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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hoxa2
homeobox A2
MGI:96174
94 phenotypes from 12 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Hoxa2)Fmr/Gt(ROSA)26Sor+
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129P2/OlaHsd 		abnormal brain development J:193058
decreased oligodendrocyte progenitor number J:193058
Hoxa2tm1(tetO)Mllo/Hoxa2tm1(tetO)Mllo
involves: 129S1/Sv 		abnormal rhombomere 2 morphology J:80131
abnormal rhombomere 3 morphology J:80131
abnormal rhombomere morphology J:80131
Hoxa2tm1(tetO)Mllo/Hoxa2tm1(tetO)Mllo
involves: 129S1/Sv * C57BL/6J 		abnormal hyoid bone lesser horn morphology J:71951
abnormal incudostapedial joint morphology J:71951
abnormal middle ear ossicle morphology J:71951
abnormal stapes morphology J:71951
abnormal styloid process morphology J:71951
abnormal temporal bone squamous part morphology J:71951
abnormal tongue muscle morphology J:71951
absent stapedial artery J:71951
bifid tongue J:71951
normal hearing/vestibular/ear phenotype J:71951
neonatal lethality, complete penetrance J:71951
normal nervous system phenotype J:71951
small malleus processus brevis J:71951
Hoxa2tm1(tetO)Mllo/Hoxa2tm1Grid
involves: 129S1/Sv * C57BL/6J 		abnormal facial nerve morphology J:71951
abnormal hyoid bone lesser horn morphology J:71951
abnormal malleus morphology J:71951
abnormal middle ear ossicle morphology J:71951
abnormal outer ear morphology J:71951
abnormal stapedial artery morphology J:71951
abnormal temporal bone squamous part morphology J:71951
abnormal tongue muscle morphology J:71951
abnormal tympanic ring morphology J:71951
absent oval window J:71951
absent stapes J:71951
absent styloid process J:71951
cleft palate J:71951
normal nervous system phenotype J:71951
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
involves: 129/Sv * C57BL/6 * SJL 		no abnormal phenotype detected J:75130, J:80131
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:102845
abnormal gonial bone morphology J:102845
abnormal hyoid bone morphology J:102845
abnormal incus morphology J:102845
abnormal malleus morphology J:102845
abnormal Meckel's cartilage morphology J:102845
absent outer ear J:102845
absent stapes J:102845
absent styloid process J:102845
duplicated tympanic ring J:102845
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal cochlear VIII nucleus morphology J:197162
lethality throughout fetal growth and development J:197162
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
Tg(CAG-cre/ERT2)F34Fmr/0
involves: 129 * CD-1 		abnormal brain development J:193058
increased oligodendrocyte progenitor number J:193058
Hoxa2tm1.1Fmr/Hoxa2tm1.1Fmr
Tg(CAG-cre/ERT2)F34Fmr/0
involves: 129/Sv * C57BL/6 * CD-1 		abnormal craniofacial bone morphology J:102845
abnormal gonial bone morphology J:102845
abnormal middle ear morphology J:102845
abnormal stapes morphology J:102845
abnormal styloid process morphology J:102845
absent hyoid bone lesser horns J:102845
absent outer ear J:102845
perinatal lethality, complete penetrance J:102845
Hoxa2tm1.2Fmr/Hoxa2tm1.2Fmr
involves: 129/Sv * C57BL/6 * SJL 		abnormal behavior J:75130
abnormal craniofacial morphology J:75130
abnormal ear morphology J:75130
abnormal nervous system morphology J:75130
abnormal skeleton morphology J:75130
neonatal lethality, complete penetrance J:75130
Hoxa2tm1b(EUCOMM)Wtsi/Hoxa2+
C57BL/6N-Hoxa2tm1b(EUCOMM)Wtsi/Ieg 		abnormal auditory brainstem response J:211773
abnormal gait J:211773
abnormal snout morphology J:211773
decreased circulating creatinine level J:211773
decreased prepulse inhibition J:211773
decreased respiratory quotient J:211773
improved glucose tolerance J:211773
Hoxa2tm1b(EUCOMM)Wtsi/Hoxa2tm1b(EUCOMM)Wtsi
C57BL/6N-Hoxa2tm1b(EUCOMM)Wtsi/Ieg 		preweaning lethality, complete penetrance J:211773
Hoxa2tm1Fmr/Hoxa2+
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:80131
Hoxa2tm1Fmr/Hoxa2tm1Fmr
involves: 129/Sv * C57BL/6 		abnormal hyoid bone lesser horn morphology J:80131
abnormal rhombomere 2 morphology J:80131
abnormal stapes morphology J:80131
abnormal styloid process morphology J:80131
lethality at weaning, complete penetrance J:80131
postnatal growth retardation J:80131
Hoxa2tm1Grid/Hoxa2+
involves: 129S1/Sv 		abnormal malleus morphology J:71951
abnormal retrotympanic process morphology J:71951
abnormal rhombomere boundary morphology J:71951
abnormal styloid process morphology J:71951
Hoxa2tm1Grid/Hoxa2tm1Grid
involves: 129S1/Sv 		abnormal basisphenoid bone morphology J:71951
abnormal external auditory canal morphology J:30826
abnormal facial nerve morphology J:71951
abnormal gonial bone morphology J:71951
abnormal rhombomere boundary morphology J:71951
abnormal stapedial artery morphology J:71951
abnormal temporal bone squamous part morphology J:71951
absent outer ear J:71951
aphagia J:71951
decreased rhombomere 3 size J:71951
duplicated tympanic ring J:30826
neonatal lethality, complete penetrance J:71951
Hoxa2tm1Grid/Hoxa2tm1Grid
involves: 129S1/Sv * C57BL/6J 		abnormal basioccipital bone morphology J:16389
abnormal facial nerve morphology J:16389
abnormal glossopharyngeal nerve morphology J:16389
abnormal hyoid bone morphology J:16389
abnormal Meckel's cartilage morphology J:16389
abnormal middle ear ossicle morphology J:16389
abnormal outer ear morphology J:16389
abnormal palatal shelf fusion at midline J:151467
abnormal secondary palate development J:151467, J:316149
abnormal styloid process morphology J:16389
abnormal temporal bone morphology J:16389
abnormal tubotympanic recess morphology J:16389
abnormal tympanic ring morphology J:16389
abnormal vagus nerve morphology J:16389
absent stapes J:16389
cleft secondary palate J:16389
failure of palatal shelf elevation J:151467, J:316149
meteorism J:16389
neonatal lethality, complete penetrance J:16389
normal nervous system phenotype J:16389
palatal shelves fail to meet at midline J:151467
persistence of medial edge epithelium during palatal shelf fusion J:316149
Hoxa2tm1Grid/Hoxa2tm1Grid
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * DBA/2 		abnormal incus morphology J:100238
abnormal malleus morphology J:100238
abnormal otic capsule morphology J:100238
Hoxa2tm1Ipc/Hoxa2tm1.1Fmr
Tg(CAG-cre/ERT2)F34Fmr/0
involves: 129/Sv * 129S2/SvPas * C57BL/6 * CD-1 		abnormal craniofacial bone morphology J:102845
small ears J:102845
Hoxa2tm1Ipc/Hoxa2tm1Ipc
involves: 129S2/SvPas 		abnormal basioccipital bone morphology J:16388
abnormal cartilage development J:16388
abnormal craniofacial bone morphology J:102845
abnormal facial motor nucleus morphology J:16388
abnormal facial nerve morphology J:16388
abnormal gonial bone morphology J:102845
abnormal incus morphology J:16388, J:102845
abnormal malleus morphology J:16388, J:102845
abnormal Meckel's cartilage morphology J:16388, J:102845
abnormal neuron differentiation J:54652
abnormal otic capsule morphology J:16388
abnormal retrotympanic process morphology J:16388
abnormal rhombomere 2 morphology J:54652
abnormal rhombomere 3 morphology J:54652
abnormal scala vestibuli morphology J:16388
abnormal skeleton development J:16388
abnormal stapes morphology J:16388
abnormal suckling behavior J:16388
abnormal temporal bone morphology J:16388
abnormal temporal bone squamous part morphology J:16388
abnormal temporal bone tympanic part morphology J:16388
abnormal tensor tympani muscle morphology J:16388
abnormal tympanic cavity morphology J:16388
abnormal tympanic membrane morphology J:16388
absent hyoid bone lesser horns J:16388, J:102845
absent malleus processus brevis J:16388
absent outer ear J:16388, J:102845
absent stapedius muscle J:16388
absent stapes J:102845
absent stylohyoid muscle J:16388
absent styloid process J:102845
bifid tongue J:16388
cleft secondary palate J:16388
duplicated tympanic ring J:102845
enlarged gonial bone J:16388
increased rhombomere 1 size J:54652
neonatal lethality, complete penetrance J:16388
Hoxa2tm1Mrc/Hoxa2tm1Mrc
involves: 129S1/Sv * 129X1/SvJ 		abnormal basioccipital bone morphology J:58093
abnormal cranium morphology J:58093
abnormal middle ear ossicle morphology J:58093
abnormal styloglossus muscle morphology J:58093
abnormal suckling behavior J:58093
abnormal tongue muscle morphology J:58093
absent outer ear J:58093
cleft secondary palate J:58093
neonatal lethality, complete penetrance J:58093
Hoxa2tm2(cre)Mrc/Hoxa2tm2(cre)Mrc
Not Specified 		decreased sensory neuron number J:88581
Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr
involves: 129S2/SvPas 		abnormal brain development J:193058
increased oligodendrocyte progenitor number J:193058
Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr
involves: 129S2/SvPas * C57BL/6 		normal nervous system phenotype J:197162
Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal behavior J:75129
abnormal craniofacial morphology J:75129
abnormal ear morphology J:75129
abnormal nervous system morphology J:75129
abnormal skeleton morphology J:75129
neonatal lethality, complete penetrance J:75129
Hoxa2tm2Fmr/Hoxa2tm2Fmr
involves: 129S2/SvPas 		abnormal behavior J:75129
abnormal craniofacial morphology J:75129
abnormal ear morphology J:75129
abnormal nervous system morphology J:75129
abnormal skeleton morphology J:75129
neonatal lethality, complete penetrance J:75129
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory