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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hmga1
high mobility group AT-hook 1
MGI:96160
43 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hmga1tm1Afus/Hmga1+
involves: 129S7/SvEvBrd * C57BL/6 		cardiac hypertrophy J:106702
enlarged spleen J:106702
Hmga1tm1Afus/Hmga1tm1Afus
involves: 129S7/SvEvBrd * C57BL/6 		abnormal myocardium layer morphology J:106702
cardiac hypertrophy J:106702
decreased body weight J:106702
enlarged spleen J:106702
heart left ventricle hypertrophy J:106702
increased B cell derived lymphoma incidence J:106702
increased leukemia incidence J:106702
lymphoid hyperplasia J:106702
myeloid hyperplasia J:106702
Hmga1tm1Brun/Hmga1+
Not Specified 		decreased circulating insulin level J:99652
decreased insulin secretion J:99652
impaired glucose tolerance J:99652
increased insulin sensitivity J:99652
insulin resistance J:99652
Hmga1tm1Brun/Hmga1tm1Brun
Not Specified 		abnormal pancreatic islet morphology J:99652
decreased circulating insulin level J:99652
decreased insulin secretion J:99652
impaired glucose tolerance J:99652
increased insulin sensitivity J:99652
insulin resistance J:99652
small pancreatic islets J:99652
Hmga1tm1Cha/Hmga1+
chimera involves: 129S1/Sv * C57BL/6J 		abnormal seminiferous tubule epithelium morphology J:84851
abnormal seminiferous tubule morphology J:84851
abnormal Sertoli cell morphology J:84851
abnormal spermatogenesis J:84851
azoospermia J:84851
decreased male germ cell number J:84851
male infertility J:84851
small epididymis J:84851
small seminiferous tubules J:84851
small testis J:84851
Hmga1tm2b(EUCOMM)Hmgu/Hmga1+
C57BL/6N-Hmga1tm2b(EUCOMM)Hmgu/Bay 		unresponsive to tactile stimuli J:211773
Hmga1tm2b(EUCOMM)Hmgu/Hmga1tm2b(EUCOMM)Hmgu
C57BL/6N-Hmga1tm2b(EUCOMM)Hmgu/Bay 		preweaning lethality, incomplete penetrance J:211773
unresponsive to tactile stimuli J:211773
Tg(H2-K-Hmga1)#Lmsr/0
involves: C57BL/6 * SJL 		abnormal endometrium morphology J:121308
abnormal intestine morphology J:184301
abnormal uterine cervix morphology J:90252
decreased locomotor activity J:90252
female infertility J:121308
increased intestinal mucosa thickness J:184301
increased leukemia incidence J:121308
increased leukocyte cell number J:90252
increased lymphoma incidence J:90252, J:121308
increased T cell acute lymphoblastic leukemia incidence J:90252
increased uterus leiomyoma incidence J:121308
increased uterus tumor incidence J:121308
intestine polyps J:184301
premature death J:90252
rectal prolapse J:90252
visceromegaly J:90252
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory