Slc6a4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
MGI:96285

61 phenotypes from 6 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc6a4^{Gt1(IRESBetageo)lLex}/Slc6a4^{Gt1(IRESBetageo)lLex} involves: 129S5/SvEvBrd * C57BL/6J	abnormal response to novel object	J:108880
	behavioral despair	J:108880
	decreased exploration in new environment	J:108880
Slc6a4^tm1(cre)Xz/Slc6a4⁺ involves: 129S1/Sv * C57BL/6 * SJL	no abnormal phenotype detected	J:115426
Slc6a4^tm1(cre)Xz/Slc6a4^tm1(cre)Xz involves: 129S1/Sv * C57BL/6	cardiac fibrosis	J:155633
	postnatal lethality, incomplete penetrance	J:155633
Slc6a4^tm1.1Rbl/Slc6a4^tm1.1Rbl 129S6/SvEvTac-Slc6a4^tm1.1Rbl	abnormal neuron physiology	J:170356
	decreased physiological sensitivity to xenobiotic	J:170356
	impaired behavioral response to xenobiotic	J:170356
Slc6a4^tm1Grch/Slc6a4^tm1Grch involves: 129S6/SvEvTac * C57BL/6	abnormal action potential	J:109542
	abnormal active avoidance behavior	J:109542
	abnormal anxiety-related response	J:109542
	abnormal fear/anxiety-related behavior	J:109542
	abnormal response to new environment	J:109542
	abnormal serotonergic neuron morphology	J:109542
Slc6a4^tm1Kpl/Slc6a4⁺ B6.129-Slc6a4^tm1Kpl	abnormal social investigation	J:144937
	increased brain weight	J:144937
	megacephaly	J:144937
Slc6a4^tm1Kpl/Slc6a4⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal barrel cortex morphology	J:71182
	enhanced conditioned place preference behavior	J:48275
Slc6a4^tm1Kpl/Slc6a4⁺ involves: 129S1/Sv * 129X1/SvJ * CD-1	hyperactivity	J:76020
Slc6a4^tm1Kpl/Slc6a4^tm1Kpl B6.129-Slc6a4^tm1Kpl	abnormal response to novel object	J:108880
	behavioral despair	J:108880
	decreased exploration in new environment	J:108880
	social withdrawal	J:151144
Slc6a4^tm1Kpl/Slc6a4^tm1Kpl involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal digestive system physiology	J:237081
	abnormal enteric nervous system morphology	J:237081
	abnormal enteric neuron morphology	J:237081
	abnormal gastrointestinal motility	J:237081
	abnormal heart valve morphology	J:121505
	abnormal intestinal peristalsis	J:237081
	abnormal neurite morphology	J:237081
	abnormal small intestinal transit time	J:237081
	abnormal small intestinal villus morphology	J:237081
	abnormal small intestine crypts of Lieberkuhn morphology	J:237081
	cardiac fibrosis	J:121505
	decreased cardiac muscle contractility	J:121505
	decreased serotonin level	J:121505
	dilated cardiomyopathy	J:121505
	heart valve hyperplasia	J:121505
Slc6a4^tm1Kpl/Slc6a4^tm1Kpl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal brain morphology	J:89816
	abnormal heart ventricle morphology	J:62768
	abnormal pulmonary artery morphology	J:62768
	abnormal sleep pattern	J:89835
	abnormal thermal nociception	J:81734
	decreased serotonin level	J:62768
	enhanced conditioned place preference behavior	J:48275
	heart right ventricle hypertrophy	J:62768
	increased right ventricle systolic pressure	J:62768
Slc6a4^tm1Kpl/Slc6a4^tm1Kpl involves: 129S1/Sv * 129X1/SvJ * CD-1	abnormal body temperature homeostasis	J:59654
	decreased locomotor activity	J:76020
	decreased serotonin level	J:76020
Slc6a4^tm2.1Rbl/Slc6a4^tm2.1Rbl involves: 129S4/SvJae * 129S6/SvEvTac	abnormal crypts of Lieberkuhn morphology	J:237081
	abnormal digestive system physiology	J:237081
	abnormal enteric nervous system morphology	J:237081
	abnormal enteric neuron morphology	J:237081
	abnormal gastrointestinal motility	J:237081
	abnormal intestinal transit time	J:237081
	abnormal nervous system electrophysiology	J:202876
	abnormal neurotransmitter uptake	J:202876
	abnormal response to social novelty	J:202876
	abnormal small intestinal crypt cell proliferation	J:237081
	abnormal small intestine crypts of Lieberkuhn morphology	J:237081
	decreased small intestinal villus height	J:237081
	decreased vocalization	J:202876
	enhanced behavioral response to xenobiotic	J:202876
	increased physiological sensitivity to xenobiotic	J:202876
	increased serotonin level	J:202876
	increased startle reflex	J:202876
	increased stereotypic behavior	J:202876
	intestinal hypoperistalsis	J:237081
	social withdrawal	J:202876
Slc6a4^tm2.1Rbl/Slc6a4^tm2.1Rbl involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	normal growth/size/body region phenotype	J:202521
	normal mortality/aging	J:202521

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