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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
MGI:96273
19 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Htr1atm1Rhn/Htr1a+
involves: 129S1/Sv 		increased anxiety-related response J:51280
Htr1atm1Rhn/Htr1atm1Rhn
129S6/SvEvTac-Htr1atm1Rhn 		abnormal serotonin level J:65662, J:70686
increased dopamine level J:65662
increased noradrenaline level J:65662
normal nervous system phenotype J:65662, J:70686
Htr1atm1Rhn/Htr1atm1Rhn
involves: 129S1/Sv 		behavioral despair J:51280
increased anxiety-related response J:51280
Htr1atm1Rhn/Htr1atm1Rhn
involves: 129S/SvEv * 129S1/Sv 		abnormal nervous system physiology J:167655
increased anxiety-related response J:167655
Htr1atm1Tct/Htr1a+
involves: 129X1/SvJ * C57BL/6J 		behavioral despair J:51565
increased anxiety-related response J:51565
Htr1atm1Tct/Htr1atm1Tct
involves: 129X1/SvJ * C57BL/6J 		normal behavior/neurological phenotype J:51565
behavioral despair J:51565
increased anxiety-related response J:51565
increased thigmotaxis J:51565
normal nervous system phenotype J:51565
Htr1atm1Toth/Htr1a+
involves: 129P2/OlaHsd * Black Swiss 		increased anxiety-related response J:49752
Htr1atm1Toth/Htr1atm1Toth
involves: 129P2/OlaHsd * Black Swiss 		abnormal spatial learning J:66581
decreased paired-pulse facilitation J:61579, J:66581
increased anxiety-related response J:49752, J:61579
increased locomotor activity J:49752
increased susceptibility to pharmacologically induced seizures J:66581
Htr1atm2Rhn/Htr1a+
involves: BALB/c * C57BL/6 		decreased vertical activity J:118885
Htr1atm3.1Rhn/?
Tg(HCRT-tTA)G5Ahky/0
B6.Cg-Htr1atm3.1Rhn Tg(HCRT-tTA)G5Ahky 		abnormal sleep duration J:212974
abnormal sleep pattern J:212974
fragmentation of sleep/wake states J:212974
increased frequency of paradoxical sleep J:212974
increased slow-wave sleep duration J:212974
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory