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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nrg1
neuregulin 1
MGI:96083
11 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6 		abnormal muscle spindle morphology J:199150
decreased muscle spindle number J:199150
Bace1tm1Psa/Bace1tm1Psa
Tg(Thy1-Nrg1*I)1Kan/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 		decreased muscle spindle number J:199150
normal nervous system phenotype J:199150
Erbb2tm1Cbm/Erbb2+
Nrg1tm1Cbm/Nrg1+
involves: 129P2/OlaHsd 		abnormal myelination J:90038
abnormal nerve conduction J:90038
Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+
involves: 129P2/OlaHsd 		abnormal myelination J:90038
abnormal nerve conduction J:90038
Nrg1tm1Cbm/Nrg1tm3Cbm
Isl2tm1Arbr/Isl2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J 		abnormal motor neuron innervation pattern J:69623
abnormal motor neuron morphology J:69623
abnormal nervous system development J:69623
abnormal neuromuscular synapse morphology J:69623
absent Schwann cells J:69623
neonatal lethality, incomplete penetrance J:69623
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory