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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hbb-b1
hemoglobin, beta adult major chain
MGI:96021
44 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hbb-b1MommeD7/Hbb-b1+
involves: FVB/N 		abnormal definitive hematopoiesis J:190446
anisocytosis J:190446
anisopoikilocytosis J:190446
decreased mean corpuscular hemoglobin J:190446
decreased mean corpuscular volume J:190446
enlarged spleen J:142335, J:190446
extramedullary hematopoiesis J:190446
hypochromic microcytic anemia J:190446
increased erythrocyte clearance J:190446
increased nucleated erythrocyte cell number J:190446
increased red blood cell distribution width J:190446
increased spleen red pulp amount J:190446
leptocytosis J:190446
microcytic anemia J:190446
poikilocytosis J:190446
polychromatophilia J:190446
reticulocytosis J:142335
schistocytosis J:190446
spherocytosis J:190446
Hbb-b1MommeD7/Hbb-b1MommeD7
involves: FVB/N 		abnormal liver morphology J:190446
decreased erythrocyte cell number J:142335
lethality throughout fetal growth and development, complete penetrance J:190446
liver hypoplasia J:190446
pallor J:142335, J:190446
postnatal lethality J:142335
Hbb-b1Rbc13/Hbb-b1+
involves: BALB/c * C57BL/6 		abnormal definitive hematopoiesis J:190446
anisocytosis J:190446
anisopoikilocytosis J:190446
decreased mean corpuscular hemoglobin J:190446
decreased mean corpuscular volume J:190446
enlarged spleen J:190446
extramedullary hematopoiesis J:190446
hypochromic microcytic anemia J:190446
increased erythrocyte clearance J:190446
increased nucleated erythrocyte cell number J:190446
increased red blood cell distribution width J:190446
increased spleen red pulp amount J:190446
leptocytosis J:190446
microcytic anemia J:190446
poikilocytosis J:190446
polychromatophilia J:190446
schistocytosis J:190446
spherocytosis J:190446
Hbb-b1Rbc13/Hbb-b1MommeD7
involves: BALB/c * C57BL/6 * FVB/N 		pallor J:190446
Hbb-b1Rbc13/Hbb-b1Rbc13
involves: BALB/c * C57BL/6 		abnormal liver morphology J:190446
lethality throughout fetal growth and development, complete penetrance J:190446
liver hypoplasia J:190446
pallor J:190446
Hbb-b1tm1Shs/Hbb-b1+
involves: C57BL/6CrSlc 		abnormal aerobic respiration J:81902
abnormal hemoglobin J:81902
abnormal skeletal muscle fiber type ratio J:81902
acidosis J:81902
anemia J:81902
decreased hemoglobin content J:81902
decreased pulmonary ventilation J:81902
hyperoxia J:81902
increased aerobic running capacity J:81902
increased carbon dioxide production J:81902
increased oxygen consumption J:81902
Hbb-b1tm1Shs/Hbb-b1tm1Shs
involves: C57BL/6 		abnormal erythrocyte physiology J:78271
abnormal erythropoiesis J:78271
anisopoikilocytosis J:78271
decreased erythrocyte cell number J:78271
decreased hematocrit J:78271
decreased mean corpuscular hemoglobin J:78271
decreased mean corpuscular volume J:78271
enlarged spleen J:78271
extramedullary hematopoiesis J:78271
hemolytic anemia J:78271
hypochromic anemia J:78271
increased erythroid progenitor cell number J:78271
increased number of Heinz bodies J:78271
increased spleen iron level J:78271
reticulocytosis J:78271
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory