Hck Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hck
hemopoietic cell kinase
MGI:96052

23 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hck^tm1Ern/Hck^tm1Ern involves: 129S1/Sv * C57BL/6	abnormal alveolar macrophage morphology	J:111432
	abnormal enzyme/coenzyme activity	J:111432
	abnormal immune system physiology	J:111432
	abnormal macrophage physiology	J:111432
	abnormal pulmonary alveolus morphology	J:111432
	abnormal respiratory epithelium morphology	J:111432
	atelectasis	J:111432
	decreased lung elastance	J:111432
	emphysema	J:111432
	increased circulating tumor necrosis factor level	J:111432
	increased eosinophil cell number	J:111432
	increased interleukin-5 secretion	J:111432
	increased lung adenocarcinoma incidence	J:111432
	lung inflammation	J:111432
	overexpanded pulmonary alveolus	J:111432
	pulmonary fibrosis	J:111432
	pulmonary hyperplasia	J:111432
	respiratory distress	J:111432
	respiratory epithelium hypertrophy	J:111432
	thick pulmonary interalveolar septum	J:111432
Hck^tm1Hev/Hck^tm1Hev B6.129S7-Hck^tm1Hev	abnormal inflammatory response	J:113463
Hck^tm1Hev/Hck^tm1Hev B6.129S7-Hck^tm1Hev	abnormal neutrophil physiology	J:113463
Hck^tm1Hev/Hck^tm1Hev involves: 129S7/SvEvBrd * C57BL/6J	impaired macrophage phagocytosis	J:16994

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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