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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hhex
hematopoietically expressed homeobox
MGI:96086
73 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hhextm1Cwb/Hhextm1Cwb
involves: 129X1/SvJ * C57BL/6J 		abnormal atrioventricular cushion morphology J:93580
abnormal atrioventricular valve morphology J:93580
abnormal blood vessel morphology J:93580
abnormal cardiac epithelial to mesenchymal transition J:93580
abnormal conotruncal ridge morphology J:93580
abnormal forebrain development J:93580
abnormal liver development J:93580
abnormal myocardial trabeculae morphology J:93580
abnormal thyroid gland development J:93580
abnormal vasculogenesis J:93580
absent liver J:93580
conotruncal ridge hyperplasia J:93580
decreased forebrain size J:93580
decreased heart right ventricle size J:93580
double outlet right ventricle J:93580
edema J:93580
embryonic lethality during organogenesis, complete penetrance J:93580
heart right ventricle outflow tract stenosis J:93580
increased atrioventricular cushion size J:93580
pericardial edema J:93580
thin myocardium compact layer J:93580
thin ventricular wall J:93580
vascular smooth muscle hypoplasia J:93580
ventricular septal defect J:93580
Hhextm1Cwb/Hhextm2Cwb
Tg(Alb1-cre)1Khk/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal bile duct development J:124126
abnormal liver morphology J:124126
liver cyst J:124126
Hhextm1Cwb/Hhextm2Cwb
Tg(Foxa3-cre)1Khk/?
involves: 129X1/SvJ * C57BL/6 * DBA * SJL 		abnormal extrahepatic bile duct morphology J:124126
abnormal hepatic duct morphology J:124126
abnormal intrahepatic bile duct morphology J:124126
abnormal liver morphology J:124126
absent gallbladder J:124126
biliary cyst J:124126
liver cyst J:124126
liver hypoplasia J:124126
prenatal lethality, complete penetrance J:124126
Hhextm1Jomb/Hhextm1Jomb
involves: 129P2/OlaHsd * C57BL/6 		abnormal embryo development J:149792
prenatal lethality, complete penetrance J:149792
Hhextm1Ngu/Hhextm1Ngu
involves: 129/Sv * C57BL/6 		abnormal hepatocyte morphology J:65105
abnormal liver bud morphology J:65105
abnormal liver development J:65105
abnormal monocyte differentiation J:65105
embryonic lethality during organogenesis, complete penetrance J:65105
impaired hematopoiesis J:65105
Hhextm1Rbe/Hhextm1Rbe
B6.129P2-Hhextm1Rbe 		abnormal thyroid gland development J:95017
Hhextm1Rbe/Hhextm1Rbe
involves: 129P2/OlaHsd * C57BL/6 		abnormal anterior definitive endoderm morphology J:62027
abnormal first pharyngeal arch morphology J:62027
abnormal forebrain development J:62027
abnormal hepatic diverticulum morphology J:62027
abnormal hepatoblast migration J:62027
abnormal medial ganglionic eminence morphology J:62027
abnormal nasal placode morphology J:62027
abnormal optic stalk morphology J:62027
abnormal optic vesicle formation J:62027
abnormal pericardial cavity morphology J:62027
abnormal telencephalon development J:62027
abnormal thyroid gland development J:62027
abnormal thyroid gland morphology J:62027
absent embryonic telencephalon J:62027
absent forebrain J:62027
absent liver J:62027
absent nasal placodes J:62027
absent Rathke's pouch J:62027
anophthalmia J:62027
decreased forebrain size J:62027
embryonic growth retardation J:62027
embryonic lethality during organogenesis, incomplete penetrance J:62027
fused first pharyngeal arch J:62027
lethality throughout fetal growth and development, complete penetrance J:62027
rostral body truncation J:62027
small embryonic telencephalon J:62027
Hhextm2Cwb/Hhextm2Cwb
Tg(Alb1-cre)1Khk/?
involves: 129S1/Sv * C57BL/6 * SJL 		liver cyst J:124126
Tg(ITGAL-Hhex)2Hro/0
C3HeB/FeJ-Tg(ITGAL-Hhex)2Hro 		abnormal common myeloid progenitor cell morphology J:80777
abnormal definitive hematopoiesis J:80777
abnormal double-negative T cell morphology J:80777
abnormal thymus corticomedullary boundary morphology J:80777
decreased double-positive T cell number J:80777
decreased leukocyte cell number J:80777
decreased lymphocyte cell number J:80777
decreased T cell number J:80777
increased CD8-positive, alpha-beta T cell number J:80777
increased erythroid progenitor cell number J:80777
thymus hypoplasia J:80777
Tg(Lck-Hhex)1Hro/0
C3HeB/FeJ-Tg(Lck-Hhex)1Hro 		abnormal double-negative T cell morphology J:80777
decreased double-positive T cell number J:80777
decreased leukocyte cell number J:80777
decreased lymphocyte cell number J:80777
decreased T cell number J:80777
increased CD8-positive, alpha-beta T cell number J:80777
thymus hyperplasia J:80777
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory