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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Iapp
islet amyloid polypeptide
MGI:96382
25 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Iapptm1Sgm/Iapp+
involves: 129P2/OlaHsd 		abnormal trabecular bone morphology J:88964
decreased bone mass J:88964
decreased bone mineral density J:88964
decreased compact bone thickness J:88964
increased bone resorption J:88964
increased osteoclast cell number J:88964
Iapptm1Sgm/Iapptm1Sgm
involves: 129P2/OlaHsd 		abnormal trabecular bone morphology J:88964
decreased bone mineral density J:88964
decreased compact bone thickness J:88964
increased bone resorption J:88964
increased osteoclast cell number J:88964
osteoporosis J:88964
Iapptm1Sgm/Iapptm1Sgm
involves: 129P2/OlaHsd * C57BL/6 		normal homeostasis/metabolism phenotype J:50042
improved glucose tolerance J:50042
increased body weight J:50042
increased circulating insulin level J:50042
Tg(Ins2-Iapp)6Soel/Tg(Ins2-Iapp)6Soel
involves: FVB/N 		abnormal pancreatic islet morphology J:130022
decreased susceptibility to autoimmune diabetes J:130022
Tg(Ins2-IAPP)L13Gjsc/0
FVB/N-Tg(Ins2-IAPP)L13Gjsc 		abnormal homeostasis J:142009
abnormal pancreas physiology J:142009
abnormal pancreatic beta cell physiology J:142009
abnormal pancreatic islet morphology J:142009
decreased circulating insulin level J:142009
decreased insulin secretion J:142009
decreased pancreatic beta cell mass J:142009
decreased pancreatic beta cell number J:142009
hyperglycemia J:142009
impaired glucose tolerance J:142009
increased amylin secretion J:142009
increased circulating glucagon level J:142009
increased pancreatic beta cell apoptosis J:142009
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory