Hck Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hck
hemopoietic cell kinase
MGI:96052

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Fgr^tm1Hev/Fgr^tm1Hev Hck^tm1Hev/Hck^tm1Hev involves: 129S7/SvEvBrd * C57BL/6J	abnormal macrophage morphology	J:59037
	abnormal macrophage physiology	J:59037
	decreased angiogenesis	J:89137
	impaired macrophage phagocytosis	J:16994
	increased susceptibility to bacterial infection	J:16994
Fgr^tm1Hev/Fgr^tm1Hev Hck^tm1Hev/Hck^tm1Hev Lyn^tm1Sor/Lyn^tm1Sor B6.Cg-Hck^tm1Hev Fgr^tm1Hev Lyn^tm1Sor	abnormal inflammatory response	J:113463
	abnormal neutrophil physiology	J:113463
Hck^tm1Hev/Hck^tm1Hev Src^tm1Sor/Src^tm1Sor involves: 129S7/SvEvBrd * C57BL/6J	abnormal bone marrow cavity morphology	J:31647
	abnormal immune system organ morphology	J:31647
	abnormal long bone diaphysis morphology	J:31647
	abnormal skeleton development	J:31647
	abnormal spleen germinal center morphology	J:31647
	abnormal spleen morphology	J:31647
	abnormal splenic cell ratio	J:31647
	abnormal trabecular bone morphology	J:31647
	anemia	J:31647
	decreased bone marrow cell number	J:31647
	decreased leukocyte cell number	J:31647
	increased macrophage cell number	J:31647
	lymph node hypoplasia	J:31647
	perinatal lethality, incomplete penetrance	J:31647
	postnatal growth retardation	J:31647
	premature death	J:31647
	thymus hypoplasia	J:31647

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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