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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hspg2
perlecan (heparan sulfate proteoglycan 2)
MGI:96257
130 phenotypes from 7 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Hspg2tm1.1Rdgr/Hspg2tm1.1Rdgr
involves: 129S1/Sv * 129X1/SvJ 		abnormal long bone epiphyseal plate proliferative zone J:121855
abnormal long bone hypertrophic chondrocyte zone J:121855
normal skeleton phenotype J:121855
Hspg2tm1.1Soni/Hspg2tm1.1Soni
involves: 129S/SvEv * C57BL/6 		abnormal behavior J:139975
abnormal endplate potential J:139975
abnormal joint morphology J:139975
abnormal miniature endplate potential J:139975
abnormal muscle electrophysiology J:139975
abnormal neuromuscular synapse morphology J:139975
abnormal skeletal muscle fiber morphology J:139975
abnormal skeletal muscle fiber type ratio J:139975
centrally nucleated skeletal muscle fibers J:139975
chondrodystrophy J:139975
decreased body length J:139975
decreased body weight J:139975
delayed eyelid opening J:139975
increased variability of skeletal muscle fiber size J:139975
premature death J:139975
Hspg2tm1Nid/Hspg2tm1Nid
involves: 129X1/SvJ * C57BL/6 		abnormal bone ossification J:67299
abnormal cartilage development J:67299
abnormal cartilage morphology J:67299
abnormal craniofacial morphology J:67299
abnormal cranium morphology J:67299
abnormal forelimb morphology J:67299
abnormal hindlimb morphology J:67299
abnormal long bone hypertrophic chondrocyte zone J:67299
abnormal neuromuscular synapse morphology J:74542
abnormal skeleton morphology J:67299
abnormal vertebral body morphology J:67299
decreased chondrocyte proliferation J:67299
delayed bone ossification J:67299
disorganized long bone epiphyseal plate J:67299
disproportionate dwarf J:67299
domed cranium J:67299
embryonic lethality during organogenesis, incomplete penetrance J:67299
exencephaly J:67299
perinatal lethality, incomplete penetrance J:67299
respiratory failure J:67299
short limbs J:67299
short mandible J:67299
short snout J:67299
wide cranial sutures J:67299
Hspg2tm1Rdgr/Hspg2tm1Rdgr
involves: 129S1/Sv * 129X1/SvJ 		abnormal bone marrow morphology J:121855
abnormal bone ossification J:121855
abnormal bone structure J:121855
abnormal cell physiology J:121855
abnormal femur head morphology J:121855
abnormal femur neck morphology J:121855
abnormal gait J:121855
abnormal humerus morphology J:121855
abnormal locomotor coordination J:121855
abnormal long bone epiphyseal plate morphology J:121855
abnormal long bone epiphysis morphology J:121855
abnormal long bone morphology J:121855
abnormal muscle morphology J:121855
abnormal osteoclast morphology J:121855
abnormal pelvic girdle bone morphology J:121855
abnormal skeleton morphology J:121855
abnormal sternum morphology J:121855
abnormal trabecular bone morphology J:121855
abnormal vertebral column morphology J:121855
bowed humerus J:121855
decreased body length J:121855
decreased body weight J:121855
decreased cranium height J:121855
decreased length of long bones J:121855
delayed bone ossification J:121855
flat face J:121855
increased diameter of humerus J:121855
increased diameter of long bones J:121855
increased osteoclast cell number J:121855
increased width of hypertrophic chondrocyte zone J:121855
microphthalmia J:121855
osteoarthritis J:121855
short femur J:121855
short femur neck J:121855
skeletal muscle hyperplasia J:121855
Hspg2tm1Ref/Hspg2tm1Ref
involves: 129S1/Sv * 129X1/SvJ 		abnormal aortic valve morphology J:80720
abnormal ascending aorta and coronary artery attachment J:107987
abnormal bone marrow cavity morphology J:58700
abnormal brain morphology J:58700
abnormal cardiac outflow tract development J:80720
abnormal cardinal vein morphology J:80720
abnormal cartilage development J:84739
abnormal cartilage morphology J:58700
abnormal chest morphology J:84739
abnormal chondrocyte morphology J:58700
abnormal conotruncus septation J:80720
abnormal cranium morphology J:58700
abnormal endochondral bone ossification J:84739
abnormal ethmoid bone morphology J:58700
abnormal heart and great artery attachment J:107987
abnormal inner ear development J:58700
abnormal intervertebral disk development J:84739
abnormal long bone epiphyseal plate morphology J:58700, J:84739
abnormal long bone hypertrophic chondrocyte zone J:58700, J:84739
abnormal long bone metaphysis morphology J:84739
abnormal long bone morphology J:58700, J:84739
abnormal middle ear development J:58700
abnormal myocardium compact layer morphology J:58700
abnormal myocardium layer morphology J:80720
abnormal nervous system morphology J:58700
abnormal occipital bone morphology J:58700
abnormal pericardium morphology J:58700
abnormal pulmonary valve morphology J:80720
abnormal rib morphology J:84739
abnormal semilunar valve morphology J:80720
abnormal skeleton morphology J:58700
abnormal sphenoid bone morphology J:58700
abnormal spine curvature J:58700
abnormal telencephalon morphology J:58700
absent conotruncal ridges J:80720
absent frontal bone J:58700
absent neurocranium J:58700
absent parietal bone J:58700
aneurysm J:58700
chondrodystrophy J:58700, J:84739
cleft palate J:58700
conotruncal ridge hyperplasia J:80720
decreased body length J:84739
decreased bone mineralization J:58700
decreased embryo size J:84739
decreased length of long bones J:58700
dilated liver sinusoidal space J:80720
disorganized long bone epiphyseal plate J:58700
disproportionate dwarf J:58700, J:84739
domed cranium J:58700
embryonic lethality during organogenesis, incomplete penetrance J:58700
enlarged vertebral body J:84739
exencephaly J:58700
hemopericardium J:58700
hemorrhage J:58700
impaired basement membrane formation J:58700
increased compact bone thickness J:58700
intracranial hemorrhage J:58700
irregular heartbeat J:58700
lung hemorrhage J:58700
perinatal lethality, incomplete penetrance J:58700
short limbs J:58700
short mandible J:58700
short nasal bone J:58700
skin hemorrhage J:58700
transposition of great arteries J:80720, J:107987
Hspg2tm1Ref/Hspg2tm1Ref
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal basement membrane morphology J:119018
abnormal radial glial cell endfoot morphology J:119018
exencephaly J:119018
Hspg2tm1Soin/Hspg2tm1Soin
B6.129P2-Hspg2tm1Soin 		normal homeostasis/metabolism phenotype J:167008
Hspg2tm1Soni/Hspg2tm1Soni
involves: 129S/SvEv * C57BL/6 		abnormal behavior J:139975
decreased body weight J:139975
delayed eyelid opening J:139975
normal mortality/aging J:139975
Hspg2tm1Soni/Hspg2tm1Soni
involves: 129S/SvEv * DBA/2J 		abnormal action potential J:183547
abnormal axon morphology J:183547
abnormal internode morphology J:183547
abnormal myelin sheath morphology J:183547
abnormal neuromuscular synapse morphology J:183547
abnormal node of Ranvier morphology J:183547
abnormal paranode morphology J:183547
demyelination J:183547
increased Schwann cell number J:183547
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory