About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hmgcr
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
MGI:96159
34 phenotypes from 3 alleles in 2 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Hmgcrem1Bcgen/Hmgcrem1Bcgen
Not Specified 		normal homeostasis/metabolism phenotype J:299971
increased circulating triglyceride level J:299971
Hmgcrtm1Ishi/Hmgcr+
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:86378
Hmgcrtm1Ishi/Hmgcrtm1Ishi
involves: 129S7/SvEvBrd * C57BL/6J 		embryonic lethality, complete penetrance J:86378
Hmgcrtm2Ishi/Hmgcrtm2Ishi
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:201488
Hmgcrtm2Ishi/Hmgcrtm2Ishi
Tg(Alb1-cre)1Dlr/0
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal circulating apolipoprotein level J:201488
abnormal circulating lipoprotein level J:201488
abnormal liver parenchyma morphology J:201488
abnormal liver physiology J:201488
decreased circulating cholesterol level J:201488
decreased circulating LDL cholesterol level J:201488
decreased circulating triglyceride level J:201488
decreased liver cholesterol level J:201488
enlarged liver J:201488
hepatic necrosis J:201488
hypoglycemia J:201488
increased circulating alanine transaminase level J:201488
increased circulating aspartate transaminase level J:201488
increased circulating bilirubin level J:201488
increased circulating cholesterol level J:201488
increased circulating free fatty acids level J:201488
increased circulating LDL cholesterol level J:201488
increased circulating phospholipid level J:201488
increased collagen level J:201488
increased fatty acids level J:201488
increased liver triglyceride level J:201488
increased liver weight J:201488
increased unsaturated fatty acids level J:201488
jaundice J:201488
liver failure J:201488
microvesicular hepatic steatosis J:201488
pale liver J:201488
postnatal lethality, incomplete penetrance J:201488
premature death J:201488
weight loss J:201488
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory