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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Htt
huntingtin
MGI:96067
150 phenotypes from 21 alleles in 20 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Httem1(IMPC)H/Htt+
C57BL/6NTac-Httem1(IMPC)H/H 		increased grip strength J:211773
Httem1(IMPC)H/Httem1(IMPC)H
C57BL/6NTac-Httem1(IMPC)H/H 		embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Htttm1.1Pfs/Htt+
involves: 129S4/SvJae * C57BL/6 		decreased brain size J:54906
increased aggression towards mice J:54906
Htttm1.1Tna/Htt+
involves: 129P2/OlaHsd * C57BL/6J 		astrocytosis J:76017
Htttm1.1Tna/Htttm1.1Tna
involves: 129P2/OlaHsd * C57BL/6J 		astrocytosis J:76017
Htttm1Detl/Htt+
involves: 129P2/OlaHsd * C57BL/6J 		normal behavior/neurological phenotype J:67074
decreased body size J:67074
decreased locomotor activity J:67074
normal homeostasis/metabolism phenotype J:67074
impaired limb coordination J:67074
normal nervous system phenotype J:67074
Htttm1Detl/Htttm1Detl
involves: 129P2/OlaHsd * C57BL/6J 		normal behavior/neurological phenotype J:67074
decreased body size J:67074
normal homeostasis/metabolism phenotype J:67074
impaired limb coordination J:67074
normal nervous system phenotype J:67074
neuron degeneration J:67074
tonic-clonic seizures J:67074
Htttm1Hay/Htt+
involves: C57BL/6J 		abnormal globus pallidus morphology J:25941
abnormal learning/memory/conditioning J:25941
abnormal subthalamic nucleus morphology J:25941
hyperactivity J:25941
hyperresponsive J:25941
Htttm1Hay/Htttm1Hay
involves: C57BL/6J 		abnormal extraembryonic tissue morphology J:25941
abnormal gastrulation J:25941
decreased embryo size J:25941
embryonic growth arrest J:25941
embryonic lethality between implantation and placentation, incomplete penetrance J:25941
embryonic lethality during organogenesis, complete penetrance J:25941
Htttm1Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		no abnormal phenotype detected J:27183
Htttm1Mem/Htttm1Mem
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 		abnormal developmental patterning J:27183
abnormal ectoderm development J:27183
abnormal embryonic tissue morphology J:27183
abnormal extraembryonic endoderm formation J:27183
abnormal extraembryonic mesoderm development J:27183
abnormal extraembryonic tissue morphology J:27183
absent primitive node J:27183
decreased embryo size J:27183
embryonic lethality between somite formation and embryo turning, complete penetrance J:27183
embryonic-extraembryonic boundary constriction J:27183
increased ectoderm apoptosis J:27183
Htttm1Mem/Htttm3Mem
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:44391
Htttm1Mem/Htttm6Mem
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal motor capabilities/coordination/movement J:72915
decreased body size J:72915
enlarged lateral ventricles J:72915
Htttm1Mem/Htttm6Mem
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster 		abnormal cerebellum lobule morphology J:260244
abnormal cerebral cortex morphology J:260244
abnormal gait J:260244
abnormal lateral ganglionic eminence morphology J:260244
abnormal nervous system development J:260244
abnormal oligodendrocyte morphology J:260244
abnormal primary motor cortex morphology J:260244
astrocytosis J:260244
axon degeneration J:260244
normal behavior/neurological phenotype J:260244
decreased body weight J:260244
dysmyelination J:260244
ectopic neuron J:260244
environmentally induced seizures J:260244
gliosis J:260244
hyperactivity J:260244
impaired coordination J:260244
limb grasping J:260244
lordokyphosis J:260244
muscular atrophy J:260244
neurodegeneration J:260244
neuronal cytoplasmic inclusions J:260244
short stride length J:260244
straub tail J:260244
Htttm1Mem/Htttm7Mem
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1 		abnormal blood vessel morphology J:44391
abnormal brain ventricle morphology J:44391
abnormal cerebellum development J:44391
abnormal cerebral aqueduct morphology J:44391
abnormal ear position J:44391
abnormal ear shape J:44391
abnormal embryonic/fetal subventricular zone morphology J:44391
abnormal forebrain morphology J:44391
abnormal head morphology J:44391
abnormal hippocampus morphology J:44391
abnormal midbrain morphology J:44391
abnormal nervous system tract morphology J:44391
abnormal olfactory bulb morphology J:44391
abnormal striatum morphology J:44391
abnormal telencephalon morphology J:44391
abnormal thalamus morphology J:44391
absent hippocampal fimbria J:44391
dilated lateral ventricle J:44391
domed cranium J:44391
exencephaly J:44391
lethality throughout fetal growth and development, incomplete penetrance J:44391
perinatal lethality, complete penetrance J:44391
thick skin J:44391
Htttm1Mfc/Htttm1Mfc
involves: 129S1/Sv * C57BL/6 		abnormal brain morphology J:85298
abnormal gait J:85298
abnormal locomotor activation J:141673
abnormal motor capabilities/coordination/movement J:85298
abnormal olfactory system morphology J:85298
decreased body weight J:141673
decreased locomotor activity J:85298, J:141673
decreased vertical activity J:141673
hyperactivity J:141673
increased grooming behavior J:141673
increased locomotor activity J:85298
increased vertical activity J:85298
short stride length J:85298
Htttm1Szi/Htttm1Szi
either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * MF1) 		abnormal amniotic cavity morphology J:29267
abnormal egg cylinder morphology J:29267
abnormal embryonic tissue morphology J:29267
abnormal extraembryonic tissue morphology J:29267
abnormal Reichert's membrane morphology J:29267
abnormal visceral endoderm morphology J:29267
decreased egg cylinder size J:29267
disorganized embryonic tissue J:29267
disorganized extraembryonic tissue J:29267
embryonic growth arrest J:29267
embryonic lethality, complete penetrance J:29267
increased embryonic epiblast cell apoptosis J:29267
increased embryonic tissue cell apoptosis J:29267
increased Reichert's membrane thickness J:29267
small amniotic cavity J:29267
Htttm1Szi/Htttm2Szi
Tg(Camk2a-cre)1Szi/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA 		abnormal seminiferous tubule morphology J:65520
astrocytosis J:65520
decreased body size J:65520
decreased locomotor activity J:65520
gliosis J:65520
impaired coordination J:65520
limb grasping J:65520
neurodegeneration J:65520
oligozoospermia J:65520
premature death J:65520
reduced male fertility J:65520
small testis J:65520
tremors J:65520
Htttm1Szi/Htttm2Szi
Tg(Camk2a-cre)2Szi/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * CBA 		abnormal brain internal capsule morphology J:65520
abnormal cerebral cortex morphology J:65520
abnormal seminiferous tubule morphology J:65520
abnormal striatum morphology J:65520
astrocytosis J:65520
decreased body size J:65520
decreased locomotor activity J:65520
gliosis J:65520
hydrocephaly J:65520
impaired coordination J:65520
limb grasping J:65520
neurodegeneration J:65520
oligozoospermia J:65520
premature death J:65520
reduced male fertility J:65520
small testis J:65520
tremors J:65520
Htttm2.1Pfs/Htt+
involves: 129X1/SvJ * C57BL/6 		decreased brain size J:54906
increased aggression towards mice J:54906
Htttm2Detl/Htt+
B6J.129P2-Htttm2Detl 		abnormal myelination J:220868
abnormal oligodendrocyte physiology J:220868
abnormal striatum morphology J:220868
brain atrophy J:220868
decreased myelin sheath thickness J:220868
decreased neocortex volume J:220868
decreased oligodendrocyte number J:220868
dysmyelination J:220868
impaired coordination J:220868
increased taurine level J:220868
microgliosis J:220868
neuronal intranuclear inclusions J:220868
weight loss J:220868
Htttm2Detl/Htt+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal behavior J:123681
abnormal dorsal striatum morphology J:123681
abnormal gait J:67074, J:123681
abnormal motor capabilities/coordination/movement J:67074
abnormal motor coordination/balance J:67074
abnormal ventral striatum morphology J:123681
decreased body size J:67074
decreased locomotor activity J:67074
enhanced coordination J:123681
gliosis J:67074
normal homeostasis/metabolism phenotype J:67074
impaired balance J:123681
impaired limb coordination J:67074
limb grasping J:67074
normal nervous system phenotype J:67074
neuron degeneration J:67074
premature death J:67074
short stride length J:123681
Htttm2Detl/Htttm2Detl
involves: 129P2/OlaHsd * C57BL/6J 		abnormal behavior J:123681
abnormal dorsal striatum morphology J:123681
abnormal gait J:67074, J:123681
abnormal motor capabilities/coordination/movement J:67074, J:123681
abnormal motor coordination/balance J:67074
abnormal neuron morphology J:123681
abnormal striatum morphology J:123681
abnormal ventral striatum morphology J:123681
decreased body size J:67074
decreased locomotor activity J:67074, J:123681
gliosis J:67074
normal homeostasis/metabolism phenotype J:67074
impaired balance J:123681
impaired coordination J:123681
impaired limb coordination J:67074
limb grasping J:67074, J:123681
normal nervous system phenotype J:67074
neuron degeneration J:67074
neuronal intranuclear inclusions J:67074
short stride length J:123681
tonic-clonic seizures J:67074, J:123681
tremors J:123681
weight loss J:123681
Htttm2Mem/Htttm2Mem
involves: 129S1/Sv * 129X1/SvJ * CD-1 		normal nervous system phenotype J:99425
Htttm3Mem/Htttm3Mem
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal nervous system phenotype J:99425
Htttm3Mem/Htttm3Mem
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1 		no abnormal phenotype detected J:44391
Htttm4Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal medium spiny neuron morphology J:60937
abnormal striatum morphology J:60937
neuronal intranuclear inclusions J:60937
Htttm4Mem/Htttm4Mem
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal cerebral cortex morphology J:111237
abnormal medium spiny neuron morphology J:60937
abnormal nervous system physiology J:99425
abnormal striatum morphology J:111237
limb grasping J:99425
neuronal intranuclear inclusions J:60937
Htttm4Szi/Htttm4Szi
involves: 129S1/Sv 		no abnormal phenotype detected J:111323
Htttm4Szi/Htttm4Szi
Tg(Hsp70-1-cre)1Arge/0
involves: 129S1/Sv * C57BL/6J * CBA 		abnormal embryonic tissue morphology J:111323
absent somites J:111323
embryonic growth retardation J:111323
embryonic lethality between somite formation and embryo turning, complete penetrance J:111323
Htttm4Szi/Htttm5Szi
involves: 129S1/Sv 		no abnormal phenotype detected J:111323
Htttm4Szi/Htttm5Szi
Tg(Hsp70-1-cre)1Arge/0
involves: 129S1/Sv * C57BL/6J * CBA 		abnormal embryonic tissue morphology J:111323
absent somites J:111323
embryonic growth retardation J:111323
embryonic lethality between somite formation and embryo turning, complete penetrance J:111323
Htttm5Detl/Htt+
involves: C57BL/6 		abnormal gait J:250587
abnormal motor learning J:250587
abnormal striatum morphology J:250587
normal behavior/neurological phenotype J:250587
decreased grip strength J:250587
decreased locomotor activity J:250587
hunched posture J:250587
impaired coordination J:250587
increased thigmotaxis J:250587
long stride length J:250587
prenatal lethality, incomplete penetrance J:250587
weight loss J:250587
Htttm5Detl/Htttm5Detl
involves: C57BL/6 		prenatal lethality, complete penetrance J:250587
Htttm5Mem/Htt+
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal medium spiny neuron morphology J:60937
abnormal striatum morphology J:60937
neuronal intranuclear inclusions J:60937
Htttm5Mem/Htttm5Mem
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal behavior J:99425
abnormal cerebral cortex morphology J:111237
abnormal medium spiny neuron morphology J:60937
abnormal nervous system physiology J:99425
abnormal striatum morphology J:60937, J:111237
decreased locomotor activity J:99425
limb grasping J:99425
neuronal intranuclear inclusions J:60937
tremors J:99425
Htttm5Mem/Htttm5Mem
STOCK Htttm5Mem/J 		abnormal motor coordination/balance J:185262
normal behavior/neurological phenotype J:185262
decreased body weight J:185262
normal nervous system phenotype J:185262
Htttm6Mem/Htttm6Mem
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal motor capabilities/coordination/movement J:72915
decreased body size J:72915
Htttm6Mem/Htttm8Mem
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal brain ventricle morphology J:72915
abnormal gait J:72915
abnormal locomotor coordination J:72915
abnormal motor capabilities/coordination/movement J:72915
bradykinesia J:72915
decreased body size J:72915
decreased body weight J:72915
enlarged lateral ventricles J:72915
enlarged third ventricle J:72915
increased susceptibility to malignant hyperthermia J:72915
limb grasping J:72915
normal nervous system phenotype J:72915
paralysis J:72915
premature death J:72915
seizures J:72915
tremors J:72915
Htttm7Mem/Htttm7Mem
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * CD-1 		abnormal anterior commissure morphology J:44391
abnormal cerebral aqueduct morphology J:44391
abnormal cerebral cortex morphology J:44391
abnormal cranium morphology J:44391
abnormal ear shape J:44391
abnormal forebrain morphology J:44391
abnormal lateral ventricle morphology J:44391
abnormal midbrain morphology J:44391
abnormal nervous system tract morphology J:44391
abnormal postnatal subventricular zone morphology J:44391
abnormal striatum morphology J:44391
abnormal telencephalon morphology J:44391
abnormal thalamus morphology J:44391
dilated lateral ventricle J:44391
enlarged cerebral aqueduct J:44391
lowered ear position J:44391
neonatal lethality, complete penetrance J:44391
perinatal lethality, incomplete penetrance J:44391
thick skin J:44391
Htttm8Mem/Htttm8Mem
involves: 129S1/Sv * 129X1/SvJ 		preweaning lethality, complete penetrance J:72915
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory