Htr1b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Htr1b
5-hydroxytryptamine (serotonin) receptor 1B
MGI:96274

20 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b⁺ C57BL/6N-Htr1b^{tm1.1(KOMP)Vlcg}/J	decreased grip strength	J:211773
	decreased total body fat amount	J:211773
	hyperactivity	J:211773
	increased heart weight	J:211773
	increased lean body mass	J:211773
Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b^{tm1.1(KOMP)Vlcg} C57BL/6N-Htr1b^{tm1.1(KOMP)Vlcg}/J	preweaning lethality, incomplete penetrance	J:211773
Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b^{tm1.1(KOMP)Vlcg} involves: C57BL/6NTac	normal endocrine/exocrine gland phenotype	J:284574
Htr1b^tm1Rhn/Htr1b⁺ involves: 129S2/SvPas	increased bone mass	J:146078
	increased bone ossification	J:146078
	increased osteoblast cell number	J:146078
Htr1b^tm1Rhn/Htr1b^tm1Rhn involves: 129S2/SvPas	abnormal locomotor activation	J:96221
	abnormal spatial learning	J:96221
	decreased anxiety-related response	J:96656
	decreased startle reflex	J:96460
	increased aggression towards male mice	J:20209
	increased body weight	J:96318, J:96460
	increased bone mass	J:146078
	increased bone ossification	J:146078
	increased fluid intake	J:96318
	increased osteoblast cell number	J:146078
	increased osteoblast proliferation	J:146078
	small testis	J:96318
Htr1b^tm1Rhn/Htr1b^tm1Rhn involves: 129S2/SvPas * 129S6/SvEvTac	abnormal operant conditioning behavior	J:96223

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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