About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hprt1
hypoxanthine phosphoribosyltransferase 1
MGI:96217
297 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Agtr1atm1.1Cof/Agtr1atm1.1Cof
Hprt1tm1(Pck1-cre)Vhh/Hprt1+
involves: 129 * 129P2/OlaHsd 		abnormal renal water reabsorption J:172240
decreased renal glomerular filtration rate J:172240
decreased systemic arterial systolic blood pressure J:172240
Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd 		decreased renin activity J:91837
kidney cyst J:91837
Agtr1atm1Unc/Agtr1atm1Unc
Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd 		decreased urine osmolality J:91837
hypotension J:91837
ApcMin/Apc+
Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/?
involves: 129S7/SvEvBrd * C57BL/6J 		increased intestinal adenoma incidence J:168378
Arnttm1Bra/Arnttm1Bra
Hprt1tm1(Pck1-cre)Vhh/Y
Vhltm1Jae/Vhltm1Jae
involves: 129 * BALB/c * C57BL/6 		normal hematopoietic system phenotype J:97652
hepatic steatosis J:97652
normal neoplasm J:97652
normal renal/urinary system phenotype J:106705
Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		normal liver/biliary system phenotype J:285667
Dicer1tm1Bdh/Dicer1tm1Bdh
Hprt1tm1(Pck1-cre)Vhh/Y
involves: 129 * 129P2/OlaHsd 		decreased susceptibility to kidney reperfusion injury J:185838
normal renal/urinary system phenotype J:185838
Dysfprmd/Dysfprmd
Hprt1tm2(CAG-Myof)Isrd/Y
involves: 129 * A/J * C57BL/6 		dystrophic muscle J:187293
normal homeostasis/metabolism phenotype J:187293
normal muscle phenotype J:187293
Dysfprmd/Dysfprmd
Hprt1tm2(CAG-Myof)Isrd/Hprt1tm2(CAG-Myof)Isrd
involves: 129 * A/J * C57BL/6 		dystrophic muscle J:187293
normal homeostasis/metabolism phenotype J:187293
normal muscle phenotype J:187293
Ext1tm1Vcs/Ext1+
Hprt1tm1(CAG-cre)Mnn/Hprt1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:157599
Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+
involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J 		increased oligodendrocyte number J:291492
increased oligodendrocyte progenitor number J:291492
Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/?
involves: 129S7/SvEvBrd * C57BL/6J 		normal digestive/alimentary phenotype J:168378
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Hprt1tm6(CAG-fat-1)Geno/Hprt1tm6(CAG-fat-1)Geno
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal fatty acids level J:213660
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Hprt1tm1(Ins2-HBEGF)Herr/Y
Tg(Gcg-rtTA)#Herr/0
Tg(tetO-cre)1Jaw/0
involves: 129X1/SvJ * C57BL/6 		abnormal pancreatic alpha cell differentiation J:159291
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Hprt1tm1(Ins2-HBEGF)Herr/Y
Tg(Ins2-cre/ERT)1Dam/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal pancreatic islet morphology J:159291
normal endocrine/exocrine gland phenotype J:159291
Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+
Hprt1tm1(sb-Onco-Array)Peli/Hprt1+
involves: 129S7/SvEvBrd 		decreased birth body size J:166283
increased hemangioma incidence J:166283
increased hemangiosarcoma incidence J:166283
increased lung adenocarcinoma incidence J:166283
increased lung adenoma incidence J:166283
increased lymphoma incidence J:166283
increased medulloblastoma incidence J:166283
increased rhabdomyosarcoma incidence J:166283
increased skin squamous cell carcinoma incidence J:166283
increased tumor incidence J:166283
perinatal lethality, incomplete penetrance J:166283
postnatal growth retardation J:166283
postnatal lethality, incomplete penetrance J:166283
premature death J:166283
Gt(ROSA)26Sortm1(sb11)Njen/Gt(ROSA)26Sor+
Hprt1tm1(sb-Onco-Array)Peli/Y
involves: 129S7/SvEvBrd 		decreased birth body size J:166283
increased hemangioma incidence J:166283
increased hemangiosarcoma incidence J:166283
increased lung adenocarcinoma incidence J:166283
increased lung adenoma incidence J:166283
increased lymphoma incidence J:166283
increased medulloblastoma incidence J:166283
increased rhabdomyosarcoma incidence J:166283
increased skin squamous cell carcinoma incidence J:166283
increased tumor incidence J:166283
perinatal lethality, incomplete penetrance J:166283
postnatal growth retardation J:166283
postnatal lethality, incomplete penetrance J:166283
premature death J:166283
Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr
involves: 129S/SvEv * 129S/SvEvBrd 		abnormal dorsal root ganglion morphology J:114455
abnormal enzyme/coenzyme level J:114455
abnormal somatic sensory system morphology J:114455
abnormal sympathetic ganglion morphology J:114455
adrenal medulla hyperplasia J:114455
prenatal lethality, incomplete penetrance J:114455
Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr
involves: 129S/SvEv * 129S/SvEvBrd 		abnormal somatic sensory system morphology J:114455
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprt1tm1(Pbsn*-cre/ERT2)Jir/Hprt1+
involves: 129P2/OlaHsd * 129S4/SvJaeSor 		no abnormal phenotype detected J:144541
Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Hprt1tm1(CAG-cre)Mnn/Hprt1tm1(CAG-cre)Mnn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		prenatal lethality, complete penetrance J:120967
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Hprt1tm1(CAG-cre)Mnn/Hprt1tm1(CAG-cre)Mnn
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal embryonic tissue morphology J:120967
prenatal lethality, complete penetrance J:120967
Hif1atm3Rsjo/Hif1atm3Rsjo
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprt1tm1(Pck1-cre)Vhh/Y
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ 		abnormal cell differentiation J:130751
decreased susceptibility to injury J:130751
kidney inflammation J:130751
renal fibrosis J:130751
Hif1atm3Rsjo/Hif1atm3Rsjo
Hprt1tm1(Pck1-cre)Vhh/Y
Vhltm1Jae/Vhltm1Jae
involves: 129 * BALB/c * C57BL/6 		abnormal kidney morphology J:106705
abnormal kidney vasculature morphology J:106705
abnormal vasodilation J:97652
hepatic steatosis J:97652
increased hemoglobin content J:97652
increased hepatic hemangioma incidence J:97652
increased vascular endothelial cell number J:97652
kidney cyst J:106705
kidney inflammation J:106705
polycythemia J:97652
Hprt1b-m3/Y
Impdh1tm1Bmi/Impdh1tm1Bmi
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal lymphopoiesis J:85443
decreased cytotoxic T cell cytolysis J:85443
decreased interleukin-4 secretion J:85443
decreased splenocyte proliferation J:85443
decreased T cell proliferation J:85443
Hprt1b-m3/Y
Impdh2tm1Bmi/Impdh2+
involves: 129P2/OlaHsd 		abnormal cytotoxic T cell physiology J:86045
abnormal lymphocyte cell number J:86045
Hprt1tm1(ACTB-Epor)Unc/Y
involves: 129P2/OlaHsd 		abnormal definitive hematopoiesis J:81859
normal hematopoietic system phenotype J:81859
Hprt1tm1(ACTB-Epor)Unc/Hprt1tm1(ACTB-Epor)Unc
involves: 129P2/OlaHsd 		abnormal definitive hematopoiesis J:81859
normal hematopoietic system phenotype J:81859
Hprt1tm1(ACTB-Opa1)Lsc/Y
involves: 129 * C57BL/6 * C57BL/6J 		abnormal mitochondrial crista morphology J:214492
abnormal mitochondrial physiology J:214492
decreased susceptibility to injury J:214492
normal growth/size/body region phenotype J:214492
Hprt1tm1(AGT)Asku/Y
Tg(REN)64071Sig/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating angiotensinogen level J:143791
abnormal protein level J:143791
increased circulating angiotensin II level J:143791
increased systemic arterial systolic blood pressure J:143791
Hprt1tm1(AGT)Sig/Hprt1tm1(AGT)Sig
Tg(hAGT)2041Sig/?
involves: 129P2/OlaHsd * C57BL/6 * SJL/J 		normal cardiovascular system phenotype J:81310
Hprt1tm1(APOA5)Lap/Y
involves: 129P2/OlaHsd * C57BL/6J 		normal homeostasis/metabolism phenotype J:145098
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * FVB/N 		abnormal translation J:285667
increased pancreatic ductal adenocarcinoma incidence J:285667
premature death J:285667
Hprt1tm1(CAG-cre)Mnn/Hprt1+
Ptpn11tm1Ckq/Ptpn11+
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J 		abnormal craniofacial development J:177285
abnormal heart tube morphology J:177285
embryonic growth retardation J:177285
embryonic lethality during organogenesis, complete penetrance J:177285
Hprt1tm1(CAG-Glra3*)Jcme/Y
Pvalbtm1(cre)Arbr/Pvalb+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal CNS synaptic transmission J:207981
abnormal nervous system electrophysiology J:207981
absent long-term depression J:207981
normal behavior/neurological phenotype J:207981
increased anxiety-related response J:207981
Hprt1tm1(CAG-Glra3*)Jcme/Y
Tg(Camk2a-cre)2Gsc/0
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal nervous system electrophysiology J:207981
abnormal object recognition memory J:207981
abnormal spatial reference memory J:207981
abnormal spatial working memory J:207981
abnormal synaptic glutamate release J:207981
increased susceptibility to pharmacologically induced seizures J:207981
normal nervous system phenotype J:207981
Hprt1tm1(CAG-Gys1*)Jjg/?
Myl1tm1(cre)Sjb/Myl1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal cellular respiration J:244440
abnormal response to exercise J:244440
decreased aerobic running capacity J:244440
impaired exercise endurance J:244440
increased skeletal muscle glycogen level J:244440
Hprt1tm1(CAG-Gys1*)Jjg/?
Tg(Nes-cre)1Kag/?
involves: 129P2/OlaHsd 		impaired autophagy J:210491
increased brain glycogen level J:210491
Hprt1tm1(CAG-mCherry/Villin)Syr/?
Vil1tm1Syr/Vil1tm1Syr
Tg(Vil1-cre/ERT2)23Syr/0
involves: C57BL/6 		normal homeostasis/metabolism phenotype J:196199
Hprt1tm1(CAG-NRIP1)Vcls/Hprt1+
involves: 129 * C57BL/6 		abnormal enterocyte proliferation J:211324
abnormal Paneth cell morphology J:211324
abnormal small intestine morphology J:211324
decreased enterocyte apoptosis J:211324
Hprt1tm1(CAG-NRIP1)Vcls/Y
involves: 129 * C57BL/6 		abnormal enterocyte proliferation J:211324
abnormal Paneth cell morphology J:211324
abnormal small intestine morphology J:211324
decreased enterocyte apoptosis J:211324
Hprt1tm1(CAG-Sox9,-EGFP)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+
involves: 129/Sv * 129S1/SvImJ * NMRI 		abnormal ureter morphology J:166547
abnormal ureter smooth muscle morphology J:166547
Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 		abnormal T cell activation J:148747
Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 		normal immune system phenotype J:148747
Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 		abnormal T cell activation J:148747
Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 		normal immune system phenotype J:148747
Hprt1tm1(Camk2a-APP*Swe*Lon,-MAPT*P301L*R406W)Geno/Hprt1+
Tg(PSEN1)5Dbo/0
involves: 129P2/OlaHsd 		abnormal brain wave pattern J:180977
abnormal glucose homeostasis J:180977
abnormal learning/memory/conditioning J:180977
abnormal long-term potentiation J:180977
abnormal motor coordination/balance J:180977
abnormal spatial reference memory J:180977
abnormal spatial working memory J:180977
decreased paired-pulse facilitation J:180977
fragmentation of sleep/wake states J:180977
hyperactivity J:180977
impaired short-term object recognition memory J:180977
normal nervous system phenotype J:180977
Hprt1tm1(CUX1)Anep/Hprt1+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB) 		abnormal hematopoietic system morphology/development J:113393
abnormal hematopoietic system physiology J:113393
abnormal liver morphology J:113393
abnormal lung morphology J:113393
abnormal spleen white pulp morphology J:113393
abnormal splenic cell ratio J:113393
anemia J:113393
decreased B cell number J:113393
decreased erythrocyte cell number J:113393
decreased hematocrit J:113393
decreased mean corpuscular hemoglobin concentration J:113393
enlarged lymph nodes J:113393
enlarged spleen J:113393
increased leukocyte cell number J:113393
increased neutrophil cell number J:113393
myeloid hyperplasia J:113393
spleen hyperplasia J:113393
Hprt1tm1(CUX1)Anep/Hprt1+
FVB.129P2-Hprt1tm1(CUX1)Anep 		abnormal branching of the mammary ductal tree J:152682
increased mammary adenocarcinoma incidence J:152682
increased mammary gland tumor incidence J:152682
Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:91837
Hprt1tm1(H1-RNAi:Tmsb4x)Prri/Hprt1+
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * SJL 		abnormal blood vessel morphology J:195902
embryonic lethality during organogenesis, incomplete penetrance J:195902
hemopericardium J:195902
internal hemorrhage J:195902
intracranial hemorrhage J:195902
lethality throughout fetal growth and development, incomplete penetrance J:195902
Hprt1tm1(Ins2-HBEGF)Herr/Y
involves: 129 * C57BL/6 		abnormal pancreatic beta cell physiology J:159291
abnormal pancreatic islet morphology J:159291
decreased insulin secretion J:159291
decreased pancreatic beta cell mass J:159291
decreased pancreatic beta cell number J:159291
hyperglycemia J:159291
increased insulin secretion J:159291
increased pancreatic beta cell mass J:159291
ketoacidosis J:159291
polydipsia J:159291
polyuria J:159291
premature death J:159291
weight loss J:159291
Hprt1tm1(Ins2-HBEGF)Herr/Hprt1tm1(Ins2-HBEGF)Herr
involves: 129 * C57BL/6 		hyperglycemia J:159291
Hprt1tm1(Ins2-HBEGF)Herr/Y
Tg(Gcg-HBEGF)#Herr/0
involves: 129 * C57BL/6 		normal endocrine/exocrine gland phenotype J:159291
Hprt1tm1(MAPT)Dph/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal autophagy J:263643
abnormal hippocampus morphology J:263643
abnormal hippocampus physiology J:263643
abnormal skeletal muscle fiber morphology J:263643
normal behavior/neurological phenotype J:263643
decreased grip strength J:263643
normal growth/size/body region phenotype J:263643
impaired coordination J:263643
impaired spatial learning J:263643
kyphosis J:263643
limb grasping J:263643
paresis J:263643
premature death J:263643
skeletal muscle fiber degeneration J:263643
Hprt1tm1(Nphs1-CMIP)Dsah/Hprt1+
B6.Cg-Hprt1tm1(Nphs1-CMIP)Dsah 		abnormal podocyte morphology J:185411
abnormal podocyte slit diaphragm morphology J:185411
absent podocyte slit diaphragm J:185411
albuminuria J:185411
expanded mesangial matrix J:185411
glomerulosclerosis J:185411
increased mesangial cell number J:185411
increased urine protein level J:185411
podocyte foot process effacement J:185411
Hprt1tm1(Pbsn*-cre/ERT2)Jir/Y
Ptentm2Mak/Ptentm2Mak
involves: 129P2/OlaHsd * C57BL/6 		increased prostate gland adenocarcinoma incidence J:144357
increased prostate intraepithelial neoplasia incidence J:144357
Hprt1tm1(Pck1-cre)Vhh/Hprt1+
Tg(CAG-lacZ,-Miox)#Ysk/0
involves: 129P2/OlaHsd * C57BL/6J 		increased blood urea nitrogen level J:266834
increased circulating creatinine level J:266834
increased renal tubule apoptosis J:266834
increased susceptibility to injury J:266834
oxidative stress J:266834
Hprt1tm1(Pck1-cre)Vhh/Y
Vhltm1Jae/Vhltm1Jae
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 		abnormal kidney morphology J:106705
abnormal kidney vasculature morphology J:106705
abnormal vasodilation J:97652
hepatic steatosis J:97652
increased hemoglobin content J:97652
increased hepatic hemangioma incidence J:97652
increased vascular endothelial cell number J:97652
kidney cyst J:106705
kidney inflammation J:106705
polycythemia J:97652
Hprt1tm1(Rcan1)Zyga/Hprt1+
B6.129P2-Hprt1tm1(Rcan1)Zyga 		abnormal megakaryocyte progenitor cell morphology J:197570
decreased tumor growth/size J:150286
decreased vascular endothelial cell proliferation J:150286
increased megakaryocyte cell number J:197570
thrombocytosis J:197570
Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
involves: 129S4/SvJae * C57BL/6 		normal renal/urinary system phenotype J:206088
Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(Nphs1-rtTA*3G)8Jhm/0
involves: 129S4/SvJae * C57BL/6 		increased urine protein level J:206088
normal renal/urinary system phenotype J:206088
Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(NPHS2-rtTA2*M2)1Jbk/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		increased urine protein level J:206088
podocyte foot process effacement J:206088
Hprt1tm1(tetO-Runx1,-EGFP)Enk/Hprt1+
Sox10tm2(rtTA)Weg/Sox10+
involves: 129P2/OlaHsd 		abnormal skin pigmentation J:165939
decreased birth body size J:165939
hyperresponsive to tactile stimuli J:165939
megacolon J:165939
postnatal lethality, complete penetrance J:165939
small dorsal root ganglion J:165939
Hprt1tm1(UAS-Bmp4)Bhr/Hprt1+
Tg(Wnt1-GAL4)1Rth/0
involves: 129S7/SvEvBrd * C57BL/6 		embryonic growth retardation J:91296
embryonic lethality during organogenesis, incomplete penetrance J:91296
exencephaly J:91296
hemorrhage J:91296
Hprt1tm1(UBC-UBB)Rrk/Hprt1tm1(UBC-UBB)Rrk
Ubctm1Rrk/Ubctm1Rrk
involves: 129 * C57BL/6J 		normal cellular phenotype J:122574
decreased embryo size J:122574
normal liver/biliary system phenotype J:122574
perinatal lethality, complete penetrance J:122574
Hprt1tm1(UBC-UBB)Rrk/Y
Ubctm1Rrk/Ubctm1Rrk
involves: 129 * C57BL/6J 		normal cellular phenotype J:122574
decreased embryo size J:122574
normal liver/biliary system phenotype J:122574
perinatal lethality, complete penetrance J:122574
Hprt1tm1.1(CAG-DLL1*,-Venus)Gos/Y
involves: 129P2/OlaHsd * C57BL/6J * CD-1 		no abnormal phenotype detected J:209193
Hprt1tm1.1(CAG-DLL1*,-Venus)Gos/Hprt1tm1.1(CAG-DLL1*,-Venus)Gos
involves: 129P2/OlaHsd * C57BL/6J * CD-1 		no abnormal phenotype detected J:209193
Hprt1tm1.1(CAG-Smpd1)Jhkh/Hprt1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal ceramide level J:199833
abnormal depression-related behavior J:199833
abnormal neuron differentiation J:199833
abnormal physiological response to xenobiotic J:199833
Hprt1tm1Detl/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal brain morphology J:44728
abnormal gait J:44728
abnormal motor capabilities/coordination/movement J:44728
ataxia J:44728
convulsive seizures J:44728
decreased exploration in new environment J:44728
decreased vertical activity J:44728
hepatic steatosis J:44728
impaired coordination J:44728
increased body weight J:44728
jerky movement J:44728
limb grasping J:44728
neuronal intranuclear inclusions J:44728
premature death J:44728
seizures J:44728
testicular atrophy J:44728
tremors J:44728
Hprt1tm1Detl/Hprt1tm1Detl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal brain morphology J:44728
abnormal gait J:44728
abnormal motor capabilities/coordination/movement J:44728
ataxia J:44728
convulsive seizures J:44728
decreased exploration in new environment J:44728
decreased vertical activity J:44728
hepatic steatosis J:44728
impaired coordination J:44728
jerky movement J:44728
limb grasping J:44728
neuronal intranuclear inclusions J:44728
premature death J:44728
seizures J:44728
tremors J:44728
Hprt1tm1Dhm/Y
involves: 129P2/OlaHsd 		abnormal cardiac muscle relaxation J:106044
abnormal myocardial fiber physiology J:106044
cardiac hypertrophy J:106044
decreased cardiac muscle contractility J:106044
decreased heart ventricle muscle contractility J:91410
increased heart weight J:91410
Hprt1tm1Dhm/Hprt1tm1Dhm
involves: 129P2/OlaHsd 		abnormal cardiac muscle relaxation J:106044
abnormal myocardial fiber physiology J:106044
cardiac hypertrophy J:106044
decreased cardiac muscle contractility J:106044
decreased heart ventricle muscle contractility J:91410
increased heart weight J:91410
Hprt1tm1Dhm/Hprt1tm1Dhm
Plntm1Egk/Plntm1Egk
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal cardiac muscle relaxation J:106044
abnormal myocardial fiber physiology J:106044
increased cardiac muscle contractility J:106044
Hprt1tm1Dhm/Y
Plntm1Egk/Plntm1Egk
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal cardiac muscle relaxation J:106044
abnormal myocardial fiber physiology J:106044
increased cardiac muscle contractility J:106044
Hprt1tm1Dwm/Y
involves: 129P2/OlaHsd 		phenotypic reversion J:161048
Hprt1tm2(AGT)Asku/Y
Tg(REN)64071Sig/?
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating angiotensinogen level J:143791
abnormal protein level J:143791
increased circulating angiotensin II level J:143791
increased systemic arterial systolic blood pressure J:143791
Hprt1tm2(AGT)Sig/Y
involves: 129P2/OlaHsd * C57BL/6J 		increased systemic arterial blood pressure J:81515
Hprt1tm2(AGT)Sig/Hprt1tm2(AGT)Sig
involves: 129P2/OlaHsd * C57BL/6J 		increased systemic arterial blood pressure J:81515
Hprt1tm2(AGT)Sig/Hprt1tm2(AGT)Sig
Tg(hAGT)2041Sig/?
involves: 129P2/OlaHsd * C57BL/6 * SJL/J 		increased heart weight J:81310
Hprt1tm2(AGT)Sig/Y
Tg(hAGT)2041Sig/?
involves: 129P2/OlaHsd * C57BL/6 * SJL/J 		increased systemic arterial blood pressure J:81310
Hprt1tm2(APOA5)Lap/Y
involves: 129P2/OlaHsd * C57BL/6J 		normal homeostasis/metabolism phenotype J:145098
Hprt1tm2(CAG-mCherry/Villin*)Syr/?
Vil1tm1Syr/Vil1tm1Syr
Tg(Vil1-cre/ERT2)23Syr/0
involves: C57BL/6 		impaired wound healing J:196199
Hprt1tm2(CAG-Myof)Isrd/Y
involves: 129 * C57BL/6 		normal muscle phenotype J:187293
Hprt1tm2(CAG-Myof)Isrd/Hprt1tm2(CAG-Myof)Isrd
involves: 129 * C57BL/6 		normal muscle phenotype J:187293
Hprt1tm2(CAG-Ppp1r3c)Jjg/?
Not Specified 		impaired autophagy J:210491
increased brain glycogen level J:210491
Hprt1tm2(CAG-Ppp1r3c)Jjg/?
Nhlrc1tm1(KOMP)Vlcg/Nhlrc1tm1(KOMP)Vlcg
involves: C57BL/6NTac 		impaired autophagy J:210491
increased brain glycogen level J:210491
Hprt1tm2(CAG-TBX2,-EGFP)Akis/Hprt1+
Tg(Myh6-cre)2182Mds/0
involves: 129 * FVB/N * NMRI 		abnormal heart development J:181526
Hprt1tm2(CUX1)Anep/Hprt1+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB) 		normal immune system phenotype J:113393
Hprt1tm2(CUX1)Anep/Hprt1+
FVB.129P2-Hprt1tm2(CUX1)Anep 		normal endocrine/exocrine gland phenotype J:152682
increased mammary adenocarcinoma incidence J:152682
increased mammary gland tumor incidence J:152682
Hprt1tm2(Pgk1-Pac/TK)Brd/Y
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:99258
Hprt1tm2(Pgk1-Pac/TK)Brd/Y
involves: 129S7/SvEvBrd * C57BL/6J 		normal reproductive system phenotype J:99558
Hprt1tm2(Pgk1-Pac/TK)Brd/Hprt1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal aortic arch morphology J:130481
abnormal aortic valve morphology J:130481
abnormal cardiac outflow tract development J:130481
abnormal cardiovascular development J:130481
abnormal craniofacial morphology J:130481
abnormal heart morphology J:130481
abnormal heart right ventricle morphology J:130481
abnormal heart valve morphology J:130481
abnormal mitral valve morphology J:130481
abnormal neural crest cell morphology J:130481
abnormal pharyngeal arch mesenchyme morphology J:130481
congestive heart failure J:130481
decreased embryo size J:130481
double outlet right ventricle J:130481
edema J:130481
embryonic lethality during organogenesis, incomplete penetrance J:130481
enlarged heart J:130481
heart right ventricle outflow tract stenosis J:130481
interrupted aortic arch J:130481
interrupted aortic arch, type b J:130481
interrupted aortic arch, type c J:130481
overriding aortic valve J:130481
pericardial effusion J:130481
persistent truncus arteriosus J:130481
pulmonary valve stenosis J:130481
retroesophageal right subclavian artery J:130481
right aortic arch J:130481
transposition of great arteries J:130481
ventricular septal defect J:130481
Hprt1tm2(Pgk1-Pac/TK)Brd/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal aortic arch morphology J:130481
abnormal aortic valve morphology J:130481
abnormal cardiac outflow tract development J:130481
abnormal cardiovascular development J:130481
abnormal craniofacial morphology J:130481
abnormal heart morphology J:130481
abnormal heart right ventricle morphology J:130481
abnormal heart valve morphology J:130481
abnormal mitral valve morphology J:130481
abnormal neural crest cell morphology J:130481
abnormal pharyngeal arch mesenchyme morphology J:130481
congestive heart failure J:130481
decreased embryo size J:130481
double outlet right ventricle J:130481
edema J:130481
embryonic lethality during organogenesis, incomplete penetrance J:130481
enlarged heart J:130481
heart right ventricle outflow tract stenosis J:130481
interrupted aortic arch J:130481
interrupted aortic arch, type b J:130481
interrupted aortic arch, type c J:130481
overriding aortic valve J:130481
pericardial effusion J:130481
persistent truncus arteriosus J:130481
pulmonary valve stenosis J:130481
retroesophageal right subclavian artery J:130481
right aortic arch J:130481
transposition of great arteries J:130481
ventricular septal defect J:130481
Hprt1tm2(UAS-Bmp4)Bhr/Hprt1+
Tg(Wnt1-GAL4)1Rth/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal blood vessel morphology J:91296
abnormal eye morphology J:91296
embryonic growth retardation J:91296
embryonic lethality during organogenesis, incomplete penetrance J:91296
exencephaly J:91296
hemorrhage J:91296
Hprt1tm2.1(CAG-DLL1*,-Venus)Gos/Y
involves: 129P2/OlaHsd * C57BL/6J * CD-1 		no abnormal phenotype detected J:209193
Hprt1tm2.1(CAG-DLL1*,-Venus)Gos/Hprt1tm2.1(CAG-DLL1*,-Venus)Gos
involves: 129P2/OlaHsd * C57BL/6J * CD-1 		no abnormal phenotype detected J:209193
Hprt1tm2Brd/Hprt1+
Myo7a4626SB/Myo7a4626SB
involves: 129S7/SvEvBrd * BALB/cRl * C3H * C57BL/6J * CBA/Ca 		normal hearing/vestibular/ear phenotype J:132633
Hprt1tm3(APOA5)Lap/Hprt1tm3(APOA5)Lap
involves: 129P2/OlaHsd * C57BL/6J 		normal homeostasis/metabolism phenotype J:145098
Hprt1tm3(CAG-Tbx18,-Venus)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+
involves: 129S1/SvImJ * NMRI 		normal cardiovascular system phenotype J:210076
postnatal lethality, complete penetrance J:210076
Hprt1tm3.1(CAG-DLL1*,-Venus)Gos/Y
involves: 129P2/OlaHsd * C57BL/6J * CD-1 		no abnormal phenotype detected J:209193
Hprt1tm3.1(CAG-DLL1*,-Venus)Gos/Hprt1tm3.1(CAG-DLL1*,-Venus)Gos
involves: 129P2/OlaHsd * C57BL/6J * CD-1 		no abnormal phenotype detected J:209193
Hprt1tm3Brd/Hprt1+
Myo7a4626SB/Myo7a4626SB
involves: 129S7/SvEvBrd * BALB/cRl * C3H * C57BL/6J * CBA/Ca 		normal hearing/vestibular/ear phenotype J:132633
Hprt1tm4(CAG-Tbx18*,-Venus)Akis/Y
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Tbx18tm4(cre)Akis/Tbx18+
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI 		abnormal epicardium development J:210076
Hprt1tm4(CAG-Tbx18*,-Venus)Akis/Y
Tbx18tm4(cre)Akis/Tbx18+
involves: 129S1/SvImJ * NMRI 		abnormal pericardium morphology J:210076
abnormal sinus venosus morphology J:210076
normal cardiovascular system phenotype J:210076
decreased fetal cardiomyocyte proliferation J:210076
heart hypoplasia J:210076
lethality throughout fetal growth and development, complete penetrance J:210076
thin ventricle myocardium compact layer J:210076
Hprt1tm4(Tek-IGF1R)Geno/Y
B6.129P2-Hprt1tm4(Tek-IGF1R)Geno 		abnormal nitric oxide homeostasis J:208523
abnormal vascular endothelial cell migration J:208523
abnormal vascular endothelial cell physiology J:208523
abnormal vascular wound healing J:208523
normal cardiovascular system phenotype J:208523
normal homeostasis/metabolism phenotype J:208523
increased vasoconstriction J:208523
Hprt1tm5(Camk2a-BACE1)Geno/Y
B6.129P2-Hprt1tm5(Camk2a-BACE1)Geno 		abnormal habituation to a new environment J:215577
abnormal motor coordination/balance J:215577
abnormal nervous system morphology J:215577
abnormal spatial reference memory J:215577
astrocytosis J:215577
decreased anxiety-related response J:215577
decreased body weight J:215577
decreased locomotor activity J:215577
impaired social transmission of food preference J:215577
impaired spatial working memory J:215577
neurodegeneration J:215577
neuronal intranuclear inclusions J:215577
short stride length J:215577
normal taste/olfaction phenotype J:215577
Hprt1tm5(Camk2a-BACE1)Geno/Hprt1tm5(Camk2a-BACE1)Geno
B6.129P2-Hprt1tm5(Camk2a-BACE1)Geno 		abnormal habituation to a new environment J:215577
abnormal motor coordination/balance J:215577
abnormal nervous system morphology J:215577
abnormal spatial reference memory J:215577
astrocytosis J:215577
decreased anxiety-related response J:215577
decreased body weight J:215577
decreased locomotor activity J:215577
impaired social transmission of food preference J:215577
impaired spatial working memory J:215577
neurodegeneration J:215577
neuronal intranuclear inclusions J:215577
short stride length J:215577
normal taste/olfaction phenotype J:215577
Hprt1tm6(CAG-fat-1)Geno/Y
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal fatty acids level J:213660
Hprt1tm86(NR2E1,bEMS223)Ems/Y
B6.Cg-Hprt1tm86(NR2E1,bEMS223)Ems 		abnormal neuronal precursor proliferation J:183689
normal cardiovascular system phenotype J:183689
normal nervous system phenotype J:183689
normal vision/eye phenotype J:183689
Hprt1tm86(NR2E1,bEMS223)Ems/Y
Nr2e1frc/Nr2e1frc
involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 		abnormal cerebral hemisphere morphology J:183689
abnormal neuronal precursor proliferation J:183689
normal cardiovascular system phenotype J:183689
small olfactory bulb J:183689
normal vision/eye phenotype J:183689
Mcoln3tm1.2Hels/Mcoln3tm1.2Hels
Hprt1tm1(CAG-cre)Mnn/?
involves: 129X1/SvJ * C57BL/6 * FVB/N 		normal hearing/vestibular/ear phenotype J:167711
normal reproductive system phenotype J:167711
Mioxtm1Ysk/Mioxtm1Ysk
Hprt1tm1(Pck1-cre)Vhh/Hprt1+
B6.129-Mioxtm1Ysk Hprt1tm1(Pck1-cre)Vhh 		decreased susceptibility to injury J:266834
decreased susceptibility to weight loss J:266834
Pdss2tm1Dalg/Pdss2tm1Dalg
Hprt1tm1(Pck1-cre)Vhh/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal homeostasis/metabolism phenotype J:136670
normal renal/urinary system phenotype J:136670
Phox2btm1Rth/Phox2b+
Hprt1tm1(CAG-cre)Mnn/?
involves: 129 * 129S1/Sv * C57BL/6 		abnormal facial nerve morphology J:331513
abnormal innervation J:331513
abnormal locus ceruleus morphology J:331513
abnormal nervous system electrophysiology J:331513
abnormal neuron morphology J:331513
abnormal trigeminal V mesencephalic nucleus morphology J:331513
abnormal vagus nerve morphology J:331513
cyanosis J:331513
perinatal lethality, complete penetrance J:331513
respiratory failure J:331513
Porcntm1.1Vdv/Porcn+
Hprt1tm1(CAG-cre)Mnn/Hprt1+
involves: 129S/Sv * C57BL/6J 		abnormal ventral body wall morphology J:186934
caudal body truncation J:186934
embryonic growth retardation J:186934
embryonic lethality during organogenesis, incomplete penetrance J:186934
open neural tube J:186934
prenatal lethality, complete penetrance J:186934
Thrbtm1Mkni/Thrb+
Hprt1tm1(TG-cre)1Sasr/Y
involves: 129/Sv * C57BL/6 		decreased thyroid gland weight J:208718
Thrbtm1Mkni/Thrbtm1Mkni
Hprt1tm1(TG-cre)1Sasr/Y
involves: 129/Sv * C57BL/6 		abnormal thyroid hormone level J:208718
decreased circulating thyroid-stimulating hormone level J:208718
decreased thyroid gland weight J:208718
normal growth/size/body region phenotype J:208718
increased circulating levels of thyroid hormone J:208718
increased circulating thyroxine level J:208718
increased thyroxine level J:208718
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory