Hmgcl Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hmgcl
3-hydroxy-3-methylglutaryl-Coenzyme A lyase
MGI:96158

14 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hmgcl^tm1Gam/Hmgcl⁺ either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	abnormal hepatocyte morphology	J:52117
Hmgcl^tm1Gam/Hmgcl^tm1Gam either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * CD-1)	abnormal heart morphology	J:52117
	abnormal hepatocyte mitochondrial morphology	J:52117
	abnormal hepatocyte morphology	J:52117
	abnormal placenta morphology	J:52117
	decreased embryo size	J:52117
	embryonic lethality during organogenesis, incomplete penetrance	J:52117
Hmgcl^tm2Gam/Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ B6.Cg-Hmgcl^tm2Gam Speer6-ps1^{Tg(Alb-cre)21Mgn}	abnormal gluconeogenesis	J:204294
	abnormal hepatocyte mitochondrial morphology	J:204294
	abnormal hepatocyte physiology	J:204294
	normal homeostasis/metabolism phenotype	J:204294
	hypoglycemia	J:204294
	increased circulating ammonia level	J:204294
	increased circulating carnitine level	J:204294
	lethargy	J:204294
	premature death	J:204294

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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