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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hbegf
heparin-binding EGF-like growth factor
MGI:96070
57 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hbegftm1.1Mek/Hbegf+
B6.Cg-Hbegftm1.1Mek 		abnormal cardiovascular system physiology J:161948
Hbegftm1.1Mek/Hbegf+
involves: C57BL/6 * C57BL/6J * CBA 		no abnormal phenotype detected J:82728
Hbegftm1.1Mek/Hbegftm1.1Mek
B6.Cg-Hbegftm1.1Mek 		abnormal atrioventricular valve morphology J:161948
abnormal cardiovascular system physiology J:161948
abnormal heart ventricle outflow tract morphology J:161948
Hbegftm1.1Mek/Hbegftm1.1Mek
involves: C57BL/6 * C57BL/6J * CBA 		abnormal atrioventricular valve morphology J:82728
abnormal semilunar valve morphology J:82728
decreased heart ventricle muscle contractility J:82728
dilated heart left ventricle J:82728
dilated heart right ventricle J:82728
dilated heart ventricle J:82728
enlarged aortic valve J:82728
enlarged atrioventricular valve J:82728
enlarged heart J:82728
enlarged mitral valve J:82728
enlarged pulmonary valve J:82728
enlarged semilunar valve J:82728
enlarged tricuspid valve J:82728
increased myocardial fiber size J:82728
postnatal lethality, incomplete penetrance J:82728
premature death J:82728
thick aortic valve J:82728
thick mitral valve J:82728
thick pulmonary valve J:82728
thick tricuspid valve J:82728
Hbegftm1Dcl/Hbegftm1Dcl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal atrioventricular valve development J:83820
abnormal pulmonary alveolus morphology J:83820
abnormal pulmonary valve development J:83820
abnormal type II pneumocyte morphology J:83820
aortic valve stenosis J:83820
atrioventricular valve stenosis J:83820
decreased heart ventricle muscle contractility J:83820
dilated aorta J:83820
ectopic cartilage J:83820
enlarged aortic valve J:83820
enlarged atrioventricular valve J:83820
enlarged heart J:83820
enlarged pulmonary valve J:83820
enlarged semilunar valve J:83820
impaired lung alveolus development J:83820
increased heart weight J:83820
postnatal lethality J:83820
premature death J:83820
pulmonary hypoplasia J:83820
pulmonary valve stenosis J:83820
semilunar valve stenosis J:83820
Hbegftm1Hhar/Hbegftm1Hhar
Tg(Six3-cre)69Frty/0
involves: C57BL/6 * CBA * DBA/2 		abnormal behavioral response to xenobiotic J:154094
abnormal cerebral cortex pyramidal cell morphology J:154094
abnormal social investigation J:154094
abnormal spatial reference memory J:154094
decreased prepulse inhibition J:154094
hyperactivity J:154094
increased locomotor activity J:154094
Hbegftm1Mek/Hbegftm1Mek
involves: C57BL/6 * C57BL/6J * CBA 		no abnormal phenotype detected J:82728
Hbegftm2Mek/Hbegftm2Mek
B6.Cg-Hbegftm2Mek 		abnormal atrioventricular valve morphology J:161948
abnormal heart ventricle outflow tract morphology J:161948
Hbegftm2Mek/Hbegftm2Mek
involves: 129/Sv * C57BL/6 * CBA 		abnormal cardiovascular system morphology J:86547
abnormal cardiovascular system physiology J:86547
abnormal heart size J:86547
abnormal heart valve morphology J:86547
cardiac fibrosis J:86547
decreased cardiac muscle contractility J:86547
decreased heart left ventricle muscle contractility J:86547
dilated cardiomyopathy J:86547
enlarged atrioventricular valve J:86547
enlarged heart J:86547
enlarged semilunar valve J:86547
premature death J:86547
thin myocardium J:86547
Hbegftm3Mek/Hbegf+
involves: 129/Sv * C57BL/6 * CBA 		abnormal myocardial fiber morphology J:86547
cardiac hypertrophy J:86547
decreased body size J:86547
perinatal lethality, incomplete penetrance J:86547
thick epidermis J:86547
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory