Hesx1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hesx1
homeobox gene expressed in ES cells
MGI:96071

56 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0 involves: 129S/SvEv * C57BL/6 * SJL	exencephaly	J:135132
Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor⁺ Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb involves: 129S/SvEv * C57BL/6 * SJL	abnormal eye morphology	J:135132
	postnatal lethality, incomplete penetrance	J:135132
Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb} Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb involves: 129S/SvEv * C57BL/6 * SJL	abnormal eye morphology	J:135132
	anophthalmia	J:135132
	microphthalmia	J:135132
	normal mortality/aging	J:135132
Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb}/Gt(ROSA)26Sor^{tm1(Hesx1)Jpmb} Tmem163^{Tg(ACTB-cre)2Mrt}/0 involves: 129S/SvEv * C57BL/6 * SJL	exencephaly	J:135132
Hesx1^em1(IMPC)J/Hesx1^em1(IMPC)J C57BL/6NJ-Hesx1^em1(IMPC)J/Mmjax	abnormal facial morphology	J:211773
	abnormal head shape	J:211773
	anophthalmia	J:211773
	cleft palate	J:211773
	facial cleft	J:211773
	preweaning lethality, complete penetrance	J:211773
Hesx1^tm1(cre)Jpmb/Hesx1⁺ involves: 129S/SvEv	microphthalmia	J:181005
Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb B6.129S-Hesx1^tm1(cre)Jpmb	abnormal eye development	J:135132
	abnormal telencephalon development	J:135132
	anophthalmia	J:135132
	microphthalmia	J:135132
	perinatal lethality, complete penetrance	J:135132
Hesx1^tm1(cre)Jpmb/Hesx1^tm1(cre)Jpmb involves: 129S/SvEv	abnormal anterior eye segment morphology	J:181005
	anophthalmia	J:181005
	microphthalmia	J:181005
	small embryonic telencephalon	J:181005
Hesx1^tm1(cre)Jpmb/Hesx1^tm1Icar involves: 129P2/OlaHsd * 129S/SvEv	abnormal anterior eye segment morphology	J:181005
	anophthalmia	J:181005
	microphthalmia	J:181005
	small embryonic telencephalon	J:181005
Hesx1^tm1Icar/Hesx1⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal craniofacial morphology	J:47920
	abnormal eye morphology	J:47920
	abnormal forebrain morphology	J:47920
	abnormal nose morphology	J:47920
Hesx1^tm1Icar/Hesx1^tm1Icar involves: 129P2/OlaHsd	abnormal forebrain development	J:181005
	anophthalmia	J:181005
	microphthalmia	J:181005
	small embryonic telencephalon	J:181005
Hesx1^tm1Icar/Hesx1^tm1Icar involves: 129P2/OlaHsd * C57BL/6	abnormal craniofacial morphology	J:47920
	abnormal eye morphology	J:47920
	abnormal forebrain development	J:47920
	abnormal frontonasal prominence morphology	J:142649
	abnormal hypothalamus morphology	J:47920
	abnormal midbrain-hindbrain boundary development	J:135132
	abnormal nasal cavity morphology	J:47920
	abnormal nasal pit morphology	J:47920
	abnormal nasal placode morphology	J:47920
	abnormal olfactory epithelium morphology	J:47920
	abnormal optic cup morphology	J:47920
	abnormal optic vesicle formation	J:47920
	abnormal septum pellucidum morphology	J:47920
	abnormal telencephalon development	J:47920
	abnormal telencephalon morphology	J:47920, J:135132
	absent anterior commissure	J:47920
	absent corpus callosum	J:47920
	absent hippocampal commissure	J:47920
	absent otic vesicle	J:47920
	absent pituitary infundibular stalk	J:47920
	absent Rathke's pouch	J:47920
	anophthalmia	J:47920, J:142649
	bifurcated Rathke's pouch	J:47920
	decreased embryonic neuroepithelium thickness	J:47920
	decreased forebrain size	J:47920, J:135132
	enophthalmos	J:47920
	microcephaly	J:47920
	microphthalmia	J:47920
	neonatal lethality, incomplete penetrance	J:47920
	olfactory bulb hypoplasia	J:47920
	postnatal lethality, incomplete penetrance	J:47920
	short snout	J:47920
	small adenohypophysis	J:47920
	small embryonic telencephalon	J:47920, J:142649
	small vomeronasal organ	J:47920
Hesx1^tm1Icar/Hesx1^tm2Jpmb involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N	abnormal telencephalon development	J:142649
	anophthalmia	J:142649
	microphthalmia	J:142649
Hesx1^tm1Icar/Hesx1^tm3Jpmb involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N	abnormal forebrain development	J:142649
	abnormal forebrain morphology	J:142649
Hesx1^tm2Jpmb/Hesx1^tm2Jpmb involves: 129S/SvEv * C57BL/6J * FVB/N	abnormal adenohypophysis morphology	J:142649
	abnormal craniofacial morphology	J:142649
	abnormal eye morphology	J:142649
	anophthalmia	J:142649
	ectopic pituitary gland	J:142649
	microphthalmia	J:142649
Hesx1^tm3Jpmb/Hesx1^tm3Jpmb involves: 129S/SvEv * C57BL/6J * FVB/N	abnormal adenohypophysis morphology	J:142649
	abnormal anterior commissure morphology	J:142649
	abnormal corpus callosum morphology	J:142649
	abnormal dorsal telencephalic commissure morphology	J:142649
	abnormal forebrain morphology	J:142649
	abnormal frontonasal prominence morphology	J:142649
	abnormal pituitary gland morphology	J:142649
	abnormal Rathke's pouch development	J:142649
	abnormal telencephalon morphology	J:142649
	absent anterior commissure	J:142649
	absent frontonasal prominence	J:142649
	anophthalmia	J:142649
	decreased forebrain size	J:142649
	ectopic adenohypophysis	J:142649
	ectopic pituitary gland	J:142649
	microphthalmia	J:142649
	postnatal lethality, incomplete penetrance	J:142649
	small embryonic telencephalon	J:142649
Hesx1^tm4.1Jpmb/Hesx1^tm4.1Jpmb involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL	abnormal forebrain development	J:181005
	anophthalmia	J:181005
	microphthalmia	J:181005
	small embryonic telencephalon	J:181005

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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