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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hoxa5
homeobox A5
MGI:96177
70 phenotypes from 4 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hoxa5tm1.1Ljea/Hoxa5+
Tg(Sftpc-cre)1Blh/0
involves: 129 * C57BL/6J * DBA/2 * SJL 		abnormal pulmonary alveolar sac morphology J:170336
lung cyst J:170336
Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea
involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J * SJL 		no abnormal phenotype detected J:125040
Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea
Tg(Hoxa5-cre)444CLjea/0
involves: 129/Sv * C57BL/6 * CBA * SJL 		abnormal cervical vertebrae morphology J:207917
abnormal xiphoid process morphology J:207917
normal mortality/aging J:207917
normal respiratory system phenotype J:207917
Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea
Tg(Hoxa5-cre)447BLjea/0
involves: 129/Sv * C57BL/6 * CBA * SJL 		abnormal cervical vertebrae morphology J:207917
abnormal lung development J:207917
abnormal pulmonary alveolus morphology J:207917
abnormal trachea morphology J:207917
abnormal xiphoid process morphology J:207917
increased rib number J:207917
perinatal lethality, incomplete penetrance J:207917
respiratory distress J:207917
Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea
Tg(Sftpc-cre)1Blh/0
involves: 129 * C57BL/6J * DBA/2 * SJL 		abnormal pulmonary alveolar sac morphology J:170336
lung cyst J:170336
Hoxa5tm1.2Ljea/Hoxa5tm1.2Ljea
involves: 129/Sv * C57BL/6 * CBA * SJL 		abnormal cervical vertebrae morphology J:125040
abnormal pulmonary alveolus morphology J:125040
abnormal tracheal cartilage morphology J:125040
atelectasis J:125040
cricoid and tracheal cartilage fusion J:125040
emphysema J:125040
increased respiratory mucosa goblet cell number J:125040
neonatal lethality, incomplete penetrance J:125040
Hoxa5tm1Ljea/Hoxa5tm1Ljea
involves: 129/Sv * C57BL/6J * SJL 		abnormal cervical vertebrae morphology J:125040
abnormal tracheal cartilage morphology J:125040
atelectasis J:125040
cricoid and tracheal cartilage fusion J:125040
neonatal lethality, incomplete penetrance J:125040
Hoxa5tm1Rob/Hoxa5tm1Rob
129S(Cg)-Hoxa5tm1Rob 		abnormal branching involved in lung morphogenesis J:45341
abnormal bronchiole epithelium morphology J:45341
abnormal bronchiole morphology J:45341
abnormal bronchus epithelium morphology J:45341
abnormal cricoid cartilage morphology J:45341
abnormal digestive secretion J:58676
abnormal estrous cycle J:182519
abnormal larynx morphology J:45341
abnormal lung saccule morphology J:45341
abnormal pulmonary acinus morphology J:45341
abnormal thyroid gland development J:84449
abnormal trachea morphology J:45341
abnormal tracheal cartilage morphology J:45341
atelectasis J:45341
cricoid and tracheal cartilage fusion J:45341
cyanosis J:45341
decreased surfactant secretion J:84449
decreased tracheal cartilage ring number J:45341
delayed ear emergence J:84449
delayed eyelid opening J:45341, J:84449
early sexual maturation J:182519
impaired branching involved in respiratory bronchiole morphogenesis J:45341
increased circulating estradiol level J:182519
increased circulating thyroid-stimulating hormone level J:84449
meteorism J:45341
neonatal lethality, incomplete penetrance J:45341
ovary cyst J:182519
postnatal growth retardation J:45341, J:84449
postnatal lethality, incomplete penetrance J:45341
prolonged diestrus J:182519
prolonged estrous cycle J:182519
prolonged metestrus J:182519
respiratory distress J:45341
short estrus J:182519
trachea occlusion J:45341
trachea stenosis J:45341
Hoxa5tm1Rob/Hoxa5tm1Rob
B6.129S(Cg)-Hoxa5tm1Rob 		abnormal cricoid cartilage morphology J:45341
abnormal trachea morphology J:45341
atelectasis J:45341
decreased surfactant secretion J:45341
decreased tracheal cartilage ring number J:45341
delayed eyelid opening J:45341
impaired branching involved in bronchus morphogenesis J:45341
meteorism J:45341
neonatal lethality, incomplete penetrance J:45341
postnatal growth retardation J:45341
postnatal lethality, incomplete penetrance J:45341
thick pulmonary interalveolar septum J:45341
trachea occlusion J:45341
Hoxa5tm1Rob/Hoxa5tm1Rob
involves: 129S/SvEv * C57BL/6 * MF1 		abnormal alveolar macrophage morphology J:113378
abnormal lung weight J:113378
abnormal pulmonary alveolar parenchyma morphology J:113378
abnormal pulmonary alveolus morphology J:113378
abnormal pulmonary elastic fiber morphology J:113378
abnormal pulmonary interalveolar septum morphology J:113378
abnormal respiratory mucosa goblet cell morphology J:113378
abnormal surfactant secretion J:113378
atelectasis J:113378
emphysema J:113378
impaired lung alveolus development J:113378
increased respiratory mucosa goblet cell number J:113378
increased type II pneumocyte number J:113378
lung inflammation J:113378
overexpanded pulmonary alveolus J:113378
Hoxa5tm1Rob/Hoxa5tm1Rob
involves: 129S/SvEv * MF1 		abnormal rib morphology J:15576
abnormal vertebrae morphology J:15576
asymmetric sternocostal joints J:15576
cervical vertebral transformation J:15576
increased rib number J:15576
increased sternebra number J:15576
lumbar vertebral transformation J:15576
postnatal lethality, incomplete penetrance J:15576
rib fusion J:15576
sternebra fusion J:15576
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory