J:227339
increased mesangial cell number J:227339
liver inflammation J:227339
microcytic anemia J:227339
premature death J:227339
reticulocytosis J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm2(HBG1,HBB*)Tow
Slc12a4Rbc10/Slc12a4Rbc10
involves: 129 * BALB/c * C57BL/6J 		premature death J:227339
preweaning lethality, incomplete penetrance J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow
Not Specified 		anemia J:137709
normal hematopoietic system phenotype J:134980
normal liver/biliary system phenotype J:134980
normal renal/urinary system phenotype J:134980
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow
Slc12a4Rbc10/Slc12a4Rbc10
involves: 129 * BALB/c * C57BL/6J 		microcytic anemia J:227339
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBD,HBB*)Ryan/Hbbtm2(HBG1,HBD,HBB*)Ryan
Not Specified 		abnormal proerythroblast morphology J:148521
anemia J:148521
anisopoikilocytosis J:148521
decreased hemoglobin content J:148521
decreased mean corpuscular volume J:148521
extramedullary hematopoiesis J:148521
hemolytic anemia J:148521
increased circulating bilirubin level J:148521
intermingled spleen red and white pulp J:148521
low mean erythrocyte cell number J:148521
polychromatophilia J:148521
premature death J:148521
reticulocytosis J:148521
spherocytosis J:148521
spleen hyperplasia J:148521
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm2(HBG1,HBD,HBB*)Ryan/Hbbtm3(HBG1,HBB)Tow
Not Specified 		abnormal definitive hematopoiesis J:148521
decreased hemoglobin content J:148521
decreased mean corpuscular volume J:148521
high mean erythrocyte cell number J:148521
reticulocytosis J:148521
spleen hyperplasia J:148521
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm3(HBG1,HBB)Tow/Hbbtm3(HBG1,HBB)Tow
Not Specified 		anemia J:137709
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm4(HBB*)Tow/Hbbtm4(HBB*)Tow
Not Specified 		abnormal erythrocyte physiology J:137709
anemia J:137709
normal cardiovascular system phenotype J:137709
Hbatm1(HBA)Tow/Hbatm1(HBA)Tow
Hbbtm5(HBG1,HBB*)Tow/Hbbtm5(HBG1,HBB*)Tow
Not Specified 		abnormal erythrocyte physiology J:137709
anemia J:137709
normal cardiovascular system phenotype J:137709
Hbatm1Paz/Hba+
Hbbtm1Tow/Hbbtm1Tow
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal erythroid progenitor cell morphology J:204029
decreased erythroid progenitor cell number J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbb+
involves: 129S2/SvPas * 129S7/SvEvBrd 		normal hematopoietic system phenotype J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal embryonic erythrocyte morphology J:204029
abnormal embryonic erythropoiesis J:204029
abnormal erythroid progenitor cell morphology J:204029
decreased embryo size J:204029
decreased erythroid progenitor cell number J:204029
embryonic lethality during organogenesis, complete penetrance J:204029
liver hypoplasia J:204029
microcytic anemia J:204029
microcytosis J:204029
pallor J:204029
small liver J:204029
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/0
involves: 129 * Black Swiss * C57BL/6 * DBA/2 * FVB/N 		abnormal penile erection J:135978
priapism J:135978
Hbatm1Paz/Hbatm1Paz
Hbbtm1Tow/Hbbtm1Tow
Tg(HBA-HBBs)41Paz/?
involves: 129S2/SvPas * 129S7/SvEvBrd * Black Swiss * C57BL/6 * DBA/2* FVB/N 		abnormal erythrocyte morphology J:44161
abnormal hemoglobin J:44161
abnormal kidney vasculature morphology J:44161
abnormal liver vasculature morphology J:44161
abnormal lung vasculature morphology J:44161
anemia J:44161
anisopoikilocytosis J:44161
decreased erythrocyte osmotic fragility J:44161
decreased hematocrit J:44161
decreased mean corpuscular hemoglobin J:44161
decreased mean corpuscular hemoglobin concentration J:44161
decreased mean corpuscular volume J:44161
hypoxia J:44161
increased heart weight J:44161
increased kidney iron level J:44161
increased kidney weight J:44161
increased liver iron level J:44161
increased spleen weight J:44161
kidney atrophy J:44161
kidney cyst J:44161
neonatal lethality, incomplete penetrance J:44161
renal fibrosis J:44161
reticulocytosis J:44161
spleen vascular congestion J:44161
Hbbd3th/Hbb+
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0
involves: FVB/N * Swiss Webster 		abnormal erythrocyte morphology J:94190
abnormal urine homeostasis J:94190
anemia J:94190
decreased urine osmolality J:94190
increased circulating alanine transaminase level J:94190
increased circulating aspartate transaminase level J:94190
reticulocytosis J:94190
Hbbd3th/Hbb+
Tg(LCR-HBA1,LCR-HBB*)1Tow/0
involves: C57BL/6 * DBA/2J * SJL 		anemia J:127701
anisopoikilocytosis J:127701
decreased erythrocyte cell number J:127701
decreased hematocrit J:127701
decreased hemoglobin content J:127701
echinocytosis J:127701
enlarged spleen J:127701
reticulocytosis J:127701
Hbbd3th/Hbb+
Tg(LCR-HBA2,LCR-HBB*)1Cos/0
involves: C57BL/6J * CBA/J * DBA/2J 		abnormal erythrocyte morphology J:94193
abnormal gas homeostasis J:94193
abnormal hemoglobin J:94193
anemia J:94193
decreased hematocrit J:94193
decreased mean corpuscular volume J:94193
enlarged spleen J:94193
increased mean corpuscular hemoglobin concentration J:94193
increased susceptibility to induced morbidity/mortality J:94193
maternal effect J:94193
postnatal lethality, incomplete penetrance J:94193
reticulocytosis J:94193
Hbbd3th/Hbbd3th
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
involves: Swiss Webster 		abnormal erythrocyte morphology J:136653
abnormal mean corpuscular volume J:136653
normal hematopoietic system phenotype J:136653
reticulocytosis J:94190
Hbbd3th/Hbbd3th
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0
involves: FVB/N * Swiss Webster 		abnormal brain morphology J:94190
abnormal erythrocyte morphology J:94190
abnormal hemoglobin J:94190
abnormal kidney afferent arteriole morphology J:94190
abnormal liver morphology J:94190
abnormal neuron morphology J:94190
abnormal spleen morphology J:94190
abnormal urine homeostasis J:94190
anemia J:94190
brain vascular congestion J:94190
decreased urine osmolality J:94190
enlarged kidney J:94190
enlarged liver J:94190
enlarged spleen J:94190
glomerular capillary congestion J:94190
increased circulating alanine transaminase level J:94190
increased circulating aspartate transaminase level J:94190
increased mean corpuscular hemoglobin J:94190
increased spleen red pulp amount J:94190
liver fibrosis J:94190
postnatal lethality J:94190
premature death J:94190
pulmonary alveolar hemorrhage J:94190
pulmonary interstitial fibrosis J:94190
pulmonary vascular congestion J:94190
renal fibrosis J:94190
reticulocytosis J:94190
spleen fibrosis J:94190
spleen vascular congestion J:94190
thick pulmonary interalveolar septum J:94190
Hbbd3th/Hbbd3th
Tg(LCR-HBA2,LCR-HBB)11Cos/0
involves: FVB/N 		abnormal erythrocyte morphology J:94190
increased mean corpuscular hemoglobin J:94190
reticulocytosis J:94190
Hbbtm1.1(HBG1,HBB*)Ryan/Hbb+
involves: C57BL/6J 		abnormal bone marrow cavity morphology J:147906
abnormal iron level J:147906
abnormal spleen morphology J:147906
anisopoikilocytosis J:147906
decreased erythrocyte cell number J:147906
decreased mean corpuscular hemoglobin J:147906
decreased mean corpuscular hemoglobin concentration J:147906
decreased mean corpuscular volume J:147906
enlarged spleen J:147906
extramedullary hematopoiesis J:147906
increased erythroid progenitor cell number J:147906
increased hemoglobin concentration distribution width J:147906
increased liver iron level J:147906
increased spleen iron level J:147906
increased spleen red pulp amount J:147906
intermingled spleen red and white pulp J:147906
microcytic anemia J:147906
reticulocytosis J:147906
Hbbtm1.1(HBG1,HBB*)Ryan/Hbbtm1.1(HBG1,HBB*)Ryan
involves: C57BL/6J 		perinatal lethality, complete penetrance J:147906
Hbbtm2Unc/Hbb+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal erythrocyte morphology J:64295
anisocytosis J:64295
decreased erythrocyte cell number J:64295
decreased hematocrit J:64295
decreased hemoglobin content J:64295
decreased mean corpuscular volume J:64295
enlarged spleen J:64295
extramedullary hematopoiesis J:64295
increased hemoglobin concentration distribution width J:64295
increased kidney iron level J:64295
increased liver iron level J:64295
increased mean corpuscular hemoglobin concentration J:64295
increased spleen iron level J:64295
poikilocytosis J:64295
Hbbtm2Unc/Hbbtm2Unc
involves: 129P2/OlaHsd * C57BL/6J 		decreased birth body size J:64295
pallor J:64295
postnatal lethality, complete penetrance J:64295
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory