Hras Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hras
Harvey rat sarcoma virus oncogene
MGI:96224

11 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cdkn2a^tm2Brn/Cdkn2a^tm2Brn Tg(Tyr-cre/ERT,-Hras1,-Trap1a)10BJvde/0 involves: C57BL/6 FVB/N	increased classified tumor incidence	J:107175
	increased cutaneous melanoma incidence	J:107175
	increased neurofibrosarcoma incidence	J:107175
Hras^tm1Esn/Hras^tm1Esn Nras^tm1Rak/Nras^tm1Rak involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6N	no abnormal phenotype detected	J:67374
Hras^tm1Grnt/Hras^tm1Grnt Syngap1^tm1Grnt/Syngap1⁺ involves: 129P2/OlaHsd * MF1	reduced long-term potentiation	J:98903
Hras^tm1Jaf/Hras^tm1Jaf Nf2^tm2Gth/Nf2^tm2Gth Tg(TPO-cre)1Shk/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr	increased thyroid tumor incidence	J:231492
Hras^tm1Jaf/Hras^tm1Jaf Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(TPO-cre)1Shk/0 involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr	increased thyroid tumor incidence	J:231492
Hras^tm1Jaf/Hras^tm1Jaf Trp53^tm1Brn/Trp53^tm1Brn Tg(TPO-cre)1Shk/0 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr	increased thyroid tumor incidence	J:231492
Hras^tm1Mok/Hras⁺ Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras⁺ Nras^tm1Mok/Nras⁺ Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras^tm1Mok either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	embryonic lethality during organogenesis, complete penetrance	J:135610
Hras^tm1Mok/Hras^tm1Mok Kras^tm1Mok/Kras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)7Mok/0 either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	no abnormal phenotype detected	J:135610
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras⁺ involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)	prenatal lethality, incomplete penetrance	J:135610
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok involves: 129S/SvEv * C57BL/6 * DBA/2	chylous ascites	J:159024
Hras^tm1Mok/Hras^tm1Mok Nras^tm1Mok/Nras^tm1Mok Tg(HRAS)2Jic/0 involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	normal homeostasis/metabolism phenotype	J:159024
Tg(Tyr-cre/ERT,-Hras1*,-Trap1a)10BJvde/0 involves: FVB/N	increased tumor incidence	J:107175

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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