About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
MGI:96281
77 phenotypes from 8 alleles in 13 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Htr2ctm1.1Eme/Y
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		abnormal pilomotor reflex J:163043
decreased body length J:163043
decreased body weight J:163043
decreased food intake J:163043
decreased grip strength J:163043
dehydration J:163043
hunched posture J:163043
hypotonia J:163043
impaired coordination J:163043
increased energy expenditure J:163043
increased food intake J:163043
lethality at weaning, incomplete penetrance J:163043
mottled coat J:163043
postnatal growth retardation J:163043
postnatal lethality, incomplete penetrance J:163043
Htr2ctm1.1Eme/Htr2c+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased body weight J:163043
decreased food intake J:163043
postnatal growth retardation J:163043
Htr2ctm1.1Eme/Htr2ctm1.1Eme
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased body weight J:163043
postnatal growth retardation J:163043
Htr2ctm1Arte/Y
involves: C57BL/6 		normal behavior/neurological phenotype J:228775
normal homeostasis/metabolism phenotype J:228775
impaired passive avoidance behavior J:228775
increased circulating corticosterone level J:228775
increased coping response J:228775
Htr2ctm1Jke/Y
B6.129-Htr2ctm1Jke 		decreased lean body mass J:147514
hyperactivity J:147514
impaired behavioral response to xenobiotic J:147514
increased circulating leptin level J:147514
increased percent body fat/body weight J:147514
increased susceptibility to diet-induced obesity J:147514
increased white adipose tissue amount J:147514
polyphagia J:147514
premature death J:147514
tonic-clonic seizures J:147514
Htr2ctm1Jke/Y
Tg(Pomc1-cre)16Lowl/0
B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl 		normal adipose tissue phenotype J:147514
normal behavior/neurological phenotype J:147514
normal growth/size/body region phenotype J:147514
normal homeostasis/metabolism phenotype J:147514
premature death J:147514
tonic-clonic seizures J:147514
Htr2ctm1Jul/Y
B6.129S-Htr2ctm1Jul 		abnormal response to new environment J:51567
abnormal response/metabolism to endogenous compounds J:50262
abnormal spatial learning J:51567
abnormal tumor necrosis factor level J:50262
hyperglycemia J:50262
impaired glucose tolerance J:50262
increased circulating insulin level J:50262
increased circulating leptin level J:50262
increased epididymal fat pad weight J:50262
increased renal fat pad weight J:50262
increased susceptibility to age related obesity J:50262
increased susceptibility to diet-induced obesity J:50262
increased white adipose tissue amount J:50262
insulin resistance J:50262
polyphagia J:50262
reduced long-term potentiation J:51567
Htr2ctm1Jul/Y
either: (involves: 129S2/SvPas * C57BL/6J * DBA/2) or (involves: 129S4/SvJae * C57BL/6J * DBA/2) 		normal behavior/neurological phenotype J:24339
impaired behavioral response to xenobiotic J:24339
increased body weight J:24339
increased epididymal fat pad weight J:24339
increased grooming behavior J:24339
increased renal fat pad weight J:24339
increased susceptibility to pharmacologically induced seizures J:24339
increased white adipose tissue amount J:24339
normal nervous system phenotype J:24339
polyphagia J:24339
premature death J:24339
sporadic seizures J:24339
tonic seizures J:24339
tonic-clonic seizures J:24339
Htr2ctm1Knk/Y
B6.Cg-Htr2ctm1Knk 		abnormal body temperature J:142503
abnormal metabolism J:142503
decreased body fat mass J:142503
decreased body length J:142503
decreased body mass index J:142503
decreased body weight J:142503
decreased brown adipose tissue mass J:142503
decreased circulating cholesterol level J:142503
decreased circulating glucose level J:142503
decreased circulating insulin level J:142503
decreased circulating insulin-like growth factor I level J:142503
decreased circulating leptin level J:142503
decreased circulating triglyceride level J:142503
decreased locomotor activity J:142503
decreased white adipose tissue amount J:142503
enhanced behavioral response to xenobiotic J:142503
normal homeostasis/metabolism phenotype J:142503
increased basal metabolism J:142503
increased circulating ghrelin level J:142503
increased circulating growth hormone level J:142503
increased physiological sensitivity to xenobiotic J:142503
increased susceptibility to xenobiotic induced morbidity/mortality J:142503
polyphagia J:142503
postnatal growth retardation J:142503
postnatal lethality, incomplete penetrance J:142503
slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2c+
B6.Cg-Htr2ctm1Knk 		slow postnatal weight gain J:142503
Htr2ctm1Knk/Y
C.Cg-Htr2ctm1Knk 		slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2ctm1Knk
B6.Cg-Htr2ctm1Knk 		decreased body length J:142503
decreased body mass index J:142503
decreased body weight J:142503
postnatal lethality, incomplete penetrance J:142503
slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2ctm1Knk
C.Cg-Htr2ctm1Knk 		slow postnatal weight gain J:142503
Htr2ctm1Knk/Htr2ctm2Knk
B6.Cg-Htr2ctm1Knk/Htr2ctm2Knk 		slow postnatal weight gain J:142503
Htr2ctm2Jke/Htr2ctm2Jke
Tg(Pomc1-cre)16Lowl/0
involves: 129X1/SvJ * C57BL/6J * FVB/N 		abnormal respiratory quotient J:207704
decreased oxygen consumption J:207704
normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
hyperactivity J:207704
hyperglycemia J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased energy expenditure J:207704
increased food intake J:207704
increased oxygen consumption J:207704
increased susceptibility to diet-induced obesity J:207704
insulin resistance J:207704
normal mortality/aging J:207704
Htr2ctm2Jke/Htr2ctm2Jke
Tg(Pomc-cre/ERT2)#Jke/0
involves: 129X1/SvJ * C57BL/6J 		normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased food intake J:207704
increased oxygen consumption J:207704
Htr2ctm2Jke/Y
Tg(Pomc1-cre)16Lowl/0
involves: 129X1/SvJ * C57BL/6J * FVB/N 		abnormal respiratory quotient J:207704
decreased oxygen consumption J:207704
normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
hyperactivity J:207704
hyperglycemia J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased energy expenditure J:207704
increased food intake J:207704
increased oxygen consumption J:207704
increased susceptibility to diet-induced obesity J:207704
insulin resistance J:207704
normal mortality/aging J:207704
Htr2ctm2Jke/Y
Tg(Pomc-cre/ERT2)#Jke/0
involves: 129X1/SvJ * C57BL/6J 		normal growth/size/body region phenotype J:207704
normal homeostasis/metabolism phenotype J:207704
increased body weight J:207704
increased circulating glucagon level J:207704
increased circulating glucose level J:207704
increased circulating insulin level J:207704
increased food intake J:207704
increased oxygen consumption J:207704
Htr2ctm2Jke/Y
Tg(Zp3-cre)93Knw/0
involves: 129X1/SvJ * C57BL/6J 		hyperglycemia J:207704
increased susceptibility to diet-induced obesity J:207704
premature death J:207704
seizures J:207704
Htr2ctm2Knk/Y
either: B6.Cg-Htr2ctm2Knk or C.Cg-Htr2ctm2Knk 		normal growth/size/body region phenotype J:142503
normal homeostasis/metabolism phenotype J:142503
Htr2ctm2Knk/Htr2ctm2Knk
either: B6.Cg-Htr2ctm2Knk or C.Cg-Htr2ctm2Knk 		normal growth/size/body region phenotype J:142503
normal homeostasis/metabolism phenotype J:142503
Htr2ctm2Lex/Htr2ctm2Lex
involves: 129S5/SvEvBrd * C57BL/6J 		normal adipose tissue phenotype J:185494
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory