About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
MGI:96273
19 phenotypes from 5 alleles in 7 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Htr1atm1Rhn/Htr1a+
involves: 129S1/Sv 		increased anxiety-related response J:51280
Htr1atm1Rhn/Htr1atm1Rhn
129S6/SvEvTac-Htr1atm1Rhn 		abnormal serotonin level J:65662, J:70686
increased dopamine level J:65662
increased noradrenaline level J:65662
normal nervous system phenotype J:65662, J:70686
Htr1atm1Rhn/Htr1atm1Rhn
involves: 129S1/Sv 		behavioral despair J:51280
increased anxiety-related response J:51280
Htr1atm1Rhn/Htr1atm1Rhn
involves: 129S/SvEv * 129S1/Sv 		abnormal nervous system physiology J:167655
increased anxiety-related response J:167655
Htr1atm1Tct/Htr1a+
involves: 129X1/SvJ * C57BL/6J 		behavioral despair J:51565
increased anxiety-related response J:51565
Htr1atm1Tct/Htr1atm1Tct
involves: 129X1/SvJ * C57BL/6J 		normal behavior/neurological phenotype J:51565
behavioral despair J:51565
increased anxiety-related response J:51565
increased thigmotaxis J:51565
normal nervous system phenotype J:51565
Htr1atm1Toth/Htr1a+
involves: 129P2/OlaHsd * Black Swiss 		increased anxiety-related response J:49752
Htr1atm1Toth/Htr1atm1Toth
involves: 129P2/OlaHsd * Black Swiss 		abnormal spatial learning J:66581
decreased paired-pulse facilitation J:61579, J:66581
increased anxiety-related response J:49752, J:61579
increased locomotor activity J:49752
increased susceptibility to pharmacologically induced seizures J:66581
Htr1atm2Rhn/Htr1a+
involves: BALB/c * C57BL/6 		decreased vertical activity J:118885
Htr1atm3.1Rhn/?
Tg(HCRT-tTA)G5Ahky/0
B6.Cg-Htr1atm3.1Rhn Tg(HCRT-tTA)G5Ahky 		abnormal sleep duration J:212974
abnormal sleep pattern J:212974
fragmentation of sleep/wake states J:212974
increased frequency of paradoxical sleep J:212974
increased slow-wave sleep duration J:212974
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory