Ptpn6 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ptpn6
protein tyrosine phosphatase, non-receptor type 6
MGI:96055

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Btk^xid/? Ptpn6^me/Ptpn6^me involves: C57BL/6J * CBA/N * NFS	abnormal skin condition	J:30994
	absent limbs	J:30994
	decreased body weight	J:30994
	increased autoantibody level	J:30994
	increased IgM level	J:30994
	increased splenocyte proliferation	J:30994
	premature death	J:30994
Cd22^tm1Eac/Cd22⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal B cell negative selection	J:110531
	abnormal mature B cell morphology	J:110531
Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal B cell negative selection	J:110531
	abnormal mature B cell morphology	J:110531
	increased IgM level	J:110531
Ighm^tm1Cgn/Ighm^tm1Cgn Ptpn6^me-v/Ptpn6^me-v involves: 129S7/SvEvBrd * C57BL/6J	decreased retina photoreceptor cell number	J:108375
	retina photoreceptor degeneration	J:108375
Iglc1^tm2Ust/Iglc1^tm2Ust Ptpn6^me-v/Ptpn6^me-v involves: 129S7/SvEvBrd * C57BL/6J	decreased B cell number	J:113218
Irak4^m1Btlr/Irak4^m1Btlr Ptpn6^m1Btlr/Ptpn6^m1Btlr C57BL/6J-Ptpn6^m1Btlr Irak4^m1Btlr	normal immune system phenotype	J:142845
Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal mature B cell morphology	J:110531
Myd88^poc/Myd88^poc Ptpn6^m1Btlr/Ptpn6^m1Btlr C57BL/6J-Ptpn6^m1Btlr Myd88^poc	normal immune system phenotype	J:142845
Ptpn6^m1Btlr/Ptpn6^m1Btlr Stat1^m1Btlr/Stat1^m1Btlr C57BL/6J-Stat1^m1Btlr Ptpn6^m1Btlr	ulcerated autopod	J:142845
Ptpn6^m1Btlr/Ptpn6^m1Btlr Ticam1^Lps2/Ticam1^Lps2 C57BL/6J-Ptpn6^m1Btlr Ticam1^Lps2	ulcerated autopod	J:142845
Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal mature B cell morphology	J:110531
Ptpn6^me-v/Ptpn6^me-v involves: 129S7/SvEvBrd * C57BL/6J	decreased retina photoreceptor cell number	J:108375
Ptpn6^me-v/Ptpn6^me-v involves: 129S7/SvEvBrd * C57BL/6J	retina photoreceptor degeneration	J:108375

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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